Evaluation of derivatives of 3-(2-oxo-1-pyrrolidine) hexahydro-1H-azepine-2-one as dermal penetration enhancers : side chain length variation and molecular modeling

The present study examined the enhancement effect of two series of compounds derived from 3-(2-oxo-1-pyrrolidine)hexahydro-1H-azepine-2-one. One series possessed alkyl side chains (series I) and the other alkyl ester side chains (series II). An in vitro diffusion study was performed to investigate t...

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Veröffentlicht in:	Journal of controlled release 2001-06, Vol.73 (2-3), p.183-196
Hauptverfasser:	KIM, N, EL-KATTAN, A. F, ASBILL, C. S, KENNETTE, R. J, SOWELL, J. W, LATOUR, R, MICHNIAK, B. B
Format:	Artikel
Sprache:	eng
Schlagworte:	3-(2-oxo-1-pyrrolidine) hexahydro-1H-azepine-2-one Animals Azepines - administration & dosage Biological and medical sciences General pharmacology Hydrocortisone - administration & dosage Hydrocortisone - pharmacokinetics Medical sciences Mice Mice, Hairless Models, Molecular Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Skin - metabolism Solubility Structure-Activity Relationship
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