The qualitative and quantitative determination of quinolones of first and second generation by capillary electrophoresis
Capillary electrophoresis (CE) was applied to the study of 10 quinolones of first and second generation — nalidixic acid, oxolinic acid, pipemidic acid, cinoxacin, norfloxacin, ciprofloxacin, ofloxacin, pefloxacin, fleroxacin, and flumequine. Separation was performed on a fused silica capillary (75...
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| Veröffentlicht in: | Journal of pharmaceutical and biomedical analysis 2000-06, Vol.22 (5), p.763-772 |
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| creator | Fierens, C Hillaert, S Van den Bossche, W |
| description | Capillary electrophoresis (CE) was applied to the study of 10 quinolones of first and second generation — nalidixic acid, oxolinic acid, pipemidic acid, cinoxacin, norfloxacin, ciprofloxacin, ofloxacin, pefloxacin, fleroxacin, and flumequine. Separation was performed on a fused silica capillary (75 μm–60 cm) using a phosphate buffer (pH 7.0, 125 mM). Detection was at 214 nm. Only norfloxacin and ciprofloxacin cannot be separated in this way. Because of the specificity of the method, the identification of the individual quinolones by their migration time was possible. The same system has been applied for the quantitative determination of quinolones in tablets and capsules. Excipients do not adversely affect the results. Some parameters (linearity, precision, accuracy) were validated. Especially the possibility of simultaneous quantification and identification of the active ingredient in the finished product is very attractive. |
| doi_str_mv | 10.1016/S0731-7085(99)00282-4 |
| format | Article |
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Separation was performed on a fused silica capillary (75 μm–60 cm) using a phosphate buffer (pH 7.0, 125 mM). Detection was at 214 nm. Only norfloxacin and ciprofloxacin cannot be separated in this way. Because of the specificity of the method, the identification of the individual quinolones by their migration time was possible. The same system has been applied for the quantitative determination of quinolones in tablets and capsules. Excipients do not adversely affect the results. Some parameters (linearity, precision, accuracy) were validated. 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Separation was performed on a fused silica capillary (75 μm–60 cm) using a phosphate buffer (pH 7.0, 125 mM). Detection was at 214 nm. Only norfloxacin and ciprofloxacin cannot be separated in this way. Because of the specificity of the method, the identification of the individual quinolones by their migration time was possible. The same system has been applied for the quantitative determination of quinolones in tablets and capsules. Excipients do not adversely affect the results. Some parameters (linearity, precision, accuracy) were validated. Especially the possibility of simultaneous quantification and identification of the active ingredient in the finished product is very attractive.</description><subject>Analysis</subject><subject>Biological and medical sciences</subject><subject>Capillary electrophoresis</subject><subject>Electrophoresis, Capillary - methods</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Qualitative analysis</subject><subject>Quantitative analysis</subject><subject>Quinolones</subject><subject>Quinolones - analysis</subject><subject>Reference Standards</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>0731-7085</issn><issn>1873-264X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpaDYfP6HFh1LSg5uRZUvWKZTQLwj0kARyE9rRuFHxShvJG5p_X-16-3GLLsNIz4xeHsZec_jAgcvza1CC1wr67kzr9wBN39TtC7bgvRJ1I9u7l2zxFzlkRzn_BICO6_YVO-TQ805xvWC_bu6petjY0U928o9U2eC2fZj-XDiaKK18KF0MVRzKqw9xjIHytht8ytNuKhPGUn5QoDTDy6cK7dqPo01PFY2EU4rr-5go-3zCDgY7Zjrd12N2-_nTzeXX-ur7l2-XH69qFBqmWgmFTna6l7YFAU3X9oLTEpbWASop5CCF6LhrrBVaDhwarqx0iI2yiALFMXs3712n-LChPJmVz0glU6C4yUbxcmQvCtjNIKaYc6LBrJNfleSGg9kqNzvlZuvTaG12yk1b5t7sP9gsV-T-m5odF-DtHrAZ7TgkG9Dnf5wQrZRQsIsZo2Lj0VMyGT0FJOdTMWdc9M8k-Q2nEqAB</recordid><startdate>20000601</startdate><enddate>20000601</enddate><creator>Fierens, C</creator><creator>Hillaert, S</creator><creator>Van den Bossche, W</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000601</creationdate><title>The qualitative and quantitative determination of quinolones of first and second generation by capillary electrophoresis</title><author>Fierens, C ; Hillaert, S ; Van den Bossche, W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-737cd65986a4030254831eb0bad0c7636f63351d2aa396f10217a6dcc27acc3c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analysis</topic><topic>Biological and medical sciences</topic><topic>Capillary electrophoresis</topic><topic>Electrophoresis, Capillary - methods</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Qualitative analysis</topic><topic>Quantitative analysis</topic><topic>Quinolones</topic><topic>Quinolones - analysis</topic><topic>Reference Standards</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fierens, C</creatorcontrib><creatorcontrib>Hillaert, S</creatorcontrib><creatorcontrib>Van den Bossche, W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fierens, C</au><au>Hillaert, S</au><au>Van den Bossche, W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The qualitative and quantitative determination of quinolones of first and second generation by capillary electrophoresis</atitle><jtitle>Journal of pharmaceutical and biomedical analysis</jtitle><addtitle>J Pharm Biomed Anal</addtitle><date>2000-06-01</date><risdate>2000</risdate><volume>22</volume><issue>5</issue><spage>763</spage><epage>772</epage><pages>763-772</pages><issn>0731-7085</issn><eissn>1873-264X</eissn><coden>JPBADA</coden><abstract>Capillary electrophoresis (CE) was applied to the study of 10 quinolones of first and second generation — nalidixic acid, oxolinic acid, pipemidic acid, cinoxacin, norfloxacin, ciprofloxacin, ofloxacin, pefloxacin, fleroxacin, and flumequine. 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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis Biological and medical sciences Capillary electrophoresis Electrophoresis, Capillary - methods General pharmacology Medical sciences Pharmacology. Drug treatments Qualitative analysis Quantitative analysis Quinolones Quinolones - analysis Reference Standards Reproducibility of Results Sensitivity and Specificity Spectrophotometry, Ultraviolet |
| title | The qualitative and quantitative determination of quinolones of first and second generation by capillary electrophoresis |
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