Correlation of Genetic Instability with Mismatch Repair Protein Expression and p53 Mutations in Non-Small Cell Lung Cancer

To examine the etiological association of genetic instability in lung tumorigenesis, we investigated the frequency of microsatellite instability (MI) of eight dinucleotide repeat markers in 68 patients with non-small cell lung cancer. Twenty-eight patients (41.2%) evidenced instability in multiple t...

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Veröffentlicht in:	Clinical cancer research 2000-05, Vol.6 (5), p.1639-1646
Hauptverfasser:	Chang, J W, Chen, Y C, Chen, C Y, Chen, J T, Chen, S K, Wang, Y C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adult Aged Aged, 80 and over Base Sequence Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Carrier Proteins DNA Mutational Analysis DNA, Neoplasm - chemistry DNA, Neoplasm - genetics Female Humans Immunohistochemistry Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Middle Aged Mutation MutL Protein Homolog 1 Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Nuclear Proteins Prognosis Sequence Deletion Survival Analysis Tumor Suppressor Protein p53 - genetics
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