Lack of association of the Ala45Thr variant in the BETA2/NEUROD1 with type 1 diabetes in Japanese
To evaluate the role of the Ala45Thr variant of BETA2/NEUROD1 in the development of type 1 or type 2 diabetes, we studied a Japanese population consisting of 383 control subjects, 234 type 1 diabetes patients and 160 type 2 diabetes patients. Both genotypewise and allelewise, there was no significan...
Gespeichert in:
| Veröffentlicht in: | Diabetes research and clinical practice 2000-07, Vol.49 (1), p.61-63 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 63 |
|---|---|
| container_issue | 1 |
| container_start_page | 61 |
| container_title | Diabetes research and clinical practice |
| container_volume | 49 |
| creator | Awata, Takuya Inoue, Kiyoaki Inoue, Ikuo Abe, Takahiro Takino, Hirofumi Kanazawa, Yasunori Katayama, Shigehiro |
| description | To evaluate the role of the Ala45Thr variant of BETA2/NEUROD1 in the development of type 1 or type 2 diabetes, we studied a Japanese population consisting of 383 control subjects, 234 type 1 diabetes patients and 160 type 2 diabetes patients. Both genotypewise and allelewise, there was no significant association of the variant with type 1 diabetes or type 2 diabetes in Japanese. Also, there were no significant differences in clinical characteristics with and without the variant. Our present results do not support a recent report which described an association of the Ala45Thr variant with type 1 diabetes in Japanese. |
| doi_str_mv | 10.1016/S0168-8227(00)00118-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71111395</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0168822700001182</els_id><sourcerecordid>71111395</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-17528c7ef81a719e853c301ef95d131d848947afd06bacca5ff7f93499d96c4d3</originalsourceid><addsrcrecordid>eNqFkEtvEzEQgC0EoqHwE0A-oAoO23rW-7BPKG0DFEVUgvRsTbxjxbDZDbbTqv8e5yHgxlgay6NvxqOPsdcgzkFAc_E9J1WosmzfCfFeCABVlE_YBFRb7stP2eQPcsJexPhDCNHIqn7OTkCofJpqwnCO9icfHccYR-sx-XHYPdOK-LTHql6sAr_H4HFI3A_7-uVsMS0vvs7uvt1eA3_wacXT44Y48M7jkhLFHfkFNzhQpJfsmcM-0qvjfcruPs4WV5-L-e2nm6vpvLBSi1RAW5fKtuQUYAuaVC2tFEBO1x1I6FSldNWi60SzRGuxdq51WlZad7qxVSdP2dlh7iaMv7YUk1n7aKnv8xbjNpoWckhdZ7A-gDaMMQZyZhP8GsOjAWF2bs3erdmJM0KYvVtT5r43xw-2yzV1_3QdZGbg7RHAaLF3AQfr41-uAlmDytiHA0bZxr2nYKL1NFjqfCCbTDf6_2zyG07akuU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71111395</pqid></control><display><type>article</type><title>Lack of association of the Ala45Thr variant in the BETA2/NEUROD1 with type 1 diabetes in Japanese</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Awata, Takuya ; Inoue, Kiyoaki ; Inoue, Ikuo ; Abe, Takahiro ; Takino, Hirofumi ; Kanazawa, Yasunori ; Katayama, Shigehiro</creator><creatorcontrib>Awata, Takuya ; Inoue, Kiyoaki ; Inoue, Ikuo ; Abe, Takahiro ; Takino, Hirofumi ; Kanazawa, Yasunori ; Katayama, Shigehiro</creatorcontrib><description>To evaluate the role of the Ala45Thr variant of BETA2/NEUROD1 in the development of type 1 or type 2 diabetes, we studied a Japanese population consisting of 383 control subjects, 234 type 1 diabetes patients and 160 type 2 diabetes patients. Both genotypewise and allelewise, there was no significant association of the variant with type 1 diabetes or type 2 diabetes in Japanese. Also, there were no significant differences in clinical characteristics with and without the variant. Our present results do not support a recent report which described an association of the Ala45Thr variant with type 1 diabetes in Japanese.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/S0168-8227(00)00118-2</identifier><identifier>PMID: 10808064</identifier><identifier>CODEN: DRCPE9</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Alleles ; Basic Helix-Loop-Helix Transcription Factors ; BETA2/NEUROD1 ; Biological and medical sciences ; Diabetes Mellitus, Type 1 - genetics ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; DNA - chemistry ; DNA Primers - chemistry ; DNA-Binding Proteins - chemistry ; DNA-Binding Proteins - genetics ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Genotype ; Helix-Loop-Helix Motifs ; Humans ; Japan ; Japanese ; Male ; Medical sciences ; Middle Aged ; Mutation ; Polymerase Chain Reaction ; Trans-Activators - chemistry ; Trans-Activators - genetics ; Transcription Factors - genetics ; Type 1 diabetes</subject><ispartof>Diabetes research and clinical practice, 2000-07, Vol.49 (1), p.61-63</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-17528c7ef81a719e853c301ef95d131d848947afd06bacca5ff7f93499d96c4d3</citedby><cites>FETCH-LOGICAL-c390t-17528c7ef81a719e853c301ef95d131d848947afd06bacca5ff7f93499d96c4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0168-8227(00)00118-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1413518$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10808064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Awata, Takuya</creatorcontrib><creatorcontrib>Inoue, Kiyoaki</creatorcontrib><creatorcontrib>Inoue, Ikuo</creatorcontrib><creatorcontrib>Abe, Takahiro</creatorcontrib><creatorcontrib>Takino, Hirofumi</creatorcontrib><creatorcontrib>Kanazawa, Yasunori</creatorcontrib><creatorcontrib>Katayama, Shigehiro</creatorcontrib><title>Lack of association of the Ala45Thr variant in the BETA2/NEUROD1 with type 1 diabetes in Japanese</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>To evaluate the role of the Ala45Thr variant of BETA2/NEUROD1 in the development of type 1 or type 2 diabetes, we studied a Japanese population consisting of 383 control subjects, 234 type 1 diabetes patients and 160 type 2 diabetes patients. Both genotypewise and allelewise, there was no significant association of the variant with type 1 diabetes or type 2 diabetes in Japanese. Also, there were no significant differences in clinical characteristics with and without the variant. Our present results do not support a recent report which described an association of the Ala45Thr variant with type 1 diabetes in Japanese.</description><subject>Adult</subject><subject>Alleles</subject><subject>Basic Helix-Loop-Helix Transcription Factors</subject><subject>BETA2/NEUROD1</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 1 - genetics</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>DNA - chemistry</subject><subject>DNA Primers - chemistry</subject><subject>DNA-Binding Proteins - chemistry</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Genotype</subject><subject>Helix-Loop-Helix Motifs</subject><subject>Humans</subject><subject>Japan</subject><subject>Japanese</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Polymerase Chain Reaction</subject><subject>Trans-Activators - chemistry</subject><subject>Trans-Activators - genetics</subject><subject>Transcription Factors - genetics</subject><subject>Type 1 diabetes</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtvEzEQgC0EoqHwE0A-oAoO23rW-7BPKG0DFEVUgvRsTbxjxbDZDbbTqv8e5yHgxlgay6NvxqOPsdcgzkFAc_E9J1WosmzfCfFeCABVlE_YBFRb7stP2eQPcsJexPhDCNHIqn7OTkCofJpqwnCO9icfHccYR-sx-XHYPdOK-LTHql6sAr_H4HFI3A_7-uVsMS0vvs7uvt1eA3_wacXT44Y48M7jkhLFHfkFNzhQpJfsmcM-0qvjfcruPs4WV5-L-e2nm6vpvLBSi1RAW5fKtuQUYAuaVC2tFEBO1x1I6FSldNWi60SzRGuxdq51WlZad7qxVSdP2dlh7iaMv7YUk1n7aKnv8xbjNpoWckhdZ7A-gDaMMQZyZhP8GsOjAWF2bs3erdmJM0KYvVtT5r43xw-2yzV1_3QdZGbg7RHAaLF3AQfr41-uAlmDytiHA0bZxr2nYKL1NFjqfCCbTDf6_2zyG07akuU</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>Awata, Takuya</creator><creator>Inoue, Kiyoaki</creator><creator>Inoue, Ikuo</creator><creator>Abe, Takahiro</creator><creator>Takino, Hirofumi</creator><creator>Kanazawa, Yasunori</creator><creator>Katayama, Shigehiro</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000701</creationdate><title>Lack of association of the Ala45Thr variant in the BETA2/NEUROD1 with type 1 diabetes in Japanese</title><author>Awata, Takuya ; Inoue, Kiyoaki ; Inoue, Ikuo ; Abe, Takahiro ; Takino, Hirofumi ; Kanazawa, Yasunori ; Katayama, Shigehiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-17528c7ef81a719e853c301ef95d131d848947afd06bacca5ff7f93499d96c4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Basic Helix-Loop-Helix Transcription Factors</topic><topic>BETA2/NEUROD1</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Type 1 - genetics</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>DNA - chemistry</topic><topic>DNA Primers - chemistry</topic><topic>DNA-Binding Proteins - chemistry</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Genotype</topic><topic>Helix-Loop-Helix Motifs</topic><topic>Humans</topic><topic>Japan</topic><topic>Japanese</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Polymerase Chain Reaction</topic><topic>Trans-Activators - chemistry</topic><topic>Trans-Activators - genetics</topic><topic>Transcription Factors - genetics</topic><topic>Type 1 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Awata, Takuya</creatorcontrib><creatorcontrib>Inoue, Kiyoaki</creatorcontrib><creatorcontrib>Inoue, Ikuo</creatorcontrib><creatorcontrib>Abe, Takahiro</creatorcontrib><creatorcontrib>Takino, Hirofumi</creatorcontrib><creatorcontrib>Kanazawa, Yasunori</creatorcontrib><creatorcontrib>Katayama, Shigehiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Awata, Takuya</au><au>Inoue, Kiyoaki</au><au>Inoue, Ikuo</au><au>Abe, Takahiro</au><au>Takino, Hirofumi</au><au>Kanazawa, Yasunori</au><au>Katayama, Shigehiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of association of the Ala45Thr variant in the BETA2/NEUROD1 with type 1 diabetes in Japanese</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>49</volume><issue>1</issue><spage>61</spage><epage>63</epage><pages>61-63</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><coden>DRCPE9</coden><abstract>To evaluate the role of the Ala45Thr variant of BETA2/NEUROD1 in the development of type 1 or type 2 diabetes, we studied a Japanese population consisting of 383 control subjects, 234 type 1 diabetes patients and 160 type 2 diabetes patients. Both genotypewise and allelewise, there was no significant association of the variant with type 1 diabetes or type 2 diabetes in Japanese. Also, there were no significant differences in clinical characteristics with and without the variant. Our present results do not support a recent report which described an association of the Ala45Thr variant with type 1 diabetes in Japanese.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>10808064</pmid><doi>10.1016/S0168-8227(00)00118-2</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0168-8227 |
| ispartof | Diabetes research and clinical practice, 2000-07, Vol.49 (1), p.61-63 |
| issn | 0168-8227 1872-8227 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71111395 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Alleles Basic Helix-Loop-Helix Transcription Factors BETA2/NEUROD1 Biological and medical sciences Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance DNA - chemistry DNA Primers - chemistry DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Genotype Helix-Loop-Helix Motifs Humans Japan Japanese Male Medical sciences Middle Aged Mutation Polymerase Chain Reaction Trans-Activators - chemistry Trans-Activators - genetics Transcription Factors - genetics Type 1 diabetes |
| title | Lack of association of the Ala45Thr variant in the BETA2/NEUROD1 with type 1 diabetes in Japanese |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T06%3A41%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lack%20of%20association%20of%20the%20Ala45Thr%20variant%20in%20the%20BETA2/NEUROD1%20with%20type%201%20diabetes%20in%20Japanese&rft.jtitle=Diabetes%20research%20and%20clinical%20practice&rft.au=Awata,%20Takuya&rft.date=2000-07-01&rft.volume=49&rft.issue=1&rft.spage=61&rft.epage=63&rft.pages=61-63&rft.issn=0168-8227&rft.eissn=1872-8227&rft.coden=DRCPE9&rft_id=info:doi/10.1016/S0168-8227(00)00118-2&rft_dat=%3Cproquest_cross%3E71111395%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71111395&rft_id=info:pmid/10808064&rft_els_id=S0168822700001182&rfr_iscdi=true |