Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production

Three novel alternatively spliced transcripts of the beta-site amyloid precursor protein cleaving enzyme (BACE) were cloned from human brain. Alternative splicing of the RNA occurs at an internal donor in exon 3 and/or an internal acceptor in exon 4. The splicing events lead to a deletion of 25 (BAC...

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Veröffentlicht in:	Neuroscience letters 2001-07, Vol.307 (1), p.9-12
Hauptverfasser:	Tanahashi, Hiroshi, Tabira, Takeshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Alternative Splicing - genetics Alzheimer Disease - enzymology Alzheimer Disease - physiopathology Alzheimer's disease Amyloid beta Amyloid beta-Peptides - biosynthesis Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases - genetics Aspartic Acid Endopeptidases - metabolism Aspartic protease b-Site APP cleaving enzyme BACE protein Beta-site amyloid precursor protein cleaving enzyme Biochemistry and metabolism Biological and medical sciences Cells, Cultured - metabolism Central nervous system Cloning, Molecular Endoglycosidase H Endopeptidases Frontal Lobe - enzymology Frontal Lobe - physiopathology Fundamental and applied biological sciences. Psychology Genetic Vectors Glycosylation Humans Protease Protein Isoforms - genetics Protein Structure, Tertiary - genetics Transfection Vertebrates: nervous system and sense organs
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