Protection of outer hair cells from reperfusion injury by an iron chelator and a nitric oxide synthase inhibitor in the guinea pig cochlea

To examine whether an active process of the cochlea was injured by ischemia-reperfusion, time courses of distortion-product otoacoustic emissions (DPOAEs) were examined before, during and after 30 min cochlear ischemia using albino guinea pigs. DPOAEs decreased to the minimum level when the animals...

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Veröffentlicht in:	Neuroscience letters 2001-07, Vol.307 (1), p.29-32
Hauptverfasser:	Tabuchi, Keiji, Okubo, Hideki, Fujihira, Kazuya, Tsuji, Shigeki, Hara, Akira, Kusakari, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Active process Animals Biological and medical sciences Cochlea Deferoxamine - pharmacology Distortion-product otoacoustic emissions Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Enzyme Inhibitors - pharmacology Free radical Free Radicals - metabolism Fundamental and applied biological sciences. Psychology Guinea Pigs Hair Cells, Auditory, Outer - drug effects Hair Cells, Auditory, Outer - enzymology Hair Cells, Auditory, Outer - physiopathology Hearing - drug effects Hearing - physiology Iron Chelating Agents - pharmacology Ischemia Membrane Potentials - drug effects Membrane Potentials - physiology Neuroprotective Agents - pharmacology NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Reperfusion Injury - drug therapy Reperfusion Injury - enzymology Reperfusion Injury - physiopathology Vertebrates: nervous system and sense organs
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