Gabapentin affects glutamatergic excitatory neurotransmission in the rat dorsal horn

We investigated the effects of gabapentin (GBP) on glutamatergic synaptic transmission in the dorsal horn of the rat spinal cord. Patch clamp whole cell recordings were made from superficial and deep dorsal horn neurons of rat spinal cord slices. In the majority of neurons in the superficial lamina,...

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Veröffentlicht in:	Pain (Amsterdam) 2000-04, Vol.85 (3), p.405-414
Hauptverfasser:	Shimoyama, Megumi, Shimoyama, Naohito, Hori, Yuuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - pharmacology Amines Analgesics Animals Biological and medical sciences Cyclohexanecarboxylic Acids Dorsal horn neuron Excitatory Amino Acid Antagonists - pharmacology Excitatory Amino Acids - physiology Excitatory Postsynaptic Potentials - drug effects Gabapentin gamma-Aminobutyric Acid Glutamatergic neurotransmission Glutamic Acid - physiology In Vitro Techniques Medical sciences Neurons, Afferent - drug effects Neuropharmacology Neurotransmitter Agents - physiology Nociceptors - drug effects Patch-Clamp Techniques Pharmacology. Drug treatments Posterior Horn Cells - drug effects Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - drug effects Receptors, Presynaptic - drug effects Synaptic transmission Synaptic Transmission - drug effects
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