Tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in androgen-independent prostate cancer cells

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to induce cell death in a variety of transformed cells but spared the normal cells. In this study, we examined its potential against advanced prostate cancer cells. Treatment of PC-3 and DU145 cells with TRAIL caused a...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-05, Vol.60 (9), p.2384-2389
Hauptverfasser:	RONG YU, MANDLEKAR, S, RUBEN, S, JIAN NI, KONG, A.-N. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis Regulatory Proteins Biological and medical sciences Caspases - metabolism Cell Nucleus - metabolism Dose-Response Relationship, Drug Humans Male Medical sciences Membrane Glycoproteins - metabolism Membrane Glycoproteins - pharmacology Mitogen-Activated Protein Kinase 8 Mitogen-Activated Protein Kinases - metabolism Nephrology. Urinary tract diseases NF-kappa B - metabolism Prostatic Neoplasms - pathology Receptors, TNF-Related Apoptosis-Inducing Ligand Receptors, Tumor Necrosis Factor - metabolism Reverse Transcriptase Polymerase Chain Reaction Time Factors TNF-Related Apoptosis-Inducing Ligand Tumor Cells, Cultured Tumor Necrosis Factor-alpha - metabolism Tumor Necrosis Factor-alpha - pharmacology Tumors of the urinary system Urinary tract. Prostate gland
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