Vitronectin and Fibronectin Function as Glucan Binding Proteins Augmenting Macrophage Responses to Pneumocystis carinii

beta-glucans represent major structural components of fungal cell walls. We recently reported that Pneumocystis carinii beta-glucans stimulate alveolar macrophages to release proinflammatory cytokines. Macrophage activation by beta-glucan is augmented by serum, implying the presence of circulating f...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2001-08, Vol.25 (2), p.203-211
Hauptverfasser:	Vassallo, Robert, Kottom, Theodore J, Standing, Joseph E, Limper, Andrew H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - metabolism Cell Line Cell Wall - immunology DNA Primers - genetics Fibronectins - genetics Fibronectins - metabolism Glucans - metabolism Interleukin-6 - metabolism Lectins Liver - metabolism Lung - metabolism Macrophage Activation Macrophages, Alveolar - immunology Macrophages, Alveolar - microbiology Mice Pneumocystis - pathogenicity Pneumonia, Pneumocystis - genetics Pneumonia, Pneumocystis - immunology Pneumonia, Pneumocystis - metabolism Protein Binding Rats RNA, Messenger - genetics RNA, Messenger - metabolism Saccharomyces cerevisiae - immunology Tumor Necrosis Factor-alpha - biosynthesis Vitronectin - genetics Vitronectin - metabolism
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