Ligand responsiveness in human prostate cancer : Structural analysis of mutant androgen receptors from LNCaP and CWR22 tumors

Androgen receptors (ARs) belong to the family of hormone receptors that are ligand-dependent transcription factors. Endocrine therapy provides effective treatment for prostate cancer until mutations arise that alter the ligand responsiveness of AR. In this study, structural models were developed for...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-05, Vol.60 (9), p.2317-2322
Hauptverfasser:	MCDONALD, S, BRIVE, L, AGUS, D. B, SCHER, H. I, ELY, K. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Biological and medical sciences Humans Ligands Male Medical sciences Models, Molecular Molecular Sequence Data Mutation Neoplasms, Hormone-Dependent - genetics Neoplasms, Hormone-Dependent - metabolism Nephrology. Urinary tract diseases Prostatic Neoplasms - chemistry Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Receptors, Androgen - chemistry Receptors, Androgen - genetics Receptors, Androgen - metabolism Receptors, Progesterone - chemistry Receptors, Progesterone - metabolism Sequence Homology, Amino Acid Tumor Cells, Cultured Tumors of the urinary system Urinary tract. Prostate gland
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