Behavioral and biochemical effects of l-tryptophan and buspirone in a model of cerebellar atrophy

The Lurcher mutant mouse can be considered an adequate model of autosomal dominant spinocerebellar atrophy because of the severe degeneration of its cerebellar cortex and inferior olive. The purpose of this study was to determine whether the motor coordination deficits of Lurcher mutants could be im...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2001-07, Vol.69 (3), p.333-342
Hauptverfasser:	Le Marec, N, Ase, A.R, Botez-Marquard, T, Marchand, L, Reader, T.A, Lalonde, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ataxia Behavior, Animal - drug effects Behavior, Animal - physiology Behavioural testing Biological and medical sciences Brain - metabolism buspirone Buspirone - pharmacology Cerebellum Disease Models, Animal Female HPLC Hydroxyindoleacetic Acid - metabolism Lurcher mutant mice Medical sciences Mice Mice, Inbred CBA Mice, Neurologic Mutants Motor Skills - drug effects Motor Skills - physiology Myoclonic Cerebellar Dyssynergia - metabolism Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Serotonin Serotonin - metabolism Serotonin Receptor Agonists - pharmacology Serotoninergic system spinocerebellar atrophy Tryptophan - metabolism Tryptophan - pharmacology
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