Hypothesis: naked plasmid DNA is taken up by cells in vivo by a receptor-mediated process

Following the initial demonstration that intramuscularly‐injected naked plasmid DNA (pDNA) is expressed in myofibers, it was shown that pDNA can be used for vaccination purposes. More recent studies have indicated that naked pDNA can also achieve high levels of transgene expression in vivo. This eff...

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Veröffentlicht in:	The journal of gene medicine 2000-03, Vol.2 (2), p.76-88
Hauptverfasser:	Budker, Vladimir, Budker, Tatayana, Zhang, Guofeng, Subbotin, Vladimir, Loomis, Aaron, Wolff, Jon A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Endocytosis Gene therapy gene transfer Gene Transfer Techniques Injections, Intravenous liver Liver - cytology Liver - metabolism muscle plasma membrane receptor Plasmids - administration & dosage Plasmids - metabolism Polymers - pharmacology Receptors, Cell Surface - physiology
Online-Zugang:	Volltext
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