Cytotoxic Sesquiterpene Lactones Mediate their Death-Inducing Effect in Leukemia T Cells by Triggering Apoptosis
Abstract Cytotoxicity is a well characterized property of sesquiterpene lactones. In the present study, the question was addressed whether sesquiterpene lactones mediate their cytotoxic effect by triggering apoptosis. Four compounds, ambrosin, alantolactone, hymenin and helenalin were shown to induc...
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| Veröffentlicht in: | Planta medica 2001-08, Vol.67 (6), p.557-559 |
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| container_end_page | 559 |
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| container_issue | 6 |
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| container_title | Planta medica |
| container_volume | 67 |
| creator | Dirsch, Verena M. Stuppner, Hermann Vollmar, Angelika M. |
| description | Abstract
Cytotoxicity is a well characterized property of sesquiterpene lactones. In the present study, the question was addressed whether sesquiterpene lactones mediate their cytotoxic effect by triggering apoptosis. Four compounds, ambrosin, alantolactone, hymenin and helenalin were shown to induce apoptosis in Jurkat leukemia T cells as judged by cell morphology, the appearance of apoptotic nuclei as well as the translocation of phosphatidylserine to the outer surface of the cell membrane. |
| doi_str_mv | 10.1055/s-2001-16478 |
| format | Article |
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Cytotoxicity is a well characterized property of sesquiterpene lactones. In the present study, the question was addressed whether sesquiterpene lactones mediate their cytotoxic effect by triggering apoptosis. Four compounds, ambrosin, alantolactone, hymenin and helenalin were shown to induce apoptosis in Jurkat leukemia T cells as judged by cell morphology, the appearance of apoptotic nuclei as well as the translocation of phosphatidylserine to the outer surface of the cell membrane.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2001-16478</identifier><identifier>PMID: 11509981</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - pharmacology ; Apoptosis - drug effects ; Asteraceae - chemistry ; Biological and medical sciences ; Cell Survival ; Dose-Response Relationship, Drug ; Flow Cytometry ; General pharmacology ; Humans ; Jurkat Cells ; Lactones - chemistry ; Lactones - pharmacology ; Letter ; Medical sciences ; Necrosis ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Sesquiterpenes - chemistry ; Sesquiterpenes - pharmacology ; T-Lymphocytes - drug effects</subject><ispartof>Planta medica, 2001-08, Vol.67 (6), p.557-559</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-f34b613529e80cd32dbda6bc843959cd58ca5abdee7d8bf0d9e6d347a197d0733</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-16478.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2001-16478$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,778,782,3006,3007,27907,27908,54542,54543</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1109900$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11509981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dirsch, Verena M.</creatorcontrib><creatorcontrib>Stuppner, Hermann</creatorcontrib><creatorcontrib>Vollmar, Angelika M.</creatorcontrib><title>Cytotoxic Sesquiterpene Lactones Mediate their Death-Inducing Effect in Leukemia T Cells by Triggering Apoptosis</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
Cytotoxicity is a well characterized property of sesquiterpene lactones. In the present study, the question was addressed whether sesquiterpene lactones mediate their cytotoxic effect by triggering apoptosis. Four compounds, ambrosin, alantolactone, hymenin and helenalin were shown to induce apoptosis in Jurkat leukemia T cells as judged by cell morphology, the appearance of apoptotic nuclei as well as the translocation of phosphatidylserine to the outer surface of the cell membrane.</description><subject>Antineoplastic Agents, Phytogenic - chemistry</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Asteraceae - chemistry</subject><subject>Biological and medical sciences</subject><subject>Cell Survival</subject><subject>Dose-Response Relationship, Drug</subject><subject>Flow Cytometry</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Jurkat Cells</subject><subject>Lactones - chemistry</subject><subject>Lactones - pharmacology</subject><subject>Letter</subject><subject>Medical sciences</subject><subject>Necrosis</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Sesquiterpenes - chemistry</subject><subject>Sesquiterpenes - pharmacology</subject><subject>T-Lymphocytes - drug effects</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0UFv2yAUwHFUbWrSdLedKw5TL5s7MHZsjlWarpUy9bDsjDA8J7SxcXlYWr79SBNpO_QEh58e8IeQz5zdcFaW3zHLGeMZnxdVfUamvBAyY3nOP5ApYyLPmCzEhFwgPidWSMbOyYTzkklZ8ykZFvvoo__jDP0F-Dq6CGGAHuhKm-h7QPoTrNMRaNyCC_QOdNxmj70djes3dNm2YCJ1PV3B-AKd03RNF7DbIW32dB3cZgPhAG8HP0SPDi_Jx1bvED6d1hn5fb9cLx6y1dOPx8XtKjOizGPWiqKZ87SVUDNjRW4bq-eNqdPzSmlsWRtd6sYCVLZuWmYlzK0oKs1lZVklxIxcH-cOwb-OgFF1Dk26me7Bj6gqzllRiTrBb0dogkcM0KohuE6HveJMHQorVIfC6q1w4lenuWPTgf2HT0kT-HICGo3etUH3xuF_LrH0MTPy9cji1kEH6tmPoU9B3j_1L75YkeM</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>Dirsch, Verena M.</creator><creator>Stuppner, Hermann</creator><creator>Vollmar, Angelika M.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Cytotoxic Sesquiterpene Lactones Mediate their Death-Inducing Effect in Leukemia T Cells by Triggering Apoptosis</title><author>Dirsch, Verena M. ; Stuppner, Hermann ; Vollmar, Angelika M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-f34b613529e80cd32dbda6bc843959cd58ca5abdee7d8bf0d9e6d347a197d0733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antineoplastic Agents, Phytogenic - chemistry</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Asteraceae - chemistry</topic><topic>Biological and medical sciences</topic><topic>Cell Survival</topic><topic>Dose-Response Relationship, Drug</topic><topic>Flow Cytometry</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Jurkat Cells</topic><topic>Lactones - chemistry</topic><topic>Lactones - pharmacology</topic><topic>Letter</topic><topic>Medical sciences</topic><topic>Necrosis</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Sesquiterpenes - chemistry</topic><topic>Sesquiterpenes - pharmacology</topic><topic>T-Lymphocytes - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dirsch, Verena M.</creatorcontrib><creatorcontrib>Stuppner, Hermann</creatorcontrib><creatorcontrib>Vollmar, Angelika M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dirsch, Verena M.</au><au>Stuppner, Hermann</au><au>Vollmar, Angelika M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytotoxic Sesquiterpene Lactones Mediate their Death-Inducing Effect in Leukemia T Cells by Triggering Apoptosis</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>67</volume><issue>6</issue><spage>557</spage><epage>559</epage><pages>557-559</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
Cytotoxicity is a well characterized property of sesquiterpene lactones. In the present study, the question was addressed whether sesquiterpene lactones mediate their cytotoxic effect by triggering apoptosis. Four compounds, ambrosin, alantolactone, hymenin and helenalin were shown to induce apoptosis in Jurkat leukemia T cells as judged by cell morphology, the appearance of apoptotic nuclei as well as the translocation of phosphatidylserine to the outer surface of the cell membrane.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>11509981</pmid><doi>10.1055/s-2001-16478</doi><tpages>3</tpages></addata></record> |
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| ispartof | Planta medica, 2001-08, Vol.67 (6), p.557-559 |
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| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Asteraceae - chemistry Biological and medical sciences Cell Survival Dose-Response Relationship, Drug Flow Cytometry General pharmacology Humans Jurkat Cells Lactones - chemistry Lactones - pharmacology Letter Medical sciences Necrosis Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Sesquiterpenes - chemistry Sesquiterpenes - pharmacology T-Lymphocytes - drug effects |
| title | Cytotoxic Sesquiterpene Lactones Mediate their Death-Inducing Effect in Leukemia T Cells by Triggering Apoptosis |
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