A polymeric system for the intra-oral delivery of an anti-fungal agent
Oral candidal infections are often persistent and intractable and thus the aim of this study was to develop a polymeric sustained release device to improve the topical treatment of these infections. A self curing system based on poly(ethyl methacrylate) and tetrahydrofurfuryl methacrylate (PEM/THFM)...
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| Veröffentlicht in: | Biomaterials 2001-09, Vol.22 (17), p.2319-2324 |
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| container_title | Biomaterials |
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| creator | Patel, M.P Cruchley, A.T Coleman, D.C Swai, H Braden, M Williams, D.M |
| description | Oral candidal infections are often persistent and intractable and thus the aim of this study was to develop a polymeric sustained release device to improve the topical treatment of these infections. A self curing system based on poly(ethyl methacrylate) and tetrahydrofurfuryl methacrylate (PEM/THFM) was used with chlorhexidine diacetate (CX) added at levels between 0 and 12% w/w. Water uptake by the device was assessed gravimetrically and CX release measured by UV spectrometry. Anti candidal activity was established by culturing azole sensitive and resistant strains of
Candida albicans in the presence of the polymeric delivery device with and without CX. Candidal growth was measured by turbidimetry or surviving colony-forming unit (CFU) formation. There was an initial high release of CX over 24
h followed by a slow diffusion up to 7 days. CX inhibited candidal growth and survival markedly in vitro
, with the test samples showing less than 0.5×10
−7
CFU/ml compared to controls (3–4×10
−7
CFU/ml). These results indicate the potential of a chlorhexidine containing PEM/THFM polymeric system in the treatment of persistent candidal infections. |
| doi_str_mv | 10.1016/S0142-9612(00)00367-7 |
| format | Article |
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Candida albicans in the presence of the polymeric delivery device with and without CX. Candidal growth was measured by turbidimetry or surviving colony-forming unit (CFU) formation. There was an initial high release of CX over 24
h followed by a slow diffusion up to 7 days. CX inhibited candidal growth and survival markedly in vitro
, with the test samples showing less than 0.5×10
−7
CFU/ml compared to controls (3–4×10
−7
CFU/ml). These results indicate the potential of a chlorhexidine containing PEM/THFM polymeric system in the treatment of persistent candidal infections.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/S0142-9612(00)00367-7</identifier><identifier>PMID: 11511028</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Oral ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - administration & dosage ; Biocompatible Materials ; Biological and medical sciences ; Candida ; Candida albicans - drug effects ; Candida albicans - growth & development ; Chlorhexidine ; Chlorhexidine - administration & dosage ; Drug Delivery Systems ; Drug Resistance, Fungal ; Humans ; In Vitro Techniques ; Intra-oral ; Materials Testing ; Medical sciences ; Methacrylates ; Methylmethacrylates ; PEM/THFM ; Pharmacology. Drug treatments ; Polymeric delivery system ; Polymers</subject><ispartof>Biomaterials, 2001-09, Vol.22 (17), p.2319-2324</ispartof><rights>2001 Elsevier Science Ltd</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-f7a32b049445ee75cda91549f369fb2728c4dc8d8926d4b131f8741ec6c5c25c3</citedby><cites>FETCH-LOGICAL-c487t-f7a32b049445ee75cda91549f369fb2728c4dc8d8926d4b131f8741ec6c5c25c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961200003677$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1119249$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11511028$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, M.P</creatorcontrib><creatorcontrib>Cruchley, A.T</creatorcontrib><creatorcontrib>Coleman, D.C</creatorcontrib><creatorcontrib>Swai, H</creatorcontrib><creatorcontrib>Braden, M</creatorcontrib><creatorcontrib>Williams, D.M</creatorcontrib><title>A polymeric system for the intra-oral delivery of an anti-fungal agent</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Oral candidal infections are often persistent and intractable and thus the aim of this study was to develop a polymeric sustained release device to improve the topical treatment of these infections. A self curing system based on poly(ethyl methacrylate) and tetrahydrofurfuryl methacrylate (PEM/THFM) was used with chlorhexidine diacetate (CX) added at levels between 0 and 12% w/w. Water uptake by the device was assessed gravimetrically and CX release measured by UV spectrometry. Anti candidal activity was established by culturing azole sensitive and resistant strains of
Candida albicans in the presence of the polymeric delivery device with and without CX. Candidal growth was measured by turbidimetry or surviving colony-forming unit (CFU) formation. There was an initial high release of CX over 24
h followed by a slow diffusion up to 7 days. CX inhibited candidal growth and survival markedly in vitro
, with the test samples showing less than 0.5×10
−7
CFU/ml compared to controls (3–4×10
−7
CFU/ml). These results indicate the potential of a chlorhexidine containing PEM/THFM polymeric system in the treatment of persistent candidal infections.</description><subject>Administration, Oral</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Biocompatible Materials</subject><subject>Biological and medical sciences</subject><subject>Candida</subject><subject>Candida albicans - drug effects</subject><subject>Candida albicans - growth & development</subject><subject>Chlorhexidine</subject><subject>Chlorhexidine - administration & dosage</subject><subject>Drug Delivery Systems</subject><subject>Drug Resistance, Fungal</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Intra-oral</subject><subject>Materials Testing</subject><subject>Medical sciences</subject><subject>Methacrylates</subject><subject>Methylmethacrylates</subject><subject>PEM/THFM</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymeric delivery system</subject><subject>Polymers</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkFtLBCEUgCWK2i4_oZiHiHqY8jg66lNEdIOgh-pZXOdYxlw2nQ3232ftUr2Fghz8zu0jZB_oKVCozx4pcFbqGtgxpSeUVrUs5RqZgJKqFJqKdTL5QbbIdkpvNMeUs02yBSAAKFMTcn1RzIZ20WEMrkiLNGJX-CEW4ysWoR-jLYdo26LBNnxgXBSDL2yf7xhKP-9f8pd9wX7cJRvetgn3Vu8Oeb6-erq8Le8fbu4uL-5Lx5UcSy9txaaUa84FohSusRoE176qtZ8yyZTjjVON0qxu-BQq8EpyQFc74Zhw1Q45WtadxeF9jmk0XUgO29b2OMyTkXmtqs7nP5DVSgIXKoNiCbo4pBTRm1kMnY0LA9R8mTbfps2XRkOp-TZtZM47WDWYTztsfrNWajNwuAJscrb10fYupD8caMZ1xs6XGGZtHwGjSS5g77AJEd1omiH8M8knZPKYxA</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>Patel, M.P</creator><creator>Cruchley, A.T</creator><creator>Coleman, D.C</creator><creator>Swai, H</creator><creator>Braden, M</creator><creator>Williams, D.M</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>7X8</scope></search><sort><creationdate>20010901</creationdate><title>A polymeric system for the intra-oral delivery of an anti-fungal agent</title><author>Patel, M.P ; Cruchley, A.T ; Coleman, D.C ; Swai, H ; Braden, M ; Williams, D.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-f7a32b049445ee75cda91549f369fb2728c4dc8d8926d4b131f8741ec6c5c25c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Biocompatible Materials</topic><topic>Biological and medical sciences</topic><topic>Candida</topic><topic>Candida albicans - drug effects</topic><topic>Candida albicans - growth & development</topic><topic>Chlorhexidine</topic><topic>Chlorhexidine - administration & dosage</topic><topic>Drug Delivery Systems</topic><topic>Drug Resistance, Fungal</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Intra-oral</topic><topic>Materials Testing</topic><topic>Medical sciences</topic><topic>Methacrylates</topic><topic>Methylmethacrylates</topic><topic>PEM/THFM</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymeric delivery system</topic><topic>Polymers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, M.P</creatorcontrib><creatorcontrib>Cruchley, A.T</creatorcontrib><creatorcontrib>Coleman, D.C</creatorcontrib><creatorcontrib>Swai, H</creatorcontrib><creatorcontrib>Braden, M</creatorcontrib><creatorcontrib>Williams, D.M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, M.P</au><au>Cruchley, A.T</au><au>Coleman, D.C</au><au>Swai, H</au><au>Braden, M</au><au>Williams, D.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A polymeric system for the intra-oral delivery of an anti-fungal agent</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>22</volume><issue>17</issue><spage>2319</spage><epage>2324</epage><pages>2319-2324</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Oral candidal infections are often persistent and intractable and thus the aim of this study was to develop a polymeric sustained release device to improve the topical treatment of these infections. A self curing system based on poly(ethyl methacrylate) and tetrahydrofurfuryl methacrylate (PEM/THFM) was used with chlorhexidine diacetate (CX) added at levels between 0 and 12% w/w. Water uptake by the device was assessed gravimetrically and CX release measured by UV spectrometry. Anti candidal activity was established by culturing azole sensitive and resistant strains of
Candida albicans in the presence of the polymeric delivery device with and without CX. Candidal growth was measured by turbidimetry or surviving colony-forming unit (CFU) formation. There was an initial high release of CX over 24
h followed by a slow diffusion up to 7 days. CX inhibited candidal growth and survival markedly in vitro
, with the test samples showing less than 0.5×10
−7
CFU/ml compared to controls (3–4×10
−7
CFU/ml). These results indicate the potential of a chlorhexidine containing PEM/THFM polymeric system in the treatment of persistent candidal infections.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>11511028</pmid><doi>10.1016/S0142-9612(00)00367-7</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-9612 |
| ispartof | Biomaterials, 2001-09, Vol.22 (17), p.2319-2324 |
| issn | 0142-9612 1878-5905 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Oral Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - administration & dosage Biocompatible Materials Biological and medical sciences Candida Candida albicans - drug effects Candida albicans - growth & development Chlorhexidine Chlorhexidine - administration & dosage Drug Delivery Systems Drug Resistance, Fungal Humans In Vitro Techniques Intra-oral Materials Testing Medical sciences Methacrylates Methylmethacrylates PEM/THFM Pharmacology. Drug treatments Polymeric delivery system Polymers |
| title | A polymeric system for the intra-oral delivery of an anti-fungal agent |
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