Inhibitory Effect of Glycyrrhizin on the Phosphorylation and DNA-Binding Abilities of High Mobility Group Proteins 1 and 2 in Vitro

The physiological correlation between glycyrrhizin (GL) and high mobility group proteins 1 and 2 (HMG1/2) and the inhibitory effect of GL on their phosphorylation by three protein kinases (CK-I, CK-II and PKC) were investigated biochemically in vitro. It was found that GL binds directly to HMG1/2, b...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2001, Vol.24(8), pp.906-911
Hauptverfasser:	SAKAMOTO, Ryoko, OKANO, Maiko, TAKENA, Hiroko, OHTSUKI, Kenzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals casein kinase I Chromatography, Gas Circular Dichroism Creatine Kinase - metabolism DNA - metabolism DNA-binding ability GL-binding protein Glycyrrhetinic Acid - metabolism Glycyrrhizic Acid - pharmacology glycyrrhizin high mobility group protein High Mobility Group Proteins - antagonists & inhibitors High Mobility Group Proteins - metabolism Humans Phosphorylation - drug effects Protein Conformation protein kinase C Protein Kinase C - metabolism Rats Thymus Gland - chemistry
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