Mechanism of Neomycin and Rev Peptide Binding to the Rev Responsive Element of HIV-1 As Determined by Fluorescence and NMR Spectroscopy

Rev is an essential HIV-1 regulatory protein that binds the Rev responsive element (RRE) within the env gene of the HIV-1 RNA genome and is involved in transport of unspliced or partially spliced viral mRNA from the cell nucleus to the cytoplasm. Previous studies have shown that a short α-helical pe...

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Veröffentlicht in:	Biochemistry (Easton) 2000-05, Vol.39 (19), p.5630-5641
Hauptverfasser:	Lacourciere, Karen A, Stivers, James T, Marino, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminopurine - chemistry AIDS/HIV Amino Acid Sequence Anti-Bacterial Agents - metabolism Binding, Competitive - genetics env gene Framycetin - metabolism Gene Products, rev - antagonists & inhibitors Gene Products, rev - genetics Gene Products, rev - metabolism HIV-1 - genetics HIV-1 - metabolism Human immunodeficiency virus 1 Kinetics Molecular Sequence Data neomycin Nuclear Magnetic Resonance, Biomolecular Peptide Fragments - antagonists & inhibitors Peptide Fragments - genetics Peptide Fragments - metabolism Protein Binding - genetics Response Elements rev Gene Products, Human Immunodeficiency Virus Rev protein rev-responsive element Spectrometry, Fluorescence Thermodynamics
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