Expression of proinflammatory cytokines and their inhibitors during the course of spontaneous bacterial peritonitis
The aim of this work was the evaluation, in cirrhotic patients with noninfected ascites and with spontaneous bacterial peritonitis (SBP), of serum and ascitic fluid levels of proinflammatory cytokines [interleukin (IL) 1-beta, tumor necrosis factor alpha (TNF-alpha), and IL6] and antiinflammatory co...
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| Veröffentlicht in: | Digestive diseases and sciences 2001-08, Vol.46 (8), p.1668-1676 |
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| creator | RODRIGUEZ-RAMOS, Claudio GALAN, Fatima DIAZ, Fernando ELVIRA, Javier MARTIN-HERRERA, Leopoldo GIRON-GONZALEZ, José A |
| description | The aim of this work was the evaluation, in cirrhotic patients with noninfected ascites and with spontaneous bacterial peritonitis (SBP), of serum and ascitic fluid levels of proinflammatory cytokines [interleukin (IL) 1-beta, tumor necrosis factor alpha (TNF-alpha), and IL6] and antiinflammatory compounds [IL10, soluble IL-1 receptor antagonist (sIL-1Ra), soluble receptors of TNF p55 and p75 (sTNFR55 and sTNFR75), and soluble receptor of IL6 (sIL6R)], as well as their relationship with the outcome of the infection in those with SBP. These molecules were assayed by ELISA in noninfected cirrhotic controls (n = 15), patients with SBP (n = 32), and healthy controls (n = 20). Serum levels of IL6 and of the majority of antiinflammatory mediators, sIL1Ra, sTNFR75, and sIL6R, were higher in control cirrhotic patients compared to healthy subjects. SBP was associated with significantly elevated ascitic fluid levels of every one of the proinflammatory cytokines compared to those in cirrhotic controls. Also, serum levels of IL10 and both TNF receptors and ascitic fluid levels of sIL1Ra and sTNFR55 were higher in patients with SBP compared to cirrhotic controls. Ascitic fluid levels of proinflammatory cytokines decreased rapidly after resolution of the infection; however, nonsignificant changes were detected in ascitic fluid concentrations of antiinflammatory molecules. Thus, elevated levels of antiinflammatory compounds both in noninfected cirrhotic patients and in patients with SBP suggest a regulatory control of the inflammatory process by these molecules in liver cirrhosis patients. |
| doi_str_mv | 10.1023/A:1010645302750 |
| format | Article |
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These molecules were assayed by ELISA in noninfected cirrhotic controls (n = 15), patients with SBP (n = 32), and healthy controls (n = 20). Serum levels of IL6 and of the majority of antiinflammatory mediators, sIL1Ra, sTNFR75, and sIL6R, were higher in control cirrhotic patients compared to healthy subjects. SBP was associated with significantly elevated ascitic fluid levels of every one of the proinflammatory cytokines compared to those in cirrhotic controls. Also, serum levels of IL10 and both TNF receptors and ascitic fluid levels of sIL1Ra and sTNFR55 were higher in patients with SBP compared to cirrhotic controls. Ascitic fluid levels of proinflammatory cytokines decreased rapidly after resolution of the infection; however, nonsignificant changes were detected in ascitic fluid concentrations of antiinflammatory molecules. Thus, elevated levels of antiinflammatory compounds both in noninfected cirrhotic patients and in patients with SBP suggest a regulatory control of the inflammatory process by these molecules in liver cirrhosis patients.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1023/A:1010645302750</identifier><identifier>PMID: 11508666</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Antigens, CD - analysis ; Ascitic Fluid - chemistry ; Bacterial Infections - complications ; Bacterial Infections - metabolism ; Biological and medical sciences ; Cytokines - analysis ; Cytokines - antagonists & inhibitors ; Digestive system ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Inflammation Mediators - analysis ; Inflammation Mediators - antagonists & inhibitors ; Interleukin 1 Receptor Antagonist Protein ; Interleukin-1 - analysis ; Interleukin-10 - analysis ; Interleukin-6 - analysis ; Investigative techniques, diagnostic techniques (general aspects) ; Liver Cirrhosis - complications ; Male ; Medical sciences ; Middle Aged ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Peritonitis - complications ; Peritonitis - metabolism ; Receptors, Tumor Necrosis Factor - analysis ; Receptors, Tumor Necrosis Factor, Type I ; Receptors, Tumor Necrosis Factor, Type II ; Sialoglycoproteins - analysis ; Tumor Necrosis Factor-alpha - analysis</subject><ispartof>Digestive diseases and sciences, 2001-08, Vol.46 (8), p.1668-1676</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Kluwer Academic Publishers Aug 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c309t-84e6a86b256a568691f65d19f10f28d6259f75993aee4637c37f0b3168a3c5fb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1099881$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11508666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RODRIGUEZ-RAMOS, Claudio</creatorcontrib><creatorcontrib>GALAN, Fatima</creatorcontrib><creatorcontrib>DIAZ, Fernando</creatorcontrib><creatorcontrib>ELVIRA, Javier</creatorcontrib><creatorcontrib>MARTIN-HERRERA, Leopoldo</creatorcontrib><creatorcontrib>GIRON-GONZALEZ, José A</creatorcontrib><title>Expression of proinflammatory cytokines and their inhibitors during the course of spontaneous bacterial peritonitis</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>The aim of this work was the evaluation, in cirrhotic patients with noninfected ascites and with spontaneous bacterial peritonitis (SBP), of serum and ascitic fluid levels of proinflammatory cytokines [interleukin (IL) 1-beta, tumor necrosis factor alpha (TNF-alpha), and IL6] and antiinflammatory compounds [IL10, soluble IL-1 receptor antagonist (sIL-1Ra), soluble receptors of TNF p55 and p75 (sTNFR55 and sTNFR75), and soluble receptor of IL6 (sIL6R)], as well as their relationship with the outcome of the infection in those with SBP. These molecules were assayed by ELISA in noninfected cirrhotic controls (n = 15), patients with SBP (n = 32), and healthy controls (n = 20). Serum levels of IL6 and of the majority of antiinflammatory mediators, sIL1Ra, sTNFR75, and sIL6R, were higher in control cirrhotic patients compared to healthy subjects. SBP was associated with significantly elevated ascitic fluid levels of every one of the proinflammatory cytokines compared to those in cirrhotic controls. Also, serum levels of IL10 and both TNF receptors and ascitic fluid levels of sIL1Ra and sTNFR55 were higher in patients with SBP compared to cirrhotic controls. Ascitic fluid levels of proinflammatory cytokines decreased rapidly after resolution of the infection; however, nonsignificant changes were detected in ascitic fluid concentrations of antiinflammatory molecules. Thus, elevated levels of antiinflammatory compounds both in noninfected cirrhotic patients and in patients with SBP suggest a regulatory control of the inflammatory process by these molecules in liver cirrhosis patients.</description><subject>Antigens, CD - analysis</subject><subject>Ascitic Fluid - chemistry</subject><subject>Bacterial Infections - complications</subject><subject>Bacterial Infections - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cytokines - analysis</subject><subject>Cytokines - antagonists & inhibitors</subject><subject>Digestive system</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation Mediators - analysis</subject><subject>Inflammation Mediators - antagonists & inhibitors</subject><subject>Interleukin 1 Receptor Antagonist Protein</subject><subject>Interleukin-1 - analysis</subject><subject>Interleukin-10 - analysis</subject><subject>Interleukin-6 - analysis</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver Cirrhosis - complications</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Peritonitis - complications</subject><subject>Peritonitis - metabolism</subject><subject>Receptors, Tumor Necrosis Factor - analysis</subject><subject>Receptors, Tumor Necrosis Factor, Type I</subject><subject>Receptors, Tumor Necrosis Factor, Type II</subject><subject>Sialoglycoproteins - analysis</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkEtLxTAQhYMoen2s3UkQcXc10zRp4k7EFwhudF3SNNFom9QkBe-_N-IVwdUMMx-Hcw5Ch0DOgFT0_PICCBBeM0qqhpENtADW0GXFuNhECwK87AB8B-2m9EYIkQ3wbbQDwIjgnC9Quv6coknJBY-DxVMMzttBjaPKIa6wXuXw7rxJWPke51fjInb-1XWuvBPu5-j8y_cd6zDHZL410hR8Vt6EOeFO6WyiUwOeysjBu-zSPtqyakjmYD330PPN9dPV3fLh8fb-6vJhqSmReSlqw5XgXQmjSh4uwXLWg7RAbCV6XjFpGyYlVcbUnDaaNpZ0FLhQVDPb0T10-qNbUn3MJuV2dEmbYfgx1zZQOmwqWcDjf-BbSeOLt7aCmhZG1AU6WkNzN5q-naIbVVy1v10W4GQNqKTVYKPy2qU_jkgpBNAv4_WEOg</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>RODRIGUEZ-RAMOS, Claudio</creator><creator>GALAN, Fatima</creator><creator>DIAZ, Fernando</creator><creator>ELVIRA, Javier</creator><creator>MARTIN-HERRERA, Leopoldo</creator><creator>GIRON-GONZALEZ, José A</creator><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Expression of proinflammatory cytokines and their inhibitors during the course of spontaneous bacterial peritonitis</title><author>RODRIGUEZ-RAMOS, Claudio ; GALAN, Fatima ; DIAZ, Fernando ; ELVIRA, Javier ; MARTIN-HERRERA, Leopoldo ; GIRON-GONZALEZ, José A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-84e6a86b256a568691f65d19f10f28d6259f75993aee4637c37f0b3168a3c5fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Antigens, CD - analysis</topic><topic>Ascitic Fluid - chemistry</topic><topic>Bacterial Infections - complications</topic><topic>Bacterial Infections - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cytokines - analysis</topic><topic>Cytokines - antagonists & inhibitors</topic><topic>Digestive system</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation Mediators - analysis</topic><topic>Inflammation Mediators - antagonists & inhibitors</topic><topic>Interleukin 1 Receptor Antagonist Protein</topic><topic>Interleukin-1 - analysis</topic><topic>Interleukin-10 - analysis</topic><topic>Interleukin-6 - analysis</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Liver Cirrhosis - complications</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Peritonitis - complications</topic><topic>Peritonitis - metabolism</topic><topic>Receptors, Tumor Necrosis Factor - analysis</topic><topic>Receptors, Tumor Necrosis Factor, Type I</topic><topic>Receptors, Tumor Necrosis Factor, Type II</topic><topic>Sialoglycoproteins - analysis</topic><topic>Tumor Necrosis Factor-alpha - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RODRIGUEZ-RAMOS, Claudio</creatorcontrib><creatorcontrib>GALAN, Fatima</creatorcontrib><creatorcontrib>DIAZ, Fernando</creatorcontrib><creatorcontrib>ELVIRA, Javier</creatorcontrib><creatorcontrib>MARTIN-HERRERA, Leopoldo</creatorcontrib><creatorcontrib>GIRON-GONZALEZ, José A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RODRIGUEZ-RAMOS, Claudio</au><au>GALAN, Fatima</au><au>DIAZ, Fernando</au><au>ELVIRA, Javier</au><au>MARTIN-HERRERA, Leopoldo</au><au>GIRON-GONZALEZ, José A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of proinflammatory cytokines and their inhibitors during the course of spontaneous bacterial peritonitis</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>46</volume><issue>8</issue><spage>1668</spage><epage>1676</epage><pages>1668-1676</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>The aim of this work was the evaluation, in cirrhotic patients with noninfected ascites and with spontaneous bacterial peritonitis (SBP), of serum and ascitic fluid levels of proinflammatory cytokines [interleukin (IL) 1-beta, tumor necrosis factor alpha (TNF-alpha), and IL6] and antiinflammatory compounds [IL10, soluble IL-1 receptor antagonist (sIL-1Ra), soluble receptors of TNF p55 and p75 (sTNFR55 and sTNFR75), and soluble receptor of IL6 (sIL6R)], as well as their relationship with the outcome of the infection in those with SBP. These molecules were assayed by ELISA in noninfected cirrhotic controls (n = 15), patients with SBP (n = 32), and healthy controls (n = 20). Serum levels of IL6 and of the majority of antiinflammatory mediators, sIL1Ra, sTNFR75, and sIL6R, were higher in control cirrhotic patients compared to healthy subjects. SBP was associated with significantly elevated ascitic fluid levels of every one of the proinflammatory cytokines compared to those in cirrhotic controls. Also, serum levels of IL10 and both TNF receptors and ascitic fluid levels of sIL1Ra and sTNFR55 were higher in patients with SBP compared to cirrhotic controls. Ascitic fluid levels of proinflammatory cytokines decreased rapidly after resolution of the infection; however, nonsignificant changes were detected in ascitic fluid concentrations of antiinflammatory molecules. Thus, elevated levels of antiinflammatory compounds both in noninfected cirrhotic patients and in patients with SBP suggest a regulatory control of the inflammatory process by these molecules in liver cirrhosis patients.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>11508666</pmid><doi>10.1023/A:1010645302750</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Antigens, CD - analysis Ascitic Fluid - chemistry Bacterial Infections - complications Bacterial Infections - metabolism Biological and medical sciences Cytokines - analysis Cytokines - antagonists & inhibitors Digestive system Enzyme-Linked Immunosorbent Assay Female Humans Inflammation Mediators - analysis Inflammation Mediators - antagonists & inhibitors Interleukin 1 Receptor Antagonist Protein Interleukin-1 - analysis Interleukin-10 - analysis Interleukin-6 - analysis Investigative techniques, diagnostic techniques (general aspects) Liver Cirrhosis - complications Male Medical sciences Middle Aged Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Peritonitis - complications Peritonitis - metabolism Receptors, Tumor Necrosis Factor - analysis Receptors, Tumor Necrosis Factor, Type I Receptors, Tumor Necrosis Factor, Type II Sialoglycoproteins - analysis Tumor Necrosis Factor-alpha - analysis |
| title | Expression of proinflammatory cytokines and their inhibitors during the course of spontaneous bacterial peritonitis |
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