Ligand-binding affinity of the type 1 and 2 inositol 1,4,5-trisphosphate receptors: effect of the membrane environment

The inositol 1,4,5-trisphosphate (InsP 3) receptor is essential for Ca 2+ release from intracellular stores. There are three InsP 3 receptor types which are targets for several types of regulation. Ca 2+, phosphorylation, and protein–protein interactions may contribute to the complex pattern of the...

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