Unmyelinated nerve fiber degeneration in chronic inflammatory demyelinating polyneuropathy
To determine whether unmyelinated nerve fibers escape degeneration as one might expect in an immune response exclusively directed at myelin, we performed a morphometric examination of unmyelinated axons and myelinated nerve fibers in sural nerve biopsy specimens of 14 patients with a chronic inflamm...
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| Veröffentlicht in: | Acta neuropathologica 2000-05, Vol.99 (5), p.571-578 |
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| container_title | Acta neuropathologica |
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| creator | BOSBOOM, W. M. J VAN DEN BERG, L. H DIEKS, H. J. G PLANTE, E VELDMAN, H FRANSSEN, H WOKKE, J. H. J |
| description | To determine whether unmyelinated nerve fibers escape degeneration as one might expect in an immune response exclusively directed at myelin, we performed a morphometric examination of unmyelinated axons and myelinated nerve fibers in sural nerve biopsy specimens of 14 patients with a chronic inflammatory demyelinating polyneuropathy (CIDP) and of 12 age-matched normal controls. The numbers of unmyelinated axons, myelinated nerve fibers, denervated Schwann cell units and collagen pockets were quantified and related to the clinical and electrophysiological data of the patients with CIDP. In 4 patients with a rapid onset of the neuropathy and a highly elevated CSF protein, the numbers of both unmyelinated axons and myelinated nerve fibers were decreased equally. In 8 patients we found that the unmyelinated axons were relatively spared compared with the loss of myelinated nerve fibers. In these patients, however, the presence of denervated Schwann cell units and of collagen pockets was increased. We conclude that unmyelinated nerve fibers are affected in patients with CIDP. |
| doi_str_mv | 10.1007/s004010051162 |
| format | Article |
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M. J ; VAN DEN BERG, L. H ; DIEKS, H. J. G ; PLANTE, E ; VELDMAN, H ; FRANSSEN, H ; WOKKE, J. H. J</creator><creatorcontrib>BOSBOOM, W. M. J ; VAN DEN BERG, L. H ; DIEKS, H. J. G ; PLANTE, E ; VELDMAN, H ; FRANSSEN, H ; WOKKE, J. H. J</creatorcontrib><description>To determine whether unmyelinated nerve fibers escape degeneration as one might expect in an immune response exclusively directed at myelin, we performed a morphometric examination of unmyelinated axons and myelinated nerve fibers in sural nerve biopsy specimens of 14 patients with a chronic inflammatory demyelinating polyneuropathy (CIDP) and of 12 age-matched normal controls. The numbers of unmyelinated axons, myelinated nerve fibers, denervated Schwann cell units and collagen pockets were quantified and related to the clinical and electrophysiological data of the patients with CIDP. In 4 patients with a rapid onset of the neuropathy and a highly elevated CSF protein, the numbers of both unmyelinated axons and myelinated nerve fibers were decreased equally. In 8 patients we found that the unmyelinated axons were relatively spared compared with the loss of myelinated nerve fibers. In these patients, however, the presence of denervated Schwann cell units and of collagen pockets was increased. We conclude that unmyelinated nerve fibers are affected in patients with CIDP.</description><identifier>ISSN: 0001-6322</identifier><identifier>EISSN: 1432-0533</identifier><identifier>DOI: 10.1007/s004010051162</identifier><identifier>PMID: 10805103</identifier><identifier>CODEN: ANPTAL</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Aged ; Axons ; Biological and medical sciences ; Biopsy ; Cerebrospinal fluid ; Collagen ; Collagen - analysis ; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction ; Degeneration ; Demyelination ; Electrophysiology ; Female ; Fibers ; Humans ; Inflammation ; Male ; Medical sciences ; Middle Aged ; Myelin ; Myelin Sheath - pathology ; Nerve Degeneration - pathology ; Nerve Fibers - pathology ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropathy ; Polyneuropathy ; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - pathology ; Schwann Cells - chemistry ; Schwann Cells - pathology ; Sural nerve ; Sural Nerve - pathology ; Sural Nerve - physiopathology</subject><ispartof>Acta neuropathologica, 2000-05, Vol.99 (5), p.571-578</ispartof><rights>2000 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2000.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c346t-6d544156b04e2271ab70ad744f7078f452406f666b2bd01742e6dd603c4c93273</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1330360$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10805103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOSBOOM, W. M. J</creatorcontrib><creatorcontrib>VAN DEN BERG, L. H</creatorcontrib><creatorcontrib>DIEKS, H. J. G</creatorcontrib><creatorcontrib>PLANTE, E</creatorcontrib><creatorcontrib>VELDMAN, H</creatorcontrib><creatorcontrib>FRANSSEN, H</creatorcontrib><creatorcontrib>WOKKE, J. H. J</creatorcontrib><title>Unmyelinated nerve fiber degeneration in chronic inflammatory demyelinating polyneuropathy</title><title>Acta neuropathologica</title><addtitle>Acta Neuropathol</addtitle><description>To determine whether unmyelinated nerve fibers escape degeneration as one might expect in an immune response exclusively directed at myelin, we performed a morphometric examination of unmyelinated axons and myelinated nerve fibers in sural nerve biopsy specimens of 14 patients with a chronic inflammatory demyelinating polyneuropathy (CIDP) and of 12 age-matched normal controls. The numbers of unmyelinated axons, myelinated nerve fibers, denervated Schwann cell units and collagen pockets were quantified and related to the clinical and electrophysiological data of the patients with CIDP. In 4 patients with a rapid onset of the neuropathy and a highly elevated CSF protein, the numbers of both unmyelinated axons and myelinated nerve fibers were decreased equally. In 8 patients we found that the unmyelinated axons were relatively spared compared with the loss of myelinated nerve fibers. In these patients, however, the presence of denervated Schwann cell units and of collagen pockets was increased. We conclude that unmyelinated nerve fibers are affected in patients with CIDP.</description><subject>Adult</subject><subject>Aged</subject><subject>Axons</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cerebrospinal fluid</subject><subject>Collagen</subject><subject>Collagen - analysis</subject><subject>Cranial nerves. 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Olfaction</subject><subject>Degeneration</subject><subject>Demyelination</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>Fibers</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myelin</subject><subject>Myelin Sheath - pathology</subject><subject>Nerve Degeneration - pathology</subject><subject>Nerve Fibers - pathology</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropathy</subject><subject>Polyneuropathy</subject><subject>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - pathology</subject><subject>Schwann Cells - chemistry</subject><subject>Schwann Cells - pathology</subject><subject>Sural nerve</subject><subject>Sural Nerve - pathology</subject><subject>Sural Nerve - physiopathology</subject><issn>0001-6322</issn><issn>1432-0533</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0EtLAzEQB_Agiq3Vo1dZULytTh6b1KMUX1DwYi9elmySbVN2k5rsCvvtTWnFxykz8Jth8kfoHMMNBhC3EYBBqgqMOTlAY8woyaGg9BCNAQDnnBIyQicxrlNHBCuO0QjDNA0AHaP3hWsH01gnO6MzZ8KnyWpbmZBpszSpl531LrMuU6vgnVWprBvZtrLzYUjoe9q6ZbbxzeBMH_xGdqvhFB3VsonmbP9O0OLx4W32nM9fn15m9_NcUca7nOuCMVzwCpghRGBZCZBaMFYLENOaFYQBrznnFak0YMGI4VpzoIqpO0oEnaDr3d5N8B-9iV3Z2qhM00hnfB9LgVM8jG_h5T-49n1w6baSpAsKgTkmSeU7pYKPMZi63ATbyjCUGMpt5OWfyJO_2G_tq9boX3qXcQJXeyCjkk0dpFM2_jhKgabvfAGOa4el</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>BOSBOOM, W. 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Olfaction</topic><topic>Degeneration</topic><topic>Demyelination</topic><topic>Electrophysiology</topic><topic>Female</topic><topic>Fibers</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myelin</topic><topic>Myelin Sheath - pathology</topic><topic>Nerve Degeneration - pathology</topic><topic>Nerve Fibers - pathology</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropathy</topic><topic>Polyneuropathy</topic><topic>Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - pathology</topic><topic>Schwann Cells - chemistry</topic><topic>Schwann Cells - pathology</topic><topic>Sural nerve</topic><topic>Sural Nerve - pathology</topic><topic>Sural Nerve - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOSBOOM, W. M. J</creatorcontrib><creatorcontrib>VAN DEN BERG, L. 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M. J</au><au>VAN DEN BERG, L. H</au><au>DIEKS, H. J. G</au><au>PLANTE, E</au><au>VELDMAN, H</au><au>FRANSSEN, H</au><au>WOKKE, J. H. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unmyelinated nerve fiber degeneration in chronic inflammatory demyelinating polyneuropathy</atitle><jtitle>Acta neuropathologica</jtitle><addtitle>Acta Neuropathol</addtitle><date>2000-05-01</date><risdate>2000</risdate><volume>99</volume><issue>5</issue><spage>571</spage><epage>578</epage><pages>571-578</pages><issn>0001-6322</issn><eissn>1432-0533</eissn><coden>ANPTAL</coden><abstract>To determine whether unmyelinated nerve fibers escape degeneration as one might expect in an immune response exclusively directed at myelin, we performed a morphometric examination of unmyelinated axons and myelinated nerve fibers in sural nerve biopsy specimens of 14 patients with a chronic inflammatory demyelinating polyneuropathy (CIDP) and of 12 age-matched normal controls. The numbers of unmyelinated axons, myelinated nerve fibers, denervated Schwann cell units and collagen pockets were quantified and related to the clinical and electrophysiological data of the patients with CIDP. In 4 patients with a rapid onset of the neuropathy and a highly elevated CSF protein, the numbers of both unmyelinated axons and myelinated nerve fibers were decreased equally. In 8 patients we found that the unmyelinated axons were relatively spared compared with the loss of myelinated nerve fibers. In these patients, however, the presence of denervated Schwann cell units and of collagen pockets was increased. We conclude that unmyelinated nerve fibers are affected in patients with CIDP.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>10805103</pmid><doi>10.1007/s004010051162</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Axons Biological and medical sciences Biopsy Cerebrospinal fluid Collagen Collagen - analysis Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Degeneration Demyelination Electrophysiology Female Fibers Humans Inflammation Male Medical sciences Middle Aged Myelin Myelin Sheath - pathology Nerve Degeneration - pathology Nerve Fibers - pathology Nervous system (semeiology, syndromes) Neurology Neuropathy Polyneuropathy Polyradiculoneuropathy, Chronic Inflammatory Demyelinating - pathology Schwann Cells - chemistry Schwann Cells - pathology Sural nerve Sural Nerve - pathology Sural Nerve - physiopathology |
| title | Unmyelinated nerve fiber degeneration in chronic inflammatory demyelinating polyneuropathy |
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