Interleukin-10 inhibition of gelatinases in fetal membranes: therapeutic implications in preterm premature rupture of membranes

OBJECTIVE: To examine the effect of interleukin-10 on production and regulation of gelatinases by amniochorion in an in vitro model of infection. METHODS: We placed amniochorionic membranes collected from eight women who had elective repeat cesareans at term in an organ explant culture system. After...

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Veröffentlicht in:	Obstetrics and gynecology (New York. 1953) 2001-08, Vol.98 (2), p.284-288
Hauptverfasser:	Fortunato, Stephen J, Menon, Ramkumar, Lombardi, Salvatore J, LaFleur, Bonnie
Format:	Artikel
Sprache:	eng
Schlagworte:	Amnion - enzymology Biological and medical sciences Chorioamnionitis - enzymology Chorion - enzymology Culture Techniques Diseases of mother, fetus and pregnancy Enzyme Induction Enzyme-Linked Immunosorbent Assay Escherichia coli Female Fetal Membranes, Premature Rupture - enzymology Fetal Membranes, Premature Rupture - prevention & control Gynecology. Andrology. Obstetrics Humans Interleukin-10 - pharmacology Interleukin-10 - therapeutic use Lipopolysaccharides - pharmacology Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 9 - biosynthesis Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase Inhibitors Medical sciences Pregnancy Pregnancy Complications, Infectious - enzymology Pregnancy. Fetus. Placenta Recombinant Proteins - pharmacology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis
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