Inflammatory Cytokines Enhance Muscarinic‐Mediated Arachidonic Acid Release Through p38 Mitogen‐Activated Protein Kinase in A2058 Cells

: The human melanoma cell line A2058 expresses the Gq‐coupled M5 subtype of muscarinic receptor. Stimulation with the cholinergic agonist, carbachol, induces a dose‐dependent increase in arachidonic acid release. The carbachol‐induced arachidonate release is potentiated two‐ to threefold by pretreat...

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Veröffentlicht in:	Journal of neurochemistry 2000-05, Vol.74 (5), p.2033-2040
Hauptverfasser:	Wood, Michael W., Segal, Jeff A., Mark, Robert J., Ogden, Ann Marie, Felder, Christian C.
Format:	Artikel
Sprache:	eng
Schlagworte:	A2058 cells Animals Anisomycin - pharmacology Arachidonic acid Arachidonic Acid - metabolism Biological and medical sciences Carbachol - pharmacology Cerebellum - cytology Cerebellum - metabolism Cerebral Cortex - cytology Cerebral Cortex - metabolism Cholinergic Agonists - pharmacology Cytokines Cytokines - pharmacology Enzyme Activation Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Humans Imidazoles - pharmacology Inflammation Mediators - pharmacology Interleukin-1 - pharmacology Isolated neuron and nerve. Neuroglia melanoma cells Mitogen-Activated Protein Kinases - metabolism Mitogen‐activated protein kinase Muscarine - metabolism Muscarinic receptor NF-kappa B - physiology p38 Mitogen-Activated Protein Kinases Pyridines - pharmacology Rats Tumor Cells, Cultured Tumor Necrosis Factor-alpha - pharmacology Vertebrates: nervous system and sense organs
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