Development of the Structural Basis for Antimicrobial and Hemolytic Activities of Peptides Based on Gramicidin S and Design of Novel Analogs Using NMR Spectroscopy

The structures of 14-residue head-to-tail cyclic gramicidin S peptides have been investigated to develop the structural rationale for their antimicrobial and hemolytic profiles. The basis for these studies is GS14 (cyclo(VKLKVdYPLKVKLdYP)), designed as an extension of the naturally occurring antimic...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	The Journal of biological chemistry 2000-05, Vol.275 (19), p.14287-14294
Hauptverfasser:	McInnes, Campbell, Kondejewski, Leslie H., Hodges, Robert S., Sykes, Brian D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Drug Design Gramicidin - analogs & derivatives gramicidin S GS14 Hemolysis - drug effects Magnetic Resonance Spectroscopy Molecular Sequence Data Protein Conformation Structure-Activity Relationship Trifluoroethanol
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!