Behavioral Phenotyping of GFAP-ApoE3 and -ApoE4 Transgenic Mice: ApoE4 Mice Show Profound Working Memory Impairments in the Absence of Alzheimer's-like Neuropathology

For the purpose of studying the potential neurobehavioral effects of different human apolipoprotein E (apoE) isoforms produced within the brain, transgenic (TG) mice were generated in which human apoE3 or apoE4 isoforms were under control of an astrocyte-specific, glial fibrillary acidic protein pro...

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Veröffentlicht in:	Experimental neurology 2001-08, Vol.170 (2), p.326-344
Hauptverfasser:	Hartman, R.E., Wozniak, D.F., Nardi, A., Olney, J.W., Sartorius, L., Holtzman, D.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation Adult and adolescent clinical studies Aging Alzheimer Disease - pathology Alzheimer's disease Analysis of Variance Animals apolipoprotein E Apolipoprotein E3 Apolipoprotein E4 Apolipoproteins E - genetics Apolipoproteins E - physiology Biological and medical sciences Cues emotionality Emotions Escape Reaction - physiology Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - physiology Humans Intellectual deficiency knockout mice Learning - physiology Male Medical sciences Memory Disorders - genetics Memory Disorders - physiopathology Memory Disorders - psychology Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Motor Activity - physiology Phenotype Promoter Regions, Genetic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reaction Time reference memory Reflex, Startle sensorimotor Space Perception - physiology spatial learning and memory Time Factors
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