Region-specific age at onset of β-amyloid in dogs
Cortical patterns of β-amyloid (Aβ) deposition were evaluated in 40 beagle dogs ranging in age from 2 to 18 years. Aβ deposition in the prefrontal, occipital, parietal and entorhinal cortices was visualized by using an antibody against Aβ1–42. A logistic regression was used to estimate differences i...
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| Veröffentlicht in: | Neurobiology of aging 2000-01, Vol.21 (1), p.89-96 |
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| creator | Head, E McCleary, R Hahn, F.F Milgram, N.W Cotman, C.W |
| description | Cortical patterns of β-amyloid (Aβ) deposition were evaluated in 40 beagle dogs ranging in age from 2 to 18 years. Aβ deposition in the prefrontal, occipital, parietal and entorhinal cortices was visualized by using an antibody against Aβ1–42. A logistic regression was used to estimate differences in age-at-onset and rate of deposition of Aβ as a function of brain region. The earliest and most consistent site of Aβ deposition with age was in the prefrontal cortex. Entorhinal Aβ deposition was not consistently observed until the age of 14 years, but was present in a subset of dogs under the age of 14 years. These regional vulnerabilities to Aβ accumulation are similar to those seen in the aging human. By using parameters derived from regression analyses, it may be possible to predict the presence of Aβ within specific brain regions in individual dogs. We propose that these models will be a useful tool to evaluate interventions that delay the age of onset or slow the rate of accumulation of Aβ in the dog. |
| doi_str_mv | 10.1016/S0197-4580(00)00093-2 |
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Aβ deposition in the prefrontal, occipital, parietal and entorhinal cortices was visualized by using an antibody against Aβ1–42. A logistic regression was used to estimate differences in age-at-onset and rate of deposition of Aβ as a function of brain region. The earliest and most consistent site of Aβ deposition with age was in the prefrontal cortex. Entorhinal Aβ deposition was not consistently observed until the age of 14 years, but was present in a subset of dogs under the age of 14 years. These regional vulnerabilities to Aβ accumulation are similar to those seen in the aging human. By using parameters derived from regression analyses, it may be possible to predict the presence of Aβ within specific brain regions in individual dogs. We propose that these models will be a useful tool to evaluate interventions that delay the age of onset or slow the rate of accumulation of Aβ in the dog.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/S0197-4580(00)00093-2</identifier><identifier>PMID: 10794853</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Aging - pathology ; Amyloid beta-Peptides - analysis ; Animals ; Biological and medical sciences ; Body Weight ; Canine model ; Cerebral Cortex - metabolism ; Cerebral Cortex - pathology ; Cortical pattern ; Development. Senescence. Regeneration. Transplantation ; Dogs ; Entorhinal Cortex - metabolism ; Entorhinal Cortex - pathology ; Female ; Fundamental and applied biological sciences. Psychology ; Immunohistochemistry ; Likelihood Functions ; Logistic Models ; Logistic regression ; Male ; Occipital Lobe - metabolism ; Occipital Lobe - pathology ; Odds Ratio ; Organ Specificity ; Parietal Lobe - metabolism ; Parietal Lobe - pathology ; Prefrontal Cortex - metabolism ; Prefrontal Cortex - pathology ; Vertebrates: nervous system and sense organs ; β-amyloid</subject><ispartof>Neurobiology of aging, 2000-01, Vol.21 (1), p.89-96</ispartof><rights>2000 Elsevier Science Inc.</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-fa636be3fa257270210e962775a0eb3fd0896afbd4de5649fec68b6fbb693e153</citedby><cites>FETCH-LOGICAL-c442t-fa636be3fa257270210e962775a0eb3fd0896afbd4de5649fec68b6fbb693e153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0197-4580(00)00093-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1400140$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10794853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Head, E</creatorcontrib><creatorcontrib>McCleary, R</creatorcontrib><creatorcontrib>Hahn, F.F</creatorcontrib><creatorcontrib>Milgram, N.W</creatorcontrib><creatorcontrib>Cotman, C.W</creatorcontrib><title>Region-specific age at onset of β-amyloid in dogs</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>Cortical patterns of β-amyloid (Aβ) deposition were evaluated in 40 beagle dogs ranging in age from 2 to 18 years. Aβ deposition in the prefrontal, occipital, parietal and entorhinal cortices was visualized by using an antibody against Aβ1–42. A logistic regression was used to estimate differences in age-at-onset and rate of deposition of Aβ as a function of brain region. The earliest and most consistent site of Aβ deposition with age was in the prefrontal cortex. Entorhinal Aβ deposition was not consistently observed until the age of 14 years, but was present in a subset of dogs under the age of 14 years. These regional vulnerabilities to Aβ accumulation are similar to those seen in the aging human. By using parameters derived from regression analyses, it may be possible to predict the presence of Aβ within specific brain regions in individual dogs. We propose that these models will be a useful tool to evaluate interventions that delay the age of onset or slow the rate of accumulation of Aβ in the dog.</description><subject>Aging - pathology</subject><subject>Amyloid beta-Peptides - analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Canine model</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cerebral Cortex - pathology</subject><subject>Cortical pattern</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Dogs</subject><subject>Entorhinal Cortex - metabolism</subject><subject>Entorhinal Cortex - pathology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunohistochemistry</subject><subject>Likelihood Functions</subject><subject>Logistic Models</subject><subject>Logistic regression</subject><subject>Male</subject><subject>Occipital Lobe - metabolism</subject><subject>Occipital Lobe - pathology</subject><subject>Odds Ratio</subject><subject>Organ Specificity</subject><subject>Parietal Lobe - metabolism</subject><subject>Parietal Lobe - pathology</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Prefrontal Cortex - pathology</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>β-amyloid</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkNtKxDAQhoMo7rr6CEovRPSiOmlzaK9EFk-wIHi4Dmk6WSI9rE1X2NfyQXwms3ZR74TJ5Ob7M5OPkEMK5xSouHgCmsuY8QxOAc4AIE_jZIuMKedZTFkut8n4BxmRPe9fAySZFLtkREHmLOPpmCSPOHdtE_sFGmedifQcI91HbeMxdBt9fsS6XlWtKyPXRGU79_tkx-rK48HmnpCXm-vn6V08e7i9n17NYsNY0sdWi1QUmFqdcJlISChgLhIpuQYsUltClgtti5KVyAXLLRqRFcIWhchTpDydkJPh3UXXvi3R96p23mBV6QbbpVeShj9TSgPIB9B0rfcdWrXoXK27laKg1rLUtyy1NqFgXSGokpA72gxYFjWWf1KDnQAcbwDtja5spxvj_C_HAMIJ2OWAYbDx7rBT3jhsDJauQ9OrsnX_bPIFnMKE5w</recordid><startdate>20000101</startdate><enddate>20000101</enddate><creator>Head, E</creator><creator>McCleary, R</creator><creator>Hahn, F.F</creator><creator>Milgram, N.W</creator><creator>Cotman, C.W</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000101</creationdate><title>Region-specific age at onset of β-amyloid in dogs</title><author>Head, E ; McCleary, R ; Hahn, F.F ; Milgram, N.W ; Cotman, C.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-fa636be3fa257270210e962775a0eb3fd0896afbd4de5649fec68b6fbb693e153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aging - pathology</topic><topic>Amyloid beta-Peptides - analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Canine model</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cerebral Cortex - pathology</topic><topic>Cortical pattern</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Dogs</topic><topic>Entorhinal Cortex - metabolism</topic><topic>Entorhinal Cortex - pathology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunohistochemistry</topic><topic>Likelihood Functions</topic><topic>Logistic Models</topic><topic>Logistic regression</topic><topic>Male</topic><topic>Occipital Lobe - metabolism</topic><topic>Occipital Lobe - pathology</topic><topic>Odds Ratio</topic><topic>Organ Specificity</topic><topic>Parietal Lobe - metabolism</topic><topic>Parietal Lobe - pathology</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Prefrontal Cortex - pathology</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>β-amyloid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Head, E</creatorcontrib><creatorcontrib>McCleary, R</creatorcontrib><creatorcontrib>Hahn, F.F</creatorcontrib><creatorcontrib>Milgram, N.W</creatorcontrib><creatorcontrib>Cotman, C.W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Head, E</au><au>McCleary, R</au><au>Hahn, F.F</au><au>Milgram, N.W</au><au>Cotman, C.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Region-specific age at onset of β-amyloid in dogs</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>2000-01-01</date><risdate>2000</risdate><volume>21</volume><issue>1</issue><spage>89</spage><epage>96</epage><pages>89-96</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>Cortical patterns of β-amyloid (Aβ) deposition were evaluated in 40 beagle dogs ranging in age from 2 to 18 years. Aβ deposition in the prefrontal, occipital, parietal and entorhinal cortices was visualized by using an antibody against Aβ1–42. A logistic regression was used to estimate differences in age-at-onset and rate of deposition of Aβ as a function of brain region. The earliest and most consistent site of Aβ deposition with age was in the prefrontal cortex. Entorhinal Aβ deposition was not consistently observed until the age of 14 years, but was present in a subset of dogs under the age of 14 years. These regional vulnerabilities to Aβ accumulation are similar to those seen in the aging human. By using parameters derived from regression analyses, it may be possible to predict the presence of Aβ within specific brain regions in individual dogs. We propose that these models will be a useful tool to evaluate interventions that delay the age of onset or slow the rate of accumulation of Aβ in the dog.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>10794853</pmid><doi>10.1016/S0197-4580(00)00093-2</doi><tpages>8</tpages></addata></record> |
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| subjects | Aging - pathology Amyloid beta-Peptides - analysis Animals Biological and medical sciences Body Weight Canine model Cerebral Cortex - metabolism Cerebral Cortex - pathology Cortical pattern Development. Senescence. Regeneration. Transplantation Dogs Entorhinal Cortex - metabolism Entorhinal Cortex - pathology Female Fundamental and applied biological sciences. Psychology Immunohistochemistry Likelihood Functions Logistic Models Logistic regression Male Occipital Lobe - metabolism Occipital Lobe - pathology Odds Ratio Organ Specificity Parietal Lobe - metabolism Parietal Lobe - pathology Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Vertebrates: nervous system and sense organs β-amyloid |
| title | Region-specific age at onset of β-amyloid in dogs |
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