Glucocorticoids impair fetal beta-cell development in rats
In rats, poor fetal growth due to maternal food restriction during pregnancy is associated with decreased beta-cell mass at birth and glucose intolerance in adulthood. Overexposure to glucocorticoids in utero can induce intrauterine growth retardation in humans and animals and subsequent glucose int...
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| Veröffentlicht in: | American journal of physiology: endocrinology and metabolism 2001-09, Vol.281 (3), p.E592-E599 |
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| container_issue | 3 |
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| container_title | American journal of physiology: endocrinology and metabolism |
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| creator | Blondeau, B Lesage, J Czernichow, P Dupouy, J P Bréant, B |
| description | In rats, poor fetal growth due to maternal food restriction during pregnancy is associated with decreased beta-cell mass at birth and glucose intolerance in adulthood. Overexposure to glucocorticoids in utero can induce intrauterine growth retardation in humans and animals and subsequent glucose intolerance in rodents. The aims of this study were to investigate whether glucocorticoid overexposure mediates the effect of undernutrition on beta-cell mass and to study their potential role in normally nourished rats. Undernutrition significantly increased maternal and fetal corticosterone levels. Twenty-one-day-old fetuses with undernutrition showed growth retardation and decreased pancreatic insulin content; adrenalectomy and subcutaneous corticosterone implants in their dams prevented the maternal corticosterone increase and restored fetal beta-cell mass. In fetuses with normal nutrition, fetal corticosterone levels were negatively correlated to fetal weight and insulin content; fetal beta-cell mass increased from 355 +/- 48 microg in sham to 516 +/- 160 microg after maternal adrenalectomy; inhibition of steroid production by metyrapone induced a further increase to 757 +/- 125 microg. Our data support the new concept of a negative role of glucocorticoids in fetal beta-cell development. |
| doi_str_mv | 10.1152/ajpendo.2001.281.3.e592 |
| format | Article |
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Overexposure to glucocorticoids in utero can induce intrauterine growth retardation in humans and animals and subsequent glucose intolerance in rodents. The aims of this study were to investigate whether glucocorticoid overexposure mediates the effect of undernutrition on beta-cell mass and to study their potential role in normally nourished rats. Undernutrition significantly increased maternal and fetal corticosterone levels. Twenty-one-day-old fetuses with undernutrition showed growth retardation and decreased pancreatic insulin content; adrenalectomy and subcutaneous corticosterone implants in their dams prevented the maternal corticosterone increase and restored fetal beta-cell mass. In fetuses with normal nutrition, fetal corticosterone levels were negatively correlated to fetal weight and insulin content; fetal beta-cell mass increased from 355 +/- 48 microg in sham to 516 +/- 160 microg after maternal adrenalectomy; inhibition of steroid production by metyrapone induced a further increase to 757 +/- 125 microg. 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Overexposure to glucocorticoids in utero can induce intrauterine growth retardation in humans and animals and subsequent glucose intolerance in rodents. The aims of this study were to investigate whether glucocorticoid overexposure mediates the effect of undernutrition on beta-cell mass and to study their potential role in normally nourished rats. Undernutrition significantly increased maternal and fetal corticosterone levels. Twenty-one-day-old fetuses with undernutrition showed growth retardation and decreased pancreatic insulin content; adrenalectomy and subcutaneous corticosterone implants in their dams prevented the maternal corticosterone increase and restored fetal beta-cell mass. In fetuses with normal nutrition, fetal corticosterone levels were negatively correlated to fetal weight and insulin content; fetal beta-cell mass increased from 355 +/- 48 microg in sham to 516 +/- 160 microg after maternal adrenalectomy; inhibition of steroid production by metyrapone induced a further increase to 757 +/- 125 microg. Our data support the new concept of a negative role of glucocorticoids in fetal beta-cell development.</description><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - embryology</subject><subject>Adrenalectomy</subject><subject>Animals</subject><subject>Corticosterone - administration & dosage</subject><subject>Corticosterone - biosynthesis</subject><subject>Corticosterone - blood</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Fetal Growth Retardation - etiology</subject><subject>Fetal Weight</subject><subject>Gestational Age</subject><subject>Glucocorticoids - physiology</subject><subject>Insulin - analysis</subject><subject>Islets of Langerhans - drug effects</subject><subject>Islets of Langerhans - embryology</subject><subject>Metyrapone - pharmacology</subject><subject>Nutrition Disorders - blood</subject><subject>Nutrition Disorders - complications</subject><subject>Pancreas - chemistry</subject><subject>Pancreas - embryology</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0193-1849</issn><issn>1522-1555</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhoMo7rr6F7Qnb62Tr03rTZZ1FRa86DmkSQpZ2qYmreC_N2ULXmaYj_ed4UHoAUOBMSdP6jTY3viCAOCClLigheUVuUDrNCU55pxfojXgiua4ZNUK3cR4AgDBGblGq-QBQDFfo-dDO2mvfRid9s7EzHWDciFr7KjarE4x17ZtM2N_bOuHzvZj5vosqDHeoqtGtdHeLXmDvl73n7u3_PhxeN-9HHNNoRpTtEyXwpaUEqFIWTegcaoYbagBobjBjLJtGlClNGChU6s0da0FbJnRdIMez75D8N-TjaPsXJyfUr31U5QCQ5UQ0LQozos6-BiDbeQQXKfCr8QgZ2xywSZnbDJpJJX7hC0p75cTU91Z869bONE_TShrPg</recordid><startdate>20010901</startdate><enddate>20010901</enddate><creator>Blondeau, B</creator><creator>Lesage, J</creator><creator>Czernichow, P</creator><creator>Dupouy, J P</creator><creator>Bréant, B</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010901</creationdate><title>Glucocorticoids impair fetal beta-cell development in rats</title><author>Blondeau, B ; Lesage, J ; Czernichow, P ; Dupouy, J P ; Bréant, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-c3e4c87e83327a28bf0c1e8343f3d07a5d1434628b3aac017ca5d8dbbc7064dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - embryology</topic><topic>Adrenalectomy</topic><topic>Animals</topic><topic>Corticosterone - administration & dosage</topic><topic>Corticosterone - biosynthesis</topic><topic>Corticosterone - blood</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Fetal Growth Retardation - etiology</topic><topic>Fetal Weight</topic><topic>Gestational Age</topic><topic>Glucocorticoids - physiology</topic><topic>Insulin - analysis</topic><topic>Islets of Langerhans - drug effects</topic><topic>Islets of Langerhans - embryology</topic><topic>Metyrapone - pharmacology</topic><topic>Nutrition Disorders - blood</topic><topic>Nutrition Disorders - complications</topic><topic>Pancreas - chemistry</topic><topic>Pancreas - embryology</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blondeau, B</creatorcontrib><creatorcontrib>Lesage, J</creatorcontrib><creatorcontrib>Czernichow, P</creatorcontrib><creatorcontrib>Dupouy, J P</creatorcontrib><creatorcontrib>Bréant, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of physiology: endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blondeau, B</au><au>Lesage, J</au><au>Czernichow, P</au><au>Dupouy, J P</au><au>Bréant, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucocorticoids impair fetal beta-cell development in rats</atitle><jtitle>American journal of physiology: endocrinology and metabolism</jtitle><addtitle>Am J Physiol Endocrinol Metab</addtitle><date>2001-09-01</date><risdate>2001</risdate><volume>281</volume><issue>3</issue><spage>E592</spage><epage>E599</epage><pages>E592-E599</pages><issn>0193-1849</issn><eissn>1522-1555</eissn><abstract>In rats, poor fetal growth due to maternal food restriction during pregnancy is associated with decreased beta-cell mass at birth and glucose intolerance in adulthood. 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In fetuses with normal nutrition, fetal corticosterone levels were negatively correlated to fetal weight and insulin content; fetal beta-cell mass increased from 355 +/- 48 microg in sham to 516 +/- 160 microg after maternal adrenalectomy; inhibition of steroid production by metyrapone induced a further increase to 757 +/- 125 microg. Our data support the new concept of a negative role of glucocorticoids in fetal beta-cell development.</abstract><cop>United States</cop><pmid>11500315</pmid><doi>10.1152/ajpendo.2001.281.3.e592</doi></addata></record> |
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| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adrenal Glands - drug effects Adrenal Glands - embryology Adrenalectomy Animals Corticosterone - administration & dosage Corticosterone - biosynthesis Corticosterone - blood Female Fetal Blood - chemistry Fetal Growth Retardation - etiology Fetal Weight Gestational Age Glucocorticoids - physiology Insulin - analysis Islets of Langerhans - drug effects Islets of Langerhans - embryology Metyrapone - pharmacology Nutrition Disorders - blood Nutrition Disorders - complications Pancreas - chemistry Pancreas - embryology Pregnancy Rats Rats, Wistar |
| title | Glucocorticoids impair fetal beta-cell development in rats |
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