Preferential Labeling of Glial and Meningial Brain Tumors with [2-14C]Acetate

Acetate is preferentially transported into and metabolized by astrocytes, rather than synaptosomes or neurons, and labeled acetate is used as a glial reporter molecule to assess glial metabolism and glial-neuronal interactions. Because monocarboxylic acid transporter specificity might confer a pheno...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2001-08, Vol.42 (8), p.1243-1250
Hauptverfasser:	Dienel, Gerald A, Popp, David, Drew, Paul D, Ball, Kelly, Krisht, Ali, Cruz, Nancy F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic Acid Animals Biological and medical sciences Biotransformation Brain - metabolism Brain Neoplasms - diagnostic imaging Carbon Radioisotopes Glioma - diagnostic imaging Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Meningioma - diagnostic imaging Neoplasm Transplantation Nervous system Neurology Radionuclide Imaging Radionuclide investigations Radiopharmaceuticals - pharmacokinetics Rats Transplantation, Heterologous Tumor Cells, Cultured Tumors of the nervous system. Phacomatoses
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