All-Trans-Retinoic Acid Decreases Vein Graft Intimal Hyperplasia and Matrix Metalloproteinase Activity in Vivo

Background. Development of vein graft intimal hyperplasia has been associated with increased activity of matrix metalloproteinases (MMPs). All-trans-retinoic acid (atRA) decreases expression and activity of MMPs in tissue culture and has decreased intimal hyperplasia following arterial balloon cathe...

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Veröffentlicht in:	The Journal of surgical research 2000-05, Vol.90 (2), p.183-190
Hauptverfasser:	Leville, Christopher D., Dassow, Michael S., Seabrook, Gary R., Jean-Claude, Jessie M., Towne, Jonathan B., Cambria, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - blood Antineoplastic Agents - pharmacology Blotting, Northern Gene Expression Regulation, Enzymologic Hyperplasia intimal hyperplasia Jugular Veins - enzymology Jugular Veins - pathology Jugular Veins - transplantation Male Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism metalloproteinase Rabbits retinoids RNA, Messenger - analysis Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-1 - metabolism Tretinoin - blood Tretinoin - pharmacology Tunica Intima - enzymology Tunica Intima - pathology vein graft Wound Healing - drug effects
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