High proportion of unrelated HIV-1 intersubtype recombinants in the Mbeya region of southwest Tanzania
In Mbeya, a rural region of southwest Tanzania, HIV-1 subtypes A, C and D have been co-circulating since the early 1990s. To define to what extent the co-existence of subtypes has led to recombinant HIV-1 strains and whether there is evidence for epidemic spread of any circulating recombinant form....
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| Veröffentlicht in: | AIDS (London) 2001-08, Vol.15 (12), p.1461-1470 |
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| container_title | AIDS (London) |
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| creator | HOELSCHER, Michael KIM, Bohye MABOKO, Leonard MHALU, Fred VON SONNENBURG, Frank BIRX, Deborah L MCCUTCHAN, Francine E |
| description | In Mbeya, a rural region of southwest Tanzania, HIV-1 subtypes A, C and D have been co-circulating since the early 1990s.
To define to what extent the co-existence of subtypes has led to recombinant HIV-1 strains and whether there is evidence for epidemic spread of any circulating recombinant form.
Nine HIV-1-seropositive young adults from Mbeya Town with no evident high-risk behaviour contributed peripheral blood mononuclear cells for this study. Nine virtually full-length-genome-sequences were amplified from this DNA and phylogenetically analysed.
Out of the nine samples, two were subtype A (22%), two were subtype C (22%) and five were recombinants (56%): four A/C recombinants and one C/D recombinant. None of the recombinants were related to each other; all of them had different mosaic structures. Most of the genome in the recombinants was subtype C.
A high proportion of unrelated intersubtype recombinants, none of them apparently spreading in the population, may be present in southwest Tanzania. |
| doi_str_mv | 10.1097/00002030-200108170-00002 |
| format | Article |
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To define to what extent the co-existence of subtypes has led to recombinant HIV-1 strains and whether there is evidence for epidemic spread of any circulating recombinant form.
Nine HIV-1-seropositive young adults from Mbeya Town with no evident high-risk behaviour contributed peripheral blood mononuclear cells for this study. Nine virtually full-length-genome-sequences were amplified from this DNA and phylogenetically analysed.
Out of the nine samples, two were subtype A (22%), two were subtype C (22%) and five were recombinants (56%): four A/C recombinants and one C/D recombinant. None of the recombinants were related to each other; all of them had different mosaic structures. Most of the genome in the recombinants was subtype C.
A high proportion of unrelated intersubtype recombinants, none of them apparently spreading in the population, may be present in southwest Tanzania.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-200108170-00002</identifier><identifier>PMID: 11504977</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; AIDS/HIV ; Biological and medical sciences ; Female ; Genome, Viral ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - genetics ; Human immunodeficiency virus 1 ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Molecular Sequence Data ; Phylogeny ; Recombination, Genetic ; Sequence Analysis, DNA ; Tanzania ; Tropical medicine ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS (London), 2001-08, Vol.15 (12), p.1461-1470</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-3094eae21efc3b186bd5fac2159eebca49176252c9d946c5c0225ad1051b9dd63</citedby><cites>FETCH-LOGICAL-c488t-3094eae21efc3b186bd5fac2159eebca49176252c9d946c5c0225ad1051b9dd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14084763$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11504977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOELSCHER, Michael</creatorcontrib><creatorcontrib>KIM, Bohye</creatorcontrib><creatorcontrib>MABOKO, Leonard</creatorcontrib><creatorcontrib>MHALU, Fred</creatorcontrib><creatorcontrib>VON SONNENBURG, Frank</creatorcontrib><creatorcontrib>BIRX, Deborah L</creatorcontrib><creatorcontrib>MCCUTCHAN, Francine E</creatorcontrib><creatorcontrib>UNAIDS Network for HIV Isolation and Characterization</creatorcontrib><title>High proportion of unrelated HIV-1 intersubtype recombinants in the Mbeya region of southwest Tanzania</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>In Mbeya, a rural region of southwest Tanzania, HIV-1 subtypes A, C and D have been co-circulating since the early 1990s.
To define to what extent the co-existence of subtypes has led to recombinant HIV-1 strains and whether there is evidence for epidemic spread of any circulating recombinant form.
Nine HIV-1-seropositive young adults from Mbeya Town with no evident high-risk behaviour contributed peripheral blood mononuclear cells for this study. Nine virtually full-length-genome-sequences were amplified from this DNA and phylogenetically analysed.
Out of the nine samples, two were subtype A (22%), two were subtype C (22%) and five were recombinants (56%): four A/C recombinants and one C/D recombinant. None of the recombinants were related to each other; all of them had different mosaic structures. Most of the genome in the recombinants was subtype C.
A high proportion of unrelated intersubtype recombinants, none of them apparently spreading in the population, may be present in southwest Tanzania.</description><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Genome, Viral</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - genetics</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Phylogeny</subject><subject>Recombination, Genetic</subject><subject>Sequence Analysis, DNA</subject><subject>Tanzania</subject><subject>Tropical medicine</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERZfCX0C-wC0wY8exfUQVdCu16qVwjRxn0g3KOovtCC2_HtMN7ZG5jDTzzOfLGEf4iGD1JygmQEIlABAMaqgeQy_YBmstK6U0vmQbEI2trNRwzl6n9KMQCox5xc4RFdRW6w0btuPDjh_ifJhjHufA54EvIdLkMvV8e_29Qj6GTDEtXT4eiEfy874bgws5lQzPO-K3HR1dyTysDdK85N0vSpnfu_DbhdG9YWeDmxK9Xf0F-_b1y_3ltrq5u7q-_HxT-dqYXEmwNTkSSIOXHZqm69XgvEBliTrvaou6EUp429u68cqDEMr1CAo72_eNvGAfTn3LRT-XskG7H5OnaXKB5iW1urwPGi3-C6IBKwtZQHMCfZxTijS0hzjuXTy2CO1fMdp_YrRPYpxCpfTdOmPp9tQ_F67fL8D7FXDJu2mILvgxPXM1mFo3Uv4B1-WSTg</recordid><startdate>20010817</startdate><enddate>20010817</enddate><creator>HOELSCHER, Michael</creator><creator>KIM, Bohye</creator><creator>MABOKO, Leonard</creator><creator>MHALU, Fred</creator><creator>VON SONNENBURG, Frank</creator><creator>BIRX, Deborah L</creator><creator>MCCUTCHAN, Francine E</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010817</creationdate><title>High proportion of unrelated HIV-1 intersubtype recombinants in the Mbeya region of southwest Tanzania</title><author>HOELSCHER, Michael ; KIM, Bohye ; MABOKO, Leonard ; MHALU, Fred ; VON SONNENBURG, Frank ; BIRX, Deborah L ; MCCUTCHAN, Francine E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-3094eae21efc3b186bd5fac2159eebca49176252c9d946c5c0225ad1051b9dd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Genome, Viral</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - genetics</topic><topic>Human immunodeficiency virus 1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Phylogeny</topic><topic>Recombination, Genetic</topic><topic>Sequence Analysis, DNA</topic><topic>Tanzania</topic><topic>Tropical medicine</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOELSCHER, Michael</creatorcontrib><creatorcontrib>KIM, Bohye</creatorcontrib><creatorcontrib>MABOKO, Leonard</creatorcontrib><creatorcontrib>MHALU, Fred</creatorcontrib><creatorcontrib>VON SONNENBURG, Frank</creatorcontrib><creatorcontrib>BIRX, Deborah L</creatorcontrib><creatorcontrib>MCCUTCHAN, Francine E</creatorcontrib><creatorcontrib>UNAIDS Network for HIV Isolation and Characterization</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOELSCHER, Michael</au><au>KIM, Bohye</au><au>MABOKO, Leonard</au><au>MHALU, Fred</au><au>VON SONNENBURG, Frank</au><au>BIRX, Deborah L</au><au>MCCUTCHAN, Francine E</au><aucorp>UNAIDS Network for HIV Isolation and Characterization</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High proportion of unrelated HIV-1 intersubtype recombinants in the Mbeya region of southwest Tanzania</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2001-08-17</date><risdate>2001</risdate><volume>15</volume><issue>12</issue><spage>1461</spage><epage>1470</epage><pages>1461-1470</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>In Mbeya, a rural region of southwest Tanzania, HIV-1 subtypes A, C and D have been co-circulating since the early 1990s.
To define to what extent the co-existence of subtypes has led to recombinant HIV-1 strains and whether there is evidence for epidemic spread of any circulating recombinant form.
Nine HIV-1-seropositive young adults from Mbeya Town with no evident high-risk behaviour contributed peripheral blood mononuclear cells for this study. Nine virtually full-length-genome-sequences were amplified from this DNA and phylogenetically analysed.
Out of the nine samples, two were subtype A (22%), two were subtype C (22%) and five were recombinants (56%): four A/C recombinants and one C/D recombinant. None of the recombinants were related to each other; all of them had different mosaic structures. Most of the genome in the recombinants was subtype C.
A high proportion of unrelated intersubtype recombinants, none of them apparently spreading in the population, may be present in southwest Tanzania.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11504977</pmid><doi>10.1097/00002030-200108170-00002</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0269-9370 |
| ispartof | AIDS (London), 2001-08, Vol.15 (12), p.1461-1470 |
| issn | 0269-9370 1473-5571 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult AIDS/HIV Biological and medical sciences Female Genome, Viral HIV Infections - virology HIV-1 - classification HIV-1 - genetics Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Male Medical sciences Molecular Sequence Data Phylogeny Recombination, Genetic Sequence Analysis, DNA Tanzania Tropical medicine Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | High proportion of unrelated HIV-1 intersubtype recombinants in the Mbeya region of southwest Tanzania |
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