Tau protein is a potential biological marker for normal pressure hydrocephalus
A biological marker for normal pressure hydrocephalus (NPH) is beneficial for evaluation of its severity and of indications for shunt operation. Tau protein was initially considered as a biological marker in cerebrospinal fluid (CSF) from Alzheimer’s patients. Recently, it has been demonstrated that...
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| Veröffentlicht in: | Psychiatry and clinical neurosciences 2000-04, Vol.54 (2), p.199-202 |
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| creator | Kudo, Takashi Mima, Tatsuo Hashimoto, Ryouta Nakao, Kazuhisa Morihara, Takashi Tanimukai, Hitoshi Tsujio, Ichiro Koike, Yuko Tagami, Shinji Mori, Hiroshi Nakamura, Yu Tanaka, Toshihisa Mori, Koreaki Takeda, Masatoshi |
| description | A biological marker for normal pressure hydrocephalus (NPH) is beneficial for evaluation of its severity and of indications for shunt operation. Tau protein was initially considered as a biological marker in cerebrospinal fluid (CSF) from Alzheimer’s patients. Recently, it has been demonstrated that degeneration in the brain causes elevation of tau in CSF. Therefore, the tau level in CSF from NPH patients was evaluated. Tau levels in CSF from NPH patients were significantly higher than that in controls. The tau levels were correlated with the severity of dementia, urinary incontinence, and gait disturbance in NPH. These results suggest that CSF tau may be useful as a biological marker for NPH to determine the level of neuronal degeneration. |
| doi_str_mv | 10.1046/j.1440-1819.2000.00658.x |
| format | Article |
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Tau protein was initially considered as a biological marker in cerebrospinal fluid (CSF) from Alzheimer’s patients. Recently, it has been demonstrated that degeneration in the brain causes elevation of tau in CSF. Therefore, the tau level in CSF from NPH patients was evaluated. Tau levels in CSF from NPH patients were significantly higher than that in controls. The tau levels were correlated with the severity of dementia, urinary incontinence, and gait disturbance in NPH. These results suggest that CSF tau may be useful as a biological marker for NPH to determine the level of neuronal degeneration.</description><identifier>ISSN: 1323-1316</identifier><identifier>EISSN: 1440-1819</identifier><identifier>DOI: 10.1046/j.1440-1819.2000.00658.x</identifier><identifier>PMID: 10803815</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Science Pty</publisher><subject>Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Alzheimer Disease - cerebrospinal fluid ; Alzheimer Disease - diagnosis ; Alzheimer’s disease ; Biological and medical sciences ; biological marker ; Biomarkers - cerebrospinal fluid ; cerebrospinal fluid ; Dementia - cerebrospinal fluid ; Dementia - diagnosis ; Female ; Humans ; Hydrocephalus, Normal Pressure - cerebrospinal fluid ; Hydrocephalus, Normal Pressure - diagnosis ; Hydrocephalus, Normal Pressure - etiology ; Male ; Medical sciences ; Middle Aged ; neurodegeneration ; normal pressure hydrocephalus ; Organic mental disorders. Neuropsychology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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Tau protein was initially considered as a biological marker in cerebrospinal fluid (CSF) from Alzheimer’s patients. Recently, it has been demonstrated that degeneration in the brain causes elevation of tau in CSF. Therefore, the tau level in CSF from NPH patients was evaluated. Tau levels in CSF from NPH patients were significantly higher than that in controls. The tau levels were correlated with the severity of dementia, urinary incontinence, and gait disturbance in NPH. These results suggest that CSF tau may be useful as a biological marker for NPH to determine the level of neuronal degeneration.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - cerebrospinal fluid</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer’s disease</subject><subject>Biological and medical sciences</subject><subject>biological marker</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>cerebrospinal fluid</subject><subject>Dementia - cerebrospinal fluid</subject><subject>Dementia - diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocephalus, Normal Pressure - cerebrospinal fluid</subject><subject>Hydrocephalus, Normal Pressure - diagnosis</subject><subject>Hydrocephalus, Normal Pressure - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>neurodegeneration</subject><subject>normal pressure hydrocephalus</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Sensitivity and Specificity</subject><subject>tau</subject><subject>tau Proteins - cerebrospinal fluid</subject><issn>1323-1316</issn><issn>1440-1819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P4zAQhi3Eiu-_gHxA3BJm4tg4EhdU8bFSxe6BPVu2a1OXNAl2I-i_X5dWLMc9-ZX9zIznIYQilAi1uFqUWNdQoMSmrACgBBBclh975OjrYT9nVrECGYpDcpzSIoOMCTwghwgSmER-RJ6e9UiH2K9c6GhIVNMh524VdEtN6Nv-Jdgclzq-ukh9H2nXx2W-GaJLaYyOztez2Fs3zHU7plPyw-s2ubPdeUL-3N89Tx6L6a-Hn5PbaWHrBmThHPfCas944w1DrK-9r2qUtfDGcMNtbQ1zsmGVAG05N4ZVcgZGCulm0CA7IZfbvvnrb6NLK7UMybq21Z3rx6SuERoQKDMot6CNfUrReTXEkLdZKwS1cakWaqNMbZSpjUv16VJ95NLz3YzRLN3sW-FWXgYudoBOWZKPurMh_eNYw2XFMnazxd5D69b_PV_9njzlwP4C2sKPow</recordid><startdate>200004</startdate><enddate>200004</enddate><creator>Kudo, Takashi</creator><creator>Mima, Tatsuo</creator><creator>Hashimoto, Ryouta</creator><creator>Nakao, Kazuhisa</creator><creator>Morihara, Takashi</creator><creator>Tanimukai, Hitoshi</creator><creator>Tsujio, Ichiro</creator><creator>Koike, Yuko</creator><creator>Tagami, Shinji</creator><creator>Mori, Hiroshi</creator><creator>Nakamura, Yu</creator><creator>Tanaka, Toshihisa</creator><creator>Mori, Koreaki</creator><creator>Takeda, Masatoshi</creator><general>Blackwell Science Pty</general><general>Blackwell Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200004</creationdate><title>Tau protein is a potential biological marker for normal pressure hydrocephalus</title><author>Kudo, Takashi ; Mima, Tatsuo ; Hashimoto, Ryouta ; Nakao, Kazuhisa ; Morihara, Takashi ; Tanimukai, Hitoshi ; Tsujio, Ichiro ; Koike, Yuko ; Tagami, Shinji ; Mori, Hiroshi ; Nakamura, Yu ; Tanaka, Toshihisa ; Mori, Koreaki ; Takeda, Masatoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4908-ee5f6caf359fb31147ff241846fbb5b5c4cb3e893260ac55bb328d0b868ed0913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - cerebrospinal fluid</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer’s disease</topic><topic>Biological and medical sciences</topic><topic>biological marker</topic><topic>Biomarkers - cerebrospinal fluid</topic><topic>cerebrospinal fluid</topic><topic>Dementia - cerebrospinal fluid</topic><topic>Dementia - diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocephalus, Normal Pressure - cerebrospinal fluid</topic><topic>Hydrocephalus, Normal Pressure - diagnosis</topic><topic>Hydrocephalus, Normal Pressure - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>neurodegeneration</topic><topic>normal pressure hydrocephalus</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Sensitivity and Specificity</topic><topic>tau</topic><topic>tau Proteins - cerebrospinal fluid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kudo, Takashi</creatorcontrib><creatorcontrib>Mima, Tatsuo</creatorcontrib><creatorcontrib>Hashimoto, Ryouta</creatorcontrib><creatorcontrib>Nakao, Kazuhisa</creatorcontrib><creatorcontrib>Morihara, Takashi</creatorcontrib><creatorcontrib>Tanimukai, Hitoshi</creatorcontrib><creatorcontrib>Tsujio, Ichiro</creatorcontrib><creatorcontrib>Koike, Yuko</creatorcontrib><creatorcontrib>Tagami, Shinji</creatorcontrib><creatorcontrib>Mori, Hiroshi</creatorcontrib><creatorcontrib>Nakamura, Yu</creatorcontrib><creatorcontrib>Tanaka, Toshihisa</creatorcontrib><creatorcontrib>Mori, Koreaki</creatorcontrib><creatorcontrib>Takeda, Masatoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry and clinical neurosciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kudo, Takashi</au><au>Mima, Tatsuo</au><au>Hashimoto, Ryouta</au><au>Nakao, Kazuhisa</au><au>Morihara, Takashi</au><au>Tanimukai, Hitoshi</au><au>Tsujio, Ichiro</au><au>Koike, Yuko</au><au>Tagami, Shinji</au><au>Mori, Hiroshi</au><au>Nakamura, Yu</au><au>Tanaka, Toshihisa</au><au>Mori, Koreaki</au><au>Takeda, Masatoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tau protein is a potential biological marker for normal pressure hydrocephalus</atitle><jtitle>Psychiatry and clinical neurosciences</jtitle><addtitle>Psychiatry Clin Neurosci</addtitle><date>2000-04</date><risdate>2000</risdate><volume>54</volume><issue>2</issue><spage>199</spage><epage>202</epage><pages>199-202</pages><issn>1323-1316</issn><eissn>1440-1819</eissn><abstract>A biological marker for normal pressure hydrocephalus (NPH) is beneficial for evaluation of its severity and of indications for shunt operation. Tau protein was initially considered as a biological marker in cerebrospinal fluid (CSF) from Alzheimer’s patients. Recently, it has been demonstrated that degeneration in the brain causes elevation of tau in CSF. Therefore, the tau level in CSF from NPH patients was evaluated. Tau levels in CSF from NPH patients were significantly higher than that in controls. The tau levels were correlated with the severity of dementia, urinary incontinence, and gait disturbance in NPH. These results suggest that CSF tau may be useful as a biological marker for NPH to determine the level of neuronal degeneration.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Science Pty</pub><pmid>10803815</pmid><doi>10.1046/j.1440-1819.2000.00658.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult and adolescent clinical studies Aged Aged, 80 and over Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - diagnosis Alzheimer’s disease Biological and medical sciences biological marker Biomarkers - cerebrospinal fluid cerebrospinal fluid Dementia - cerebrospinal fluid Dementia - diagnosis Female Humans Hydrocephalus, Normal Pressure - cerebrospinal fluid Hydrocephalus, Normal Pressure - diagnosis Hydrocephalus, Normal Pressure - etiology Male Medical sciences Middle Aged neurodegeneration normal pressure hydrocephalus Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Sensitivity and Specificity tau tau Proteins - cerebrospinal fluid |
| title | Tau protein is a potential biological marker for normal pressure hydrocephalus |
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