Serological methods for diagnosis of Helicobacter pylori infection and monitoring of eradication therapy
Several methods can be used to diagnose Helicobacter pylori infection. Invasive methods include detection of the bacterium in gastric biopsy specimens by culture, immunohistochemistry, rapid urease tests, or the polymerase chain reaction. Noninvasive or less invasive detection methods include the ur...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2000-03, Vol.19 (3), p.164-173 |
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| description | Several methods can be used to diagnose Helicobacter pylori infection. Invasive methods include detection of the bacterium in gastric biopsy specimens by culture, immunohistochemistry, rapid urease tests, or the polymerase chain reaction. Noninvasive or less invasive detection methods include the urea breath test and serological methods. The urea breath test is based on the detection of 13CO2 or 14CO2 in breath, produced by bacterial urease in the stomach after labelled urea is swallowed. Serological methods are based on the detection of Helicobacter pylori-specific antibodies in serum, saliva, or urine. In this review, the performance and diagnostic value of several serological methods, such as enzyme immunoassay, rapid office-based assays, and Western blot, will be discussed in relation to biopsy-based methods and the urea breath test. In addition, the value of serological assays for monitoring eradication of Helicobacter pylori infection following treatment will be discussed. The diagnostic performance of properly evaluated serological assays is comparable to that of biopsy-based methods and the urea breath test. To monitor eradication of Helicobacter pylori infection following therapy, quantitative enzyme immunoassays can be used, especially in patients with high pretreatment antibody titres. |
| doi_str_mv | 10.1007/s100960050454 |
| format | Article |
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In addition, the value of serological assays for monitoring eradication of Helicobacter pylori infection following treatment will be discussed. The diagnostic performance of properly evaluated serological assays is comparable to that of biopsy-based methods and the urea breath test. To monitor eradication of Helicobacter pylori infection following therapy, quantitative enzyme immunoassays can be used, especially in patients with high pretreatment antibody titres.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s100960050454</identifier><identifier>PMID: 10795588</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Antibodies, Bacterial - analysis ; Antibodies, Bacterial - blood ; Antibodies, Bacterial - urine ; Antigens, Bacterial - immunology ; Biological and medical sciences ; Biopsy ; Breath tests ; Carbon dioxide ; Enzymes ; Genes ; Genomes ; Helicobacter Infections - diagnosis ; Helicobacter Infections - drug therapy ; Helicobacter Infections - microbiology ; Helicobacter pylori ; Helicobacter pylori - genetics ; Helicobacter pylori - immunology ; Humans ; Immunoassays ; Infections ; Investigative techniques, diagnostic techniques (general aspects) ; Medical laboratories ; Medical sciences ; Miscellaneous. Technology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Polymerase chain reaction ; Serologic Tests ; Serology ; Stomach ; Ulcers ; Urea ; urea breath test ; Virulence</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2000-03, Vol.19 (3), p.164-173</ispartof><rights>2000 INIST-CNRS</rights><rights>Springer-Verlag Berlin Heidelberg 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-5d6da4e40c29aa1183e65029659f43b9e4c63b1eadf5e23f52413227aab570483</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1353888$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10795588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HERBRINK, P</creatorcontrib><creatorcontrib>VAN DOOM, L. J</creatorcontrib><title>Serological methods for diagnosis of Helicobacter pylori infection and monitoring of eradication therapy</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Several methods can be used to diagnose Helicobacter pylori infection. Invasive methods include detection of the bacterium in gastric biopsy specimens by culture, immunohistochemistry, rapid urease tests, or the polymerase chain reaction. Noninvasive or less invasive detection methods include the urea breath test and serological methods. The urea breath test is based on the detection of 13CO2 or 14CO2 in breath, produced by bacterial urease in the stomach after labelled urea is swallowed. Serological methods are based on the detection of Helicobacter pylori-specific antibodies in serum, saliva, or urine. In this review, the performance and diagnostic value of several serological methods, such as enzyme immunoassay, rapid office-based assays, and Western blot, will be discussed in relation to biopsy-based methods and the urea breath test. In addition, the value of serological assays for monitoring eradication of Helicobacter pylori infection following treatment will be discussed. The diagnostic performance of properly evaluated serological assays is comparable to that of biopsy-based methods and the urea breath test. To monitor eradication of Helicobacter pylori infection following therapy, quantitative enzyme immunoassays can be used, especially in patients with high pretreatment antibody titres.</description><subject>Antibodies, Bacterial - analysis</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antibodies, Bacterial - urine</subject><subject>Antigens, Bacterial - immunology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Breath tests</subject><subject>Carbon dioxide</subject><subject>Enzymes</subject><subject>Genes</subject><subject>Genomes</subject><subject>Helicobacter Infections - diagnosis</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter pylori</subject><subject>Helicobacter pylori - genetics</subject><subject>Helicobacter pylori - immunology</subject><subject>Humans</subject><subject>Immunoassays</subject><subject>Infections</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical laboratories</subject><subject>Medical sciences</subject><subject>Miscellaneous. Technology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Polymerase chain reaction</subject><subject>Serologic Tests</subject><subject>Serology</subject><subject>Stomach</subject><subject>Ulcers</subject><subject>Urea</subject><subject>urea breath test</subject><subject>Virulence</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0c1rHCEYBnApLc0m6THXIqXkNu3r-DUeS2ibQCCHNufBcV53DTO61dnD_vcx3YUmveSi6PvjQXkIuWDwhQHor6WuRgFIEFK8ISsmuGwE1_wtWYHhojG65SfktJQHqL7T-j05YaCNlF23IptfmNOU1sHZic64bNJYqE-ZjsGuYyqh0OTpNU7BpcG6BTPd7qeUAw3Ro1tCitTGkc4phqVex_WTx2zHmvh3umzqabs_J--8nQp-OO5n5P7H999X183t3c-bq2-3jeNaLY0c1WgFCnCtsZaxjqOS0BoljRd8MCic4gNDO3qJLfeyFYy3rbZ2kBpEx8_I5SF3m9OfHZaln0NxOE02YtqVXjMwwFvzKmRa8k4zVuGn_-BD2uVYP9HXOTClQFXUHJDLqZSMvt_mMNu87xn0T0X1L4qq_uMxdDfMOD7Th2Yq-HwEttRufLbRhfLP8fq6yh4Beymagw</recordid><startdate>20000301</startdate><enddate>20000301</enddate><creator>HERBRINK, P</creator><creator>VAN DOOM, L. 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J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-5d6da4e40c29aa1183e65029659f43b9e4c63b1eadf5e23f52413227aab570483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Antibodies, Bacterial - analysis</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antibodies, Bacterial - urine</topic><topic>Antigens, Bacterial - immunology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Breath tests</topic><topic>Carbon dioxide</topic><topic>Enzymes</topic><topic>Genes</topic><topic>Genomes</topic><topic>Helicobacter Infections - diagnosis</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter pylori</topic><topic>Helicobacter pylori - genetics</topic><topic>Helicobacter pylori - immunology</topic><topic>Humans</topic><topic>Immunoassays</topic><topic>Infections</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Medical laboratories</topic><topic>Medical sciences</topic><topic>Miscellaneous. Technology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Polymerase chain reaction</topic><topic>Serologic Tests</topic><topic>Serology</topic><topic>Stomach</topic><topic>Ulcers</topic><topic>Urea</topic><topic>urea breath test</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HERBRINK, P</creatorcontrib><creatorcontrib>VAN DOOM, L. 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The urea breath test is based on the detection of 13CO2 or 14CO2 in breath, produced by bacterial urease in the stomach after labelled urea is swallowed. Serological methods are based on the detection of Helicobacter pylori-specific antibodies in serum, saliva, or urine. In this review, the performance and diagnostic value of several serological methods, such as enzyme immunoassay, rapid office-based assays, and Western blot, will be discussed in relation to biopsy-based methods and the urea breath test. In addition, the value of serological assays for monitoring eradication of Helicobacter pylori infection following treatment will be discussed. The diagnostic performance of properly evaluated serological assays is comparable to that of biopsy-based methods and the urea breath test. To monitor eradication of Helicobacter pylori infection following therapy, quantitative enzyme immunoassays can be used, especially in patients with high pretreatment antibody titres.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>10795588</pmid><doi>10.1007/s100960050454</doi><tpages>10</tpages></addata></record> |
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| subjects | Antibodies, Bacterial - analysis Antibodies, Bacterial - blood Antibodies, Bacterial - urine Antigens, Bacterial - immunology Biological and medical sciences Biopsy Breath tests Carbon dioxide Enzymes Genes Genomes Helicobacter Infections - diagnosis Helicobacter Infections - drug therapy Helicobacter Infections - microbiology Helicobacter pylori Helicobacter pylori - genetics Helicobacter pylori - immunology Humans Immunoassays Infections Investigative techniques, diagnostic techniques (general aspects) Medical laboratories Medical sciences Miscellaneous. Technology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase chain reaction Serologic Tests Serology Stomach Ulcers Urea urea breath test Virulence |
| title | Serological methods for diagnosis of Helicobacter pylori infection and monitoring of eradication therapy |
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