The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse
The quantal release of glutamate depends on its transport into synaptic vesicles. Recent work has shown that a protein previously implicated in the uptake of inorganic phosphate across the plasma membrane catalyzes glutamate uptake by synaptic vesicles. However, only a subset of glutamate neurons ex...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2001-08, Vol.31 (2), p.247-260 |
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| container_title | Neuron (Cambridge, Mass.) |
| container_volume | 31 |
| creator | Fremeau, Robert T Troyer, Matthew D Pahner, Ingrid Nygaard, Gro Owren Tran, Cindy H Reimer, Richard J Bellocchio, Elizabeth E Fortin, Doris Storm-Mathisen, Jon Edwards, Robert H |
| description | The quantal release of glutamate depends on its transport into synaptic vesicles. Recent work has shown that a protein previously implicated in the uptake of inorganic phosphate across the plasma membrane catalyzes glutamate uptake by synaptic vesicles. However, only a subset of glutamate neurons expresses this vesicular glutamate transporter (VGLUT1). We now report that excitatory neurons lacking VGLUT1 express a closely related protein that has also been implicated in phosphate transport. Like VGLUT1, this protein localizes to synaptic vesicles and functions as a vesicular glutamate transporter (VGLUT2). The complementary expression of VGLUT1 and 2 defines two distinct classes of excitatory synapse. |
| doi_str_mv | 10.1016/S0896-6273(01)00344-0 |
| format | Article |
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Recent work has shown that a protein previously implicated in the uptake of inorganic phosphate across the plasma membrane catalyzes glutamate uptake by synaptic vesicles. However, only a subset of glutamate neurons expresses this vesicular glutamate transporter (VGLUT1). We now report that excitatory neurons lacking VGLUT1 express a closely related protein that has also been implicated in phosphate transport. Like VGLUT1, this protein localizes to synaptic vesicles and functions as a vesicular glutamate transporter (VGLUT2). 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| source | MEDLINE; Cell Press Free Archives; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Amino Acid Sequence Animals Brain Chemistry Carrier Proteins - analysis Carrier Proteins - chemistry Carrier Proteins - genetics Gene Expression Glutamic Acid - metabolism Immunohistochemistry In Situ Hybridization Membrane Transport Proteins Mice Molecular Sequence Data Neurons - chemistry Neurons - ultrastructure PC12 Cells Phosphates - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - analysis Sequence Alignment Synapses - chemistry Synapses - physiology Synaptic Vesicles - chemistry Synaptic Vesicles - metabolism Tissue Distribution Vesicular Glutamate Transport Protein 1 Vesicular Glutamate Transport Protein 2 Vesicular Transport Proteins |
| title | The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse |
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