A multiplex PCR-based DNA assay for the detection of paraoxonase gene cluster polymorphisms

Paraoxonase (PON) is a high-density lipoprotein (HDL) associated protein which is supposed to protect low-density lipoprotein (LDL) against oxidation and to play a role in the development of atherosclerosis. Interindividual variability in serum PON activity is attributable to common variants in comp...

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Veröffentlicht in:	Atherosclerosis 2001-09, Vol.158 (1), p.35-40
Hauptverfasser:	Motti, Corradino, Dessı̀, Mariarita, Gnasso, Agostino, Irace, Concetta, Indigeno, Paola, Angelucci, Clotilde B., Bernardini, Sergio, Fucci, Giorgio, Federici, Giorgio, Cortese, Claudio
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Arteriosclerosis - enzymology Arteriosclerosis - genetics Aryldialkylphosphatase Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Chromosomes, Human, Pair 7 Coronary heart disease Esterases - blood Esterases - genetics Female Genetic Predisposition to Disease Genotype High-density lipoprotein Humans Male Medical sciences Middle Aged Multiplex PCR Paraoxonase Polymerase chain reaction Polymerase Chain Reaction - methods Polymorphism Polymorphism, Genetic Risk Factors
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