p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase

Tryptophan hydroxylase (TPH) is the initial and rate-limiting enzyme in serotonin biosynthesis. The enzyme activity is dependent on molecular oxygen, a tetrahydropterin cosubstrate, and ferrous iron. The present study demonstrates that TPH is inhibited by a novel compound, p-ethynylphenylalanine (pE...

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Veröffentlicht in:	Journal of neurochemistry 2000-05, Vol.74 (5), p.2067-2073
Hauptverfasser:	Stokes, A H, Xu, Y, Daunais, J A, Tamir, H, Gershon, M D, Butkerait, P, Kayser, B, Altman, J, Beck, W, Vrana, K E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - pharmacology Animals Brain - enzymology Brain - metabolism Enzyme Inhibitors - pharmacology Fenclonine - pharmacology Humans Hydroxyindoleacetic Acid - antagonists & inhibitors Hydroxyindoleacetic Acid - metabolism Infant, Newborn Kinetics Male p-Ethynylphenylalanine Rabbits Rats Rats, Inbred F344 Rats, Sprague-Dawley Recombinant Proteins - antagonists & inhibitors Serotonin - metabolism Serotonin Antagonists - pharmacology Tryptophan Hydroxylase - antagonists & inhibitors Tyrosine 3-Monooxygenase - antagonists & inhibitors
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