Gene Response of Human Skin Fibroblasts to Urokinase-and Tissue-Type Plasminogen Activators

Abstract In a previous work we have reported evidences on the mitogenic activity of urokinase-type and tissue-type plasminogen activator (u-PA, t-PA) on serum-deprived human dermal fibroblasts. In this work we have studied the transcription-dependent changes of some cell-cycle related genes associat...

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Veröffentlicht in:	Growth factors (Chur, Switzerland) Switzerland), 2000, Vol.17 (4), p.249-268
Hauptverfasser:	Copeta, Alessandro, Tavian, Daniela, Marchina, Eleonora, Petro, Giuseppina De, Barlati, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	cell cycle related genes Cell Division Cell Line cell proliferation Culture Media, Serum-Free Cyclin-Dependent Kinase Inhibitor p21 Cyclins - genetics Cyclins - metabolism DNA - biosynthesis Enzyme Inhibitors - pharmacology Female Fibroblasts - cytology Fibroblasts - metabolism Fluorescent Antibody Technique Gene Expression Regulation, Enzymologic Genistein - pharmacology growth factor Humans Male MAP Kinase Kinase 1 Mitogen-Activated Protein Kinase Kinases - metabolism Plasminogen activators protein kinase C Protein Kinase C - genetics protein tyrosine kinases Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - genetics Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Proto-Oncogene Proteins c-jun - genetics Proto-Oncogene Proteins c-jun - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Skin - cytology Tissue Plasminogen Activator - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Urokinase-Type Plasminogen Activator - metabolism
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