G551D CF mice display an abnormal host response and have impaired clearance of Pseudomonas lung disease

Institute for Molecular Biosciences, University of Queensland, St. Lucia, Queensland 4072, Australia Several cystic fibrosis (CF) mouse models demonstrate an increased susceptibility to Pseudomonas aeruginosa lung infection, characterized by excessive inflammation and high rates of mortality. Here w...

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Veröffentlicht in:	American journal of physiology. Lung cellular and molecular physiology 2001-09, Vol.281 (3), p.740-L747
Hauptverfasser:	McMorran, B. J, Palmer, J. S, Lunn, D. P, Oceandy, D, Costelloe, E. O, Thomas, G. R, Hume, D. A, Wainwright, B. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Body Weight Bronchoalveolar Lavage Fluid - chemistry Chronic Disease Colony Count, Microbial Cystic Fibrosis - genetics Cystic Fibrosis - microbiology Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cytokines - metabolism Homozygote Inflammation Mediators - metabolism Lung - microbiology Lung Diseases - metabolism Lung Diseases - microbiology Lung Diseases - pathology Mice Mice, Mutant Strains Mutation - physiology Pneumonia, Bacterial - microbiology Pneumonia, Bacterial - pathology Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - complications Pseudomonas Infections - metabolism Pseudomonas Infections - microbiology Pseudomonas Infections - pathology Reference Values
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