Relationship of Brain Ethanol Metabolism to the Hypnotic Effect of Ethanol. I: Studies in Outbred Animals
Background : This study was designed to investigate the relationship between the ethanol‐oxidizing capacity of the brain, accumulation of acetaldehyde, and ethanol‐induced hypnosis in animals in vivo. Methods: Randomly outbred albino rats were treated with ethanol, and the duration of ethanol‐induce...
Gespeichert in:
| Veröffentlicht in: | Alcoholism, clinical and experimental research clinical and experimental research, 2001-07, Vol.25 (7), p.976-981 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 981 |
|---|---|
| container_issue | 7 |
| container_start_page | 976 |
| container_title | Alcoholism, clinical and experimental research |
| container_volume | 25 |
| creator | Zimatkin, Sergey M. Liopo, Anton V. Slychenkov, V. S. Deitrich, Richard A. |
| description | Background : This study was designed to investigate the relationship between the ethanol‐oxidizing capacity of the brain, accumulation of acetaldehyde, and ethanol‐induced hypnosis in animals in vivo.
Methods: Randomly outbred albino rats were treated with ethanol, and the duration of ethanol‐induced loss of the righting response (sleep time) was measured. They were killed 2 weeks later (without further in vivo administration of ethanol), and brain homogenates were prepared to measure the accumulation of acetaldehyde from ethanol added in vitro. In a similar way, we determined the sleep time and, 5 days later, the rates of acetaldehyde accumulation in brains of heterogeneous mice.
Results: Significant correlations between the duration of ethanol‐induced sleep and acetaldehyde accumulation in vitro were found. The Km value of the process of acetaldehyde accumulation was lower in long‐sleeping, as compared with short‐sleeping, rats. A similar result was also obtained in genetically heterogeneous mice. Animals with a longer duration of ethanol‐induced sleep had a higher level of the accumulation of ethanol‐derived acetaldehyde in brain homogenates, as compared with the short‐sleeping mice. Rats and mice with the intermediate duration of ethanol‐induced sleep had an intermediate value of acetaldehyde accumulation in brain homogenates. There was no correlation between brain catalase activity and ethanol‐induced loss of the righting response in either the rats or the mice.
Conclusions: This study is a direct demonstration of the positive correlation between ethanol‐derived acetaldehyde accumulation in vitro in the brain and a central (behavioral) effect of alcohol in outbred rats and mice in vivo. |
| doi_str_mv | 10.1111/j.1530-0277.2001.tb02305.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71087953</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71087953</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4386-9b29b7a81074163ae7b1a735634a336f4686dbc5b36cd33ced5c67dc154af4b33</originalsourceid><addsrcrecordid>eNqVkF1v0zAUhi0EYt3gLyALIe4S7Di2k92gUnUfaGOwgZC4sWzHUV3SuLMdrf33OGq0cTvfnAs_73uOHgDeY5Tj9D6tc0wJylDBeV4ghPOoUEEQzXcvwOzx6yWYIVzSjCFUHYHjENYIobJi7DU4wpgiigo8A_bWdDJa14eV3ULXwi9e2h4u40r2roPXJkrlOhs2MDoYVwZe7Le9i1bDZdsaHcfIBOfw8hTexaGxJsDUcTNE5U0D573dyC68Aa_aNMzbaZ6AX2fLn4uL7Orm_HIxv8p0SSqW1aqoFZcVRrzEjEjDFZacUEZKSQhrS1axRmmqCNMNIdo0VDPeaExL2ZaKkBPw8dC79e5-MCGKjQ3adJ3sjRuC4BhVvKYjeHoAtXcheNOKrU-X-r3ASIyixVqMNsVoU4yixSRa7FL43bRlUBvTPEUnswn4MAEyaNm1Xvbahv9WsDpxCft8wB5sZ_bPuEDMF8vbmrPUkB0abIhm99gg_V_BOOFU_P52Ln6wr9UfdnctvpN_B2OpAQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71087953</pqid></control><display><type>article</type><title>Relationship of Brain Ethanol Metabolism to the Hypnotic Effect of Ethanol. I: Studies in Outbred Animals</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><source>Access via Wiley Online Library</source><creator>Zimatkin, Sergey M. ; Liopo, Anton V. ; Slychenkov, V. S. ; Deitrich, Richard A.</creator><creatorcontrib>Zimatkin, Sergey M. ; Liopo, Anton V. ; Slychenkov, V. S. ; Deitrich, Richard A.</creatorcontrib><description>Background : This study was designed to investigate the relationship between the ethanol‐oxidizing capacity of the brain, accumulation of acetaldehyde, and ethanol‐induced hypnosis in animals in vivo.
Methods: Randomly outbred albino rats were treated with ethanol, and the duration of ethanol‐induced loss of the righting response (sleep time) was measured. They were killed 2 weeks later (without further in vivo administration of ethanol), and brain homogenates were prepared to measure the accumulation of acetaldehyde from ethanol added in vitro. In a similar way, we determined the sleep time and, 5 days later, the rates of acetaldehyde accumulation in brains of heterogeneous mice.
Results: Significant correlations between the duration of ethanol‐induced sleep and acetaldehyde accumulation in vitro were found. The Km value of the process of acetaldehyde accumulation was lower in long‐sleeping, as compared with short‐sleeping, rats. A similar result was also obtained in genetically heterogeneous mice. Animals with a longer duration of ethanol‐induced sleep had a higher level of the accumulation of ethanol‐derived acetaldehyde in brain homogenates, as compared with the short‐sleeping mice. Rats and mice with the intermediate duration of ethanol‐induced sleep had an intermediate value of acetaldehyde accumulation in brain homogenates. There was no correlation between brain catalase activity and ethanol‐induced loss of the righting response in either the rats or the mice.
Conclusions: This study is a direct demonstration of the positive correlation between ethanol‐derived acetaldehyde accumulation in vitro in the brain and a central (behavioral) effect of alcohol in outbred rats and mice in vivo.</description><identifier>ISSN: 0145-6008</identifier><identifier>EISSN: 1530-0277</identifier><identifier>DOI: 10.1111/j.1530-0277.2001.tb02305.x</identifier><identifier>PMID: 11505021</identifier><identifier>CODEN: ACRSDM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Acetaldehyde ; Acetaldehyde - metabolism ; Alcohol Sensitivity ; Alcoholism and acute alcohol poisoning ; Animals ; Behavior ; Biological and medical sciences ; Brain - drug effects ; Brain - enzymology ; Brain - metabolism ; Brain Ethanol Metabolism ; Catalase - metabolism ; Central Nervous System Depressants - metabolism ; Central Nervous System Depressants - pharmacology ; Ethanol - metabolism ; Ethanol - pharmacology ; Hypnotics and Sedatives - pharmacology ; Hypnotics. Sedatives ; Kinetics ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Sleep - drug effects ; Sleep - genetics ; Time Factors ; Toxicology</subject><ispartof>Alcoholism, clinical and experimental research, 2001-07, Vol.25 (7), p.976-981</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4386-9b29b7a81074163ae7b1a735634a336f4686dbc5b36cd33ced5c67dc154af4b33</citedby><cites>FETCH-LOGICAL-c4386-9b29b7a81074163ae7b1a735634a336f4686dbc5b36cd33ced5c67dc154af4b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1530-0277.2001.tb02305.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1530-0277.2001.tb02305.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1069502$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11505021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zimatkin, Sergey M.</creatorcontrib><creatorcontrib>Liopo, Anton V.</creatorcontrib><creatorcontrib>Slychenkov, V. S.</creatorcontrib><creatorcontrib>Deitrich, Richard A.</creatorcontrib><title>Relationship of Brain Ethanol Metabolism to the Hypnotic Effect of Ethanol. I: Studies in Outbred Animals</title><title>Alcoholism, clinical and experimental research</title><addtitle>Alcohol Clin Exp Res</addtitle><description>Background : This study was designed to investigate the relationship between the ethanol‐oxidizing capacity of the brain, accumulation of acetaldehyde, and ethanol‐induced hypnosis in animals in vivo.
Methods: Randomly outbred albino rats were treated with ethanol, and the duration of ethanol‐induced loss of the righting response (sleep time) was measured. They were killed 2 weeks later (without further in vivo administration of ethanol), and brain homogenates were prepared to measure the accumulation of acetaldehyde from ethanol added in vitro. In a similar way, we determined the sleep time and, 5 days later, the rates of acetaldehyde accumulation in brains of heterogeneous mice.
Results: Significant correlations between the duration of ethanol‐induced sleep and acetaldehyde accumulation in vitro were found. The Km value of the process of acetaldehyde accumulation was lower in long‐sleeping, as compared with short‐sleeping, rats. A similar result was also obtained in genetically heterogeneous mice. Animals with a longer duration of ethanol‐induced sleep had a higher level of the accumulation of ethanol‐derived acetaldehyde in brain homogenates, as compared with the short‐sleeping mice. Rats and mice with the intermediate duration of ethanol‐induced sleep had an intermediate value of acetaldehyde accumulation in brain homogenates. There was no correlation between brain catalase activity and ethanol‐induced loss of the righting response in either the rats or the mice.
Conclusions: This study is a direct demonstration of the positive correlation between ethanol‐derived acetaldehyde accumulation in vitro in the brain and a central (behavioral) effect of alcohol in outbred rats and mice in vivo.</description><subject>Acetaldehyde</subject><subject>Acetaldehyde - metabolism</subject><subject>Alcohol Sensitivity</subject><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Behavior</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - enzymology</subject><subject>Brain - metabolism</subject><subject>Brain Ethanol Metabolism</subject><subject>Catalase - metabolism</subject><subject>Central Nervous System Depressants - metabolism</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Ethanol - metabolism</subject><subject>Ethanol - pharmacology</subject><subject>Hypnotics and Sedatives - pharmacology</subject><subject>Hypnotics. Sedatives</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Sleep - drug effects</subject><subject>Sleep - genetics</subject><subject>Time Factors</subject><subject>Toxicology</subject><issn>0145-6008</issn><issn>1530-0277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1v0zAUhi0EYt3gLyALIe4S7Di2k92gUnUfaGOwgZC4sWzHUV3SuLMdrf33OGq0cTvfnAs_73uOHgDeY5Tj9D6tc0wJylDBeV4ghPOoUEEQzXcvwOzx6yWYIVzSjCFUHYHjENYIobJi7DU4wpgiigo8A_bWdDJa14eV3ULXwi9e2h4u40r2roPXJkrlOhs2MDoYVwZe7Le9i1bDZdsaHcfIBOfw8hTexaGxJsDUcTNE5U0D573dyC68Aa_aNMzbaZ6AX2fLn4uL7Orm_HIxv8p0SSqW1aqoFZcVRrzEjEjDFZacUEZKSQhrS1axRmmqCNMNIdo0VDPeaExL2ZaKkBPw8dC79e5-MCGKjQ3adJ3sjRuC4BhVvKYjeHoAtXcheNOKrU-X-r3ASIyixVqMNsVoU4yixSRa7FL43bRlUBvTPEUnswn4MAEyaNm1Xvbahv9WsDpxCft8wB5sZ_bPuEDMF8vbmrPUkB0abIhm99gg_V_BOOFU_P52Ln6wr9UfdnctvpN_B2OpAQ</recordid><startdate>200107</startdate><enddate>200107</enddate><creator>Zimatkin, Sergey M.</creator><creator>Liopo, Anton V.</creator><creator>Slychenkov, V. S.</creator><creator>Deitrich, Richard A.</creator><general>Blackwell Publishing Ltd</general><general>Lippincott Williams & Wilkins</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200107</creationdate><title>Relationship of Brain Ethanol Metabolism to the Hypnotic Effect of Ethanol. I: Studies in Outbred Animals</title><author>Zimatkin, Sergey M. ; Liopo, Anton V. ; Slychenkov, V. S. ; Deitrich, Richard A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4386-9b29b7a81074163ae7b1a735634a336f4686dbc5b36cd33ced5c67dc154af4b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Acetaldehyde</topic><topic>Acetaldehyde - metabolism</topic><topic>Alcohol Sensitivity</topic><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Behavior</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - enzymology</topic><topic>Brain - metabolism</topic><topic>Brain Ethanol Metabolism</topic><topic>Catalase - metabolism</topic><topic>Central Nervous System Depressants - metabolism</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Ethanol - metabolism</topic><topic>Ethanol - pharmacology</topic><topic>Hypnotics and Sedatives - pharmacology</topic><topic>Hypnotics. Sedatives</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Sleep - drug effects</topic><topic>Sleep - genetics</topic><topic>Time Factors</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zimatkin, Sergey M.</creatorcontrib><creatorcontrib>Liopo, Anton V.</creatorcontrib><creatorcontrib>Slychenkov, V. S.</creatorcontrib><creatorcontrib>Deitrich, Richard A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alcoholism, clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zimatkin, Sergey M.</au><au>Liopo, Anton V.</au><au>Slychenkov, V. S.</au><au>Deitrich, Richard A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of Brain Ethanol Metabolism to the Hypnotic Effect of Ethanol. I: Studies in Outbred Animals</atitle><jtitle>Alcoholism, clinical and experimental research</jtitle><addtitle>Alcohol Clin Exp Res</addtitle><date>2001-07</date><risdate>2001</risdate><volume>25</volume><issue>7</issue><spage>976</spage><epage>981</epage><pages>976-981</pages><issn>0145-6008</issn><eissn>1530-0277</eissn><coden>ACRSDM</coden><abstract>Background : This study was designed to investigate the relationship between the ethanol‐oxidizing capacity of the brain, accumulation of acetaldehyde, and ethanol‐induced hypnosis in animals in vivo.
Methods: Randomly outbred albino rats were treated with ethanol, and the duration of ethanol‐induced loss of the righting response (sleep time) was measured. They were killed 2 weeks later (without further in vivo administration of ethanol), and brain homogenates were prepared to measure the accumulation of acetaldehyde from ethanol added in vitro. In a similar way, we determined the sleep time and, 5 days later, the rates of acetaldehyde accumulation in brains of heterogeneous mice.
Results: Significant correlations between the duration of ethanol‐induced sleep and acetaldehyde accumulation in vitro were found. The Km value of the process of acetaldehyde accumulation was lower in long‐sleeping, as compared with short‐sleeping, rats. A similar result was also obtained in genetically heterogeneous mice. Animals with a longer duration of ethanol‐induced sleep had a higher level of the accumulation of ethanol‐derived acetaldehyde in brain homogenates, as compared with the short‐sleeping mice. Rats and mice with the intermediate duration of ethanol‐induced sleep had an intermediate value of acetaldehyde accumulation in brain homogenates. There was no correlation between brain catalase activity and ethanol‐induced loss of the righting response in either the rats or the mice.
Conclusions: This study is a direct demonstration of the positive correlation between ethanol‐derived acetaldehyde accumulation in vitro in the brain and a central (behavioral) effect of alcohol in outbred rats and mice in vivo.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>11505021</pmid><doi>10.1111/j.1530-0277.2001.tb02305.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0145-6008 |
| ispartof | Alcoholism, clinical and experimental research, 2001-07, Vol.25 (7), p.976-981 |
| issn | 0145-6008 1530-0277 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71087953 |
| source | MEDLINE; Journals@Ovid Complete; Access via Wiley Online Library |
| subjects | Acetaldehyde Acetaldehyde - metabolism Alcohol Sensitivity Alcoholism and acute alcohol poisoning Animals Behavior Biological and medical sciences Brain - drug effects Brain - enzymology Brain - metabolism Brain Ethanol Metabolism Catalase - metabolism Central Nervous System Depressants - metabolism Central Nervous System Depressants - pharmacology Ethanol - metabolism Ethanol - pharmacology Hypnotics and Sedatives - pharmacology Hypnotics. Sedatives Kinetics Male Medical sciences Neuropharmacology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Sleep - drug effects Sleep - genetics Time Factors Toxicology |
| title | Relationship of Brain Ethanol Metabolism to the Hypnotic Effect of Ethanol. I: Studies in Outbred Animals |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-13T13%3A10%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20of%20Brain%20Ethanol%20Metabolism%20to%20the%20Hypnotic%20Effect%20of%20Ethanol.%20I:%20Studies%20in%20Outbred%20Animals&rft.jtitle=Alcoholism,%20clinical%20and%20experimental%20research&rft.au=Zimatkin,%20Sergey%20M.&rft.date=2001-07&rft.volume=25&rft.issue=7&rft.spage=976&rft.epage=981&rft.pages=976-981&rft.issn=0145-6008&rft.eissn=1530-0277&rft.coden=ACRSDM&rft_id=info:doi/10.1111/j.1530-0277.2001.tb02305.x&rft_dat=%3Cproquest_cross%3E71087953%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71087953&rft_id=info:pmid/11505021&rfr_iscdi=true |