Increased activity of nm23-H1 gene in squamous cell carcinoma of the head and neck is associated with advanced disease and poor prognosis

The present study was undertaken to determine whether the nm23-H1 gene is expressed in squamous cell carcinoma of the head and neck (SCCHN) and whether the level of nm23-H1 protein or mRNA in cells vary as they progress to a more malignant phenotype. Of the 120 SCCHN studied 54 (45%) stained positiv...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2000-01, Vol.78 (2), p.111-118
Hauptverfasser:	PAVELIC, K, KAPITANOVIC, S, RADOSEVIC, S, BURA, M, SEIWERTH, S, PAVELIC, L. J, UNUSIC, J, SPAVENTI, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Dysplasia Female Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - mortality Humans Immunohistochemistry Male Medical sciences Middle Aged Monomeric GTP-Binding Proteins - genetics Monomeric GTP-Binding Proteins - metabolism NM23 Nucleoside Diphosphate Kinases Nucleoside-Diphosphate Kinase Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Prognosis RNA, Messenger - metabolism Survival Rate Transcription Factors - genetics Transcription Factors - metabolism Tumors
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Zusammenfassung:	The present study was undertaken to determine whether the nm23-H1 gene is expressed in squamous cell carcinoma of the head and neck (SCCHN) and whether the level of nm23-H1 protein or mRNA in cells vary as they progress to a more malignant phenotype. Of the 120 SCCHN studied 54 (45%) stained positively for nm23-H1 protein. Protein expression was significantly higher in more advanced stages of disease. Expression of nm23-H1 was significantly higher in cancer tissues than in normal, adjacent tissue, dysplasia, or carcinoma in situ. The nm23-H1 rate increased with progression of synchronous lesions from dysplasia to carcinoma in situ and finally to carcinoma (P
ISSN:	0946-2716 1432-1440
DOI:	10.1007/s001090000081