Novel lipid-based hollow-porous microparticles as a platform for immunoglobulin delivery to the respiratory tract

Delivery of specific antibodies or immunoglobulin constructs to the respiratory tract may be useful for prophylaxis or active treatment of local or systemic disorders. Therefore, we evaluated the utility of lipid-based hollow-porous microparticles (PulmoSpheres) as a potential delivery vehicle for i...

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Veröffentlicht in:	Pharmaceutical research 2000-03, Vol.17 (3), p.275-283
Hauptverfasser:	BOT, A. I, TARARA, T. E, SMITH, D. J, BOT, S. R, WOODS, C. M, WEERS, J. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosols Animals Antibodies Antigens Biological activity Biological and medical sciences Disease prevention Drug Delivery Systems Enzyme-Linked Immunosorbent Assay Epitopes - immunology Female Fluorescent Dyes General pharmacology Hemagglutinin Glycoproteins, Influenza Virus - pharmacology Humans Immunoglobulin G - immunology Immunoglobulin G - pharmacology Immunoglobulins Immunomodulators Lipids Lipids - pharmacokinetics Lung - immunology Lung - metabolism Lymphocytes Medical sciences Mice Mice, Inbred BALB C Microspheres Particle Size Peptide Fragments - immunology Peptide Fragments - pharmacokinetics Peptides Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rats Rats, Sprague-Dawley
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