Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene

We have isolated and characterized the human homolog of the rat largest urea transporter of the UT-A family (hUT-A1). The 4.2-kb hUT-A1 cDNA encodes a 920-amino acid peptide, which is 89% identical to the rat UT-A1 protein. By Northern hybridization, hUT-A1 expression is detected in the human inner...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2001-09, Vol.281 (3), p.F400-F406
Hauptverfasser:	Bagnasco, S M, Peng, T, Janech, M G, Karakashian, A, Sands, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Carrier Proteins - analysis Carrier Proteins - chemistry Carrier Proteins - genetics Cell Line Chromosome Mapping Chromosomes, Human, Pair 18 Cloning, Molecular Exons Humans Kidney Medulla - physiology Kidney Tubules, Collecting - physiology Membrane Glycoproteins - analysis Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Transport Proteins Molecular Sequence Data Protein Biosynthesis Rats Reverse Transcriptase Polymerase Chain Reaction Sequence Alignment Sequence Homology, Amino Acid Transcription, Genetic Transfection Urea - metabolism Urea Transporters
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