p53 and bcl-2 in Epithelial Ovarian Carcinoma: Their Value as Prognostic Indicators at a Median Follow-up of 60 Months

Objective. p53 is the most common tumor suppressor gene involved with human malignancies. Mutations in p53 are present in approximately 50% of human malignancies. bcl-2 is a protooncogene. Expression of its protein product is related to better prognosis in several malignancies. Methods. One hundred...

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Veröffentlicht in:	Gynecologic oncology 2000-05, Vol.77 (2), p.278-282
Hauptverfasser:	Geisler, John P., Geisler, Hans E., Miller, Greg A., Wiemann, Michael C., Zhou, Zhen, Crabtree, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged bcl-2 Biomarkers, Tumor - analysis Carcinoma - genetics Carcinoma - pathology Carcinoma - therapy DNA Mutational Analysis DNA, Neoplasm - analysis Female Follow-Up Studies Genes, bcl-2 - genetics Genes, p53 - genetics Humans Middle Aged ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy p53 Predictive Value of Tests Prognosis survival Survival Analysis
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