The pathology of liver-localized post-transplant lymphoproliferative disease : A report of three cases and a review of the literature
Post-transplantation lymphoproliferative disease (PTLD) is a complication of solid organ transplantation that is typically of B-cell origin and associated with Epstein-Barr virus (EBV). In patients receiving orthotopic liver transplantation (OLT) and treated with cyclosporin A. PTLD typically presen...
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| Veröffentlicht in: | The American journal of surgical pathology 2000-05, Vol.24 (5), p.733-741 |
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| container_title | The American journal of surgical pathology |
| container_volume | 24 |
| creator | NUCKOLS, J. D BARON, P. W STENZEL, T. T OLATIDOYE, B. A TUTTLE-NEWHALL, J. E CLAVIEN, P.-A HOWELL, D. N |
| description | Post-transplantation lymphoproliferative disease (PTLD) is a complication of solid organ transplantation that is typically of B-cell origin and associated with Epstein-Barr virus (EBV). In patients receiving orthotopic liver transplantation (OLT) and treated with cyclosporin A. PTLD typically presents between 6 and 17 months post-transplantation as a systemic illness with involvement of the hepatic graft in a minority of cases. A small number of cases of biopsy-proven PTLD arising in the hepatic graft and limited to the liver and periportal structures have been previously reported. This report describes three additional cases of liver-localized PTLD and reviews similar cases in the literature. The donor/host origin of PTLD may have prognostic significance because the two cases in this report that are of donor origin had different clinical and pathologic features compared with the case of host origin. A rapid PCR-based technique for determining the origin of PTLD is described. |
| doi_str_mv | 10.1097/00000478-200005000-00013 |
| format | Article |
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The donor/host origin of PTLD may have prognostic significance because the two cases in this report that are of donor origin had different clinical and pathologic features compared with the case of host origin. A rapid PCR-based technique for determining the origin of PTLD is described.</description><identifier>ISSN: 0147-5185</identifier><identifier>EISSN: 1532-0979</identifier><identifier>DOI: 10.1097/00000478-200005000-00013</identifier><identifier>PMID: 10800993</identifier><identifier>CODEN: AJSPDX</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Biological and medical sciences ; DNA, Neoplasm - genetics ; Female ; Genotype ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. 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A small number of cases of biopsy-proven PTLD arising in the hepatic graft and limited to the liver and periportal structures have been previously reported. This report describes three additional cases of liver-localized PTLD and reviews similar cases in the literature. The donor/host origin of PTLD may have prognostic significance because the two cases in this report that are of donor origin had different clinical and pathologic features compared with the case of host origin. A rapid PCR-based technique for determining the origin of PTLD is described.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>DNA, Neoplasm - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Liver Diseases - etiology</subject><subject>Liver Diseases - pathology</subject><subject>Liver Transplantation</subject><subject>Lymphoproliferative Disorders - etiology</subject><subject>Lymphoproliferative Disorders - genetics</subject><subject>Lymphoproliferative Disorders - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Postoperative Complications - pathology</subject><issn>0147-5185</issn><issn>1532-0979</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkU1vGyEQhlHVKnbd_IWIQ9UbDbCwu_RmRfmSLOXi-wqzs_FW2GwAu3Lu_d-ZzbofSIiPeWYG3pcQKvh3wU11zcehqprJcaNxMpyi-EDmQheSIWM-kjkXqmJa1HpGPqf0EwlZC3lBZoLXnBtTzMnv9RboYPM2-PB8oqGjvj9CZD446_tXaOkQUmY52n0avN1n6k-7YRuGGHzfQbQZcdr2CWwC-oMuaYQhxDxWytsIQB0GErX7llqMHXv4NcUAO-WxwCHCF_Kpsz7B5XldkPXd7frmga2e7h9vlivmZK0zc8rasuTKGStk10quW2lKPNRmM945I4UrnVatUrzQRems0dKWYqNByapYkG9TWXz9ywFSbnZ9cuDxXxAOqalQFy0MR7CeQBdDShG6Zoj9zsZTI3gzOtD8caD560Dz7gCmXp17HDY7aP9LnCRH4OsZsAk17lBZ16d_XKGVELJ4AyHgj10</recordid><startdate>20000501</startdate><enddate>20000501</enddate><creator>NUCKOLS, J. 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A small number of cases of biopsy-proven PTLD arising in the hepatic graft and limited to the liver and periportal structures have been previously reported. This report describes three additional cases of liver-localized PTLD and reviews similar cases in the literature. The donor/host origin of PTLD may have prognostic significance because the two cases in this report that are of donor origin had different clinical and pathologic features compared with the case of host origin. A rapid PCR-based technique for determining the origin of PTLD is described.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10800993</pmid><doi>10.1097/00000478-200005000-00013</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0147-5185 |
| ispartof | The American journal of surgical pathology, 2000-05, Vol.24 (5), p.733-741 |
| issn | 0147-5185 1532-0979 |
| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE |
| subjects | Adult Biological and medical sciences DNA, Neoplasm - genetics Female Genotype Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Liver Diseases - etiology Liver Diseases - pathology Liver Transplantation Lymphoproliferative Disorders - etiology Lymphoproliferative Disorders - genetics Lymphoproliferative Disorders - pathology Male Medical sciences Middle Aged Postoperative Complications - pathology |
| title | The pathology of liver-localized post-transplant lymphoproliferative disease : A report of three cases and a review of the literature |
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