Imprinting and the Epigenetic Asymmetry between Parental Genomes

Genomic imprinting confers a developmental asymmetry on the parental genomes, through epigenetic modifications in the germ line and embryo. These heritable modifications regulate the monoallelic activity of parental alleles resulting in their functional differences during development. Specific cis-a...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2001-08, Vol.293 (5532), p.1086-1089
Hauptverfasser:	Ferguson-Smith, Anne C., Surani, M. Azim
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles DNA DNA Methylation Embryonic and Fetal Development Embryos Epigenetics Evolution, Molecular Female Gametogenesis Gene Expression Regulation, Developmental Gene Silencing Genes Genetic aspects Genetic loci Genetic transcription Genomes Genomic Imprinting Genomics Germ cells Germ Cells - metabolism Humans Male Methylation Oocytes - metabolism Regulatory Sequences, Nucleic Acid RNA, Antisense - genetics Transcription (Genetics) Viewpoints and Reviews Zygote - metabolism
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