Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells
Background: The role of T cell subpopulations and their ability to produce immunoregulatory cytokines has been extensively studied in multiple sclerosis (MS). However, the exact mechanisms by which T cells and cytokines contribute to disease activity remain to be clarified. Objectives: To analyze th...
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| Veröffentlicht in: | Journal of neuroimmunology 2001-08, Vol.118 (2), p.286-294 |
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| container_end_page | 294 |
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| container_title | Journal of neuroimmunology |
| container_volume | 118 |
| creator | Killestein, Joep Rep, Martin H.G Barkhof, Frederik Roos, Marijke T.L Adèr, Herman J van Lier, René A.W Polman, Chris H |
| description | Background: The role of T cell subpopulations and their ability to produce immunoregulatory cytokines has been extensively studied in multiple sclerosis (MS). However, the exact mechanisms by which T cells and cytokines contribute to disease activity remain to be clarified.
Objectives: To analyze the longitudinal relation between markers of T cell activation and differentiation and disease activity in MS patients.
Methods: During a period of 9 months, clinical disease activity was scored, monthly MRI scans were performed, and blood was taken for immune measurements in a group of 13 untreated clinically definite MS patients.
Results: Disease activity, as measured by the occurrence of active MRI lesions, is associated with a significant transient decrease in both T cells producing interferon-γ (IFN-γ) and T cells producing interleukin (IL)-4.
Conclusions: Our results suggest that MRI-documented disease activity is associated with a transient decrease in circulating cytokine producing T cells, possibly due to the migration of activated T cells into the CNS. |
| doi_str_mv | 10.1016/S0165-5728(01)00346-0 |
| format | Article |
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Objectives: To analyze the longitudinal relation between markers of T cell activation and differentiation and disease activity in MS patients.
Methods: During a period of 9 months, clinical disease activity was scored, monthly MRI scans were performed, and blood was taken for immune measurements in a group of 13 untreated clinically definite MS patients.
Results: Disease activity, as measured by the occurrence of active MRI lesions, is associated with a significant transient decrease in both T cells producing interferon-γ (IFN-γ) and T cells producing interleukin (IL)-4.
Conclusions: Our results suggest that MRI-documented disease activity is associated with a transient decrease in circulating cytokine producing T cells, possibly due to the migration of activated T cells into the CNS.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/S0165-5728(01)00346-0</identifier><identifier>PMID: 11498263</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Antibodies, Monoclonal - therapeutic use ; Cell Count ; Cytokines ; Disease activity ; Disease Progression ; Double-Blind Method ; Female ; Follow-Up Studies ; Humans ; Interferon-gamma - biosynthesis ; Interleukin-4 - biosynthesis ; Magnetic Resonance Imaging ; Male ; Methylprednisolone - therapeutic use ; MRI ; Multiple sclerosis ; Multiple Sclerosis - diagnosis ; Multiple Sclerosis - drug therapy ; Multiple Sclerosis - immunology ; Predictive Value of Tests ; T cells ; Th1 Cells - cytology ; Th1 Cells - metabolism ; Th2 Cells - cytology ; Th2 Cells - metabolism</subject><ispartof>Journal of neuroimmunology, 2001-08, Vol.118 (2), p.286-294</ispartof><rights>2001 Elsevier Science B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-5df7f433eefd5a3361373718529087fc894d1867ab217d53b917ab3102c8bdee3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0165-5728(01)00346-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11498263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Killestein, Joep</creatorcontrib><creatorcontrib>Rep, Martin H.G</creatorcontrib><creatorcontrib>Barkhof, Frederik</creatorcontrib><creatorcontrib>Roos, Marijke T.L</creatorcontrib><creatorcontrib>Adèr, Herman J</creatorcontrib><creatorcontrib>van Lier, René A.W</creatorcontrib><creatorcontrib>Polman, Chris H</creatorcontrib><title>Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Background: The role of T cell subpopulations and their ability to produce immunoregulatory cytokines has been extensively studied in multiple sclerosis (MS). However, the exact mechanisms by which T cells and cytokines contribute to disease activity remain to be clarified.
Objectives: To analyze the longitudinal relation between markers of T cell activation and differentiation and disease activity in MS patients.
Methods: During a period of 9 months, clinical disease activity was scored, monthly MRI scans were performed, and blood was taken for immune measurements in a group of 13 untreated clinically definite MS patients.
Results: Disease activity, as measured by the occurrence of active MRI lesions, is associated with a significant transient decrease in both T cells producing interferon-γ (IFN-γ) and T cells producing interleukin (IL)-4.
Conclusions: Our results suggest that MRI-documented disease activity is associated with a transient decrease in circulating cytokine producing T cells, possibly due to the migration of activated T cells into the CNS.</description><subject>Adult</subject><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Cell Count</subject><subject>Cytokines</subject><subject>Disease activity</subject><subject>Disease Progression</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Methylprednisolone - therapeutic use</subject><subject>MRI</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - diagnosis</subject><subject>Multiple Sclerosis - drug therapy</subject><subject>Multiple Sclerosis - immunology</subject><subject>Predictive Value of Tests</subject><subject>T cells</subject><subject>Th1 Cells - cytology</subject><subject>Th1 Cells - metabolism</subject><subject>Th2 Cells - cytology</subject><subject>Th2 Cells - metabolism</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctKxTAQhoMoerw8gpKV6KKaSdomXYmIN1AEL-uQJlON9LQ1aQXf3hzPQZduciHfzITvJ2Qf2AkwKE-f0lJkheTqiMExYyIvM7ZGZqAkz1TOYZ3MfpEtsh3jO2NQiLzaJFsAeaV4KWZkfm5H_4n0_vGWthh931EzDGiC6SxS39H7JzqY0WM3RuojHQJadOho_UWbdrLjlB77Li5Q64Od2nTvXulz9obtgIECNZ2jnFps27hLNhrTRtxb7Tvk5ery-eImu3u4vr04v8usqPiYFa6RTS4EYuMKI0QJQgoJquAVU7KxqsodqFKamoN0hagrSGcBjFtVO0SxQw6XfYfQf0wYRz33cfED02E_RS2BqVww9S8ICkqpIE9gsQRt6GMM2Ogh-LkJXxqYXgSifwLRC9uagf4JRLNUd7AaMNVzdH9VqwQScLYEMPn49Bh0tMl2kuyT6lG73v8z4huTSply</recordid><startdate>20010830</startdate><enddate>20010830</enddate><creator>Killestein, Joep</creator><creator>Rep, Martin H.G</creator><creator>Barkhof, Frederik</creator><creator>Roos, Marijke T.L</creator><creator>Adèr, Herman J</creator><creator>van Lier, René A.W</creator><creator>Polman, Chris H</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010830</creationdate><title>Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells</title><author>Killestein, Joep ; Rep, Martin H.G ; Barkhof, Frederik ; Roos, Marijke T.L ; Adèr, Herman J ; van Lier, René A.W ; Polman, Chris H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-5df7f433eefd5a3361373718529087fc894d1867ab217d53b917ab3102c8bdee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Antibodies, Monoclonal - therapeutic use</topic><topic>Cell Count</topic><topic>Cytokines</topic><topic>Disease activity</topic><topic>Disease Progression</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Methylprednisolone - therapeutic use</topic><topic>MRI</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - diagnosis</topic><topic>Multiple Sclerosis - drug therapy</topic><topic>Multiple Sclerosis - immunology</topic><topic>Predictive Value of Tests</topic><topic>T cells</topic><topic>Th1 Cells - cytology</topic><topic>Th1 Cells - metabolism</topic><topic>Th2 Cells - cytology</topic><topic>Th2 Cells - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Killestein, Joep</creatorcontrib><creatorcontrib>Rep, Martin H.G</creatorcontrib><creatorcontrib>Barkhof, Frederik</creatorcontrib><creatorcontrib>Roos, Marijke T.L</creatorcontrib><creatorcontrib>Adèr, Herman J</creatorcontrib><creatorcontrib>van Lier, René A.W</creatorcontrib><creatorcontrib>Polman, Chris H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Killestein, Joep</au><au>Rep, Martin H.G</au><au>Barkhof, Frederik</au><au>Roos, Marijke T.L</au><au>Adèr, Herman J</au><au>van Lier, René A.W</au><au>Polman, Chris H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2001-08-30</date><risdate>2001</risdate><volume>118</volume><issue>2</issue><spage>286</spage><epage>294</epage><pages>286-294</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Background: The role of T cell subpopulations and their ability to produce immunoregulatory cytokines has been extensively studied in multiple sclerosis (MS). However, the exact mechanisms by which T cells and cytokines contribute to disease activity remain to be clarified.
Objectives: To analyze the longitudinal relation between markers of T cell activation and differentiation and disease activity in MS patients.
Methods: During a period of 9 months, clinical disease activity was scored, monthly MRI scans were performed, and blood was taken for immune measurements in a group of 13 untreated clinically definite MS patients.
Results: Disease activity, as measured by the occurrence of active MRI lesions, is associated with a significant transient decrease in both T cells producing interferon-γ (IFN-γ) and T cells producing interleukin (IL)-4.
Conclusions: Our results suggest that MRI-documented disease activity is associated with a transient decrease in circulating cytokine producing T cells, possibly due to the migration of activated T cells into the CNS.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>11498263</pmid><doi>10.1016/S0165-5728(01)00346-0</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adult Antibodies, Monoclonal - therapeutic use Cell Count Cytokines Disease activity Disease Progression Double-Blind Method Female Follow-Up Studies Humans Interferon-gamma - biosynthesis Interleukin-4 - biosynthesis Magnetic Resonance Imaging Male Methylprednisolone - therapeutic use MRI Multiple sclerosis Multiple Sclerosis - diagnosis Multiple Sclerosis - drug therapy Multiple Sclerosis - immunology Predictive Value of Tests T cells Th1 Cells - cytology Th1 Cells - metabolism Th2 Cells - cytology Th2 Cells - metabolism |
| title | Active MRI lesion appearance in MS patients is preceded by fluctuations in circulating T-helper 1 and 2 cells |
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