Changes in Blood Flow in the Partially Elevated Epigastric Pedicled Flap in Response to Occlusion of the Femoral Artery in Rats
ABSTRACT In this study, the authors used a custom-designed clamping method and laser Doppler flowmetry to investigate the short-term autoregulatory patterns of blood flow (BF) in partially elevated pedicled epigastric flaps in rats (n=11). The femoral artery was clamped for 30, 60, 120 and 180 sec d...
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| Veröffentlicht in: | Journal of reconstructive microsurgery 2001-07, Vol.17 (5), p.371-378 |
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| container_title | Journal of reconstructive microsurgery |
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| creator | Kinnunen, Ilpo Laurikainen, Esa Schrey, Aleksi Laippala, Pekka Aitasalo, Kalle |
| description | ABSTRACT
In this study, the authors used a custom-designed clamping method and laser Doppler flowmetry to investigate the short-term autoregulatory patterns of blood flow (BF) in partially elevated pedicled epigastric flaps in rats (n=11). The femoral artery was clamped for 30, 60, 120 and 180 sec directly after flap elevation and 40 to 80 min after flap elevation. Changes during and after clamping indicate the functioning of autoregulatory factors in the vessels of the epigastric partially elevated flap. The longer the clamp ischemia is in a flap, the greater (P < 0.0001) is the need for a compensatory increase in BF and for a longer time (P < 0.0001) in the flap after clamp release. They compared the responses of BF directly after flap elevation with those 40 to 80 min after flap elevation. The results suggest a significant increase in the autoregulatory capacity of the pedicled partially elevated flap in measurements performed 40 to 80 min after flap elevation (P = 0.043). They conclude that the novel clamping method seems to be reliable when studying the short-term autoregulatory patterns of the epigastric partially elevated pedicled flap. |
| doi_str_mv | 10.1055/s-2001-16030 |
| format | Article |
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In this study, the authors used a custom-designed clamping method and laser Doppler flowmetry to investigate the short-term autoregulatory patterns of blood flow (BF) in partially elevated pedicled epigastric flaps in rats (n=11). The femoral artery was clamped for 30, 60, 120 and 180 sec directly after flap elevation and 40 to 80 min after flap elevation. Changes during and after clamping indicate the functioning of autoregulatory factors in the vessels of the epigastric partially elevated flap. The longer the clamp ischemia is in a flap, the greater (P < 0.0001) is the need for a compensatory increase in BF and for a longer time (P < 0.0001) in the flap after clamp release. They compared the responses of BF directly after flap elevation with those 40 to 80 min after flap elevation. The results suggest a significant increase in the autoregulatory capacity of the pedicled partially elevated flap in measurements performed 40 to 80 min after flap elevation (P = 0.043). They conclude that the novel clamping method seems to be reliable when studying the short-term autoregulatory patterns of the epigastric partially elevated pedicled flap.</description><identifier>ISSN: 0743-684X</identifier><identifier>EISSN: 1098-8947</identifier><identifier>DOI: 10.1055/s-2001-16030</identifier><identifier>PMID: 11499472</identifier><identifier>CODEN: JRMIE2</identifier><language>eng</language><publisher>New York, NY: Thieme</publisher><subject>Animals ; Biological and medical sciences ; Constriction ; Constriction, Pathologic - physiopathology ; Disease Models, Animal ; Epigastric Arteries - physiopathology ; Epigastric Arteries - surgery ; Femoral Artery - physiopathology ; Hemodynamics - physiology ; Homeostasis - physiology ; IDEAS AND INNOVATIONS ; Laser-Doppler Flowmetry ; Medical sciences ; Microsurgery ; Miscellaneous ; Rats ; Rats, Sprague-Dawley ; Regional Blood Flow - physiology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical Flaps - blood supply ; Surgical Flaps - physiology ; Time Factors ; Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><ispartof>Journal of reconstructive microsurgery, 2001-07, Vol.17 (5), p.371-378</ispartof><rights>Copyright © 2001 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-619b4a751f8e8a7e958d20fde8a165dd2bcaf88281612673d7abcc008b9654ce3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2001-16030.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2001-16030$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3017,3018,27924,27925,54559,54560</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1102401$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11499472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kinnunen, Ilpo</creatorcontrib><creatorcontrib>Laurikainen, Esa</creatorcontrib><creatorcontrib>Schrey, Aleksi</creatorcontrib><creatorcontrib>Laippala, Pekka</creatorcontrib><creatorcontrib>Aitasalo, Kalle</creatorcontrib><title>Changes in Blood Flow in the Partially Elevated Epigastric Pedicled Flap in Response to Occlusion of the Femoral Artery in Rats</title><title>Journal of reconstructive microsurgery</title><addtitle>J reconstr Microsurg</addtitle><description>ABSTRACT
In this study, the authors used a custom-designed clamping method and laser Doppler flowmetry to investigate the short-term autoregulatory patterns of blood flow (BF) in partially elevated pedicled epigastric flaps in rats (n=11). The femoral artery was clamped for 30, 60, 120 and 180 sec directly after flap elevation and 40 to 80 min after flap elevation. Changes during and after clamping indicate the functioning of autoregulatory factors in the vessels of the epigastric partially elevated flap. The longer the clamp ischemia is in a flap, the greater (P < 0.0001) is the need for a compensatory increase in BF and for a longer time (P < 0.0001) in the flap after clamp release. They compared the responses of BF directly after flap elevation with those 40 to 80 min after flap elevation. The results suggest a significant increase in the autoregulatory capacity of the pedicled partially elevated flap in measurements performed 40 to 80 min after flap elevation (P = 0.043). They conclude that the novel clamping method seems to be reliable when studying the short-term autoregulatory patterns of the epigastric partially elevated pedicled flap.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Constriction</subject><subject>Constriction, Pathologic - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Epigastric Arteries - physiopathology</subject><subject>Epigastric Arteries - surgery</subject><subject>Femoral Artery - physiopathology</subject><subject>Hemodynamics - physiology</subject><subject>Homeostasis - physiology</subject><subject>IDEAS AND INNOVATIONS</subject><subject>Laser-Doppler Flowmetry</subject><subject>Medical sciences</subject><subject>Microsurgery</subject><subject>Miscellaneous</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Regional Blood Flow - physiology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical Flaps - blood supply</subject><subject>Surgical Flaps - physiology</subject><subject>Time Factors</subject><subject>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</subject><issn>0743-684X</issn><issn>1098-8947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0M9rFDEUB_AgFrtWb54lB_Gio0nmV-bYLrtaKLSIgreQSd50UzKTMS-j7Ml_3ZndhfbgKXnwed8HX0LecPaJs7L8jJlgjGe8Yjl7RlacNTKTTVE_JytWF3lWyeLnOXmJ-DCzouHiBTnn82cmYkX-rnd6uAekbqBXPgRLtz78Waa0A3qnY3La-z3dePitE1i6Gd29xhSdoXdgnfGwrOhxWfkGOIYBgaZAb43xE7ow0NAdsrbQh6g9vYwJ4v7AdcJX5KzTHuH16b0gP7ab7-uv2c3tl-v15U1m8lKkrOJNW-i65J0EqWtoSmkF6-w88Kq0VrRGd1IKySsuqjq3tW6NYUy2TVUWBvIL8v6YO8bwawJMqndowHs9QJhQ1ZzJvKr4DD8eoYkBMUKnxuh6HfeKM7UUrlAthatD4TN_e8qd2h7sIz41PIN3J6DRaN9FPRiHTxwTBVvOfjiytHPQg3oIUxzmQv5_9R_QOZXD</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>Kinnunen, Ilpo</creator><creator>Laurikainen, Esa</creator><creator>Schrey, Aleksi</creator><creator>Laippala, Pekka</creator><creator>Aitasalo, Kalle</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>Changes in Blood Flow in the Partially Elevated Epigastric Pedicled Flap in Response to Occlusion of the Femoral Artery in Rats</title><author>Kinnunen, Ilpo ; Laurikainen, Esa ; Schrey, Aleksi ; Laippala, Pekka ; Aitasalo, Kalle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-619b4a751f8e8a7e958d20fde8a165dd2bcaf88281612673d7abcc008b9654ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Constriction</topic><topic>Constriction, Pathologic - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Epigastric Arteries - physiopathology</topic><topic>Epigastric Arteries - surgery</topic><topic>Femoral Artery - physiopathology</topic><topic>Hemodynamics - physiology</topic><topic>Homeostasis - physiology</topic><topic>IDEAS AND INNOVATIONS</topic><topic>Laser-Doppler Flowmetry</topic><topic>Medical sciences</topic><topic>Microsurgery</topic><topic>Miscellaneous</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Regional Blood Flow - physiology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgical Flaps - blood supply</topic><topic>Surgical Flaps - physiology</topic><topic>Time Factors</topic><topic>Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kinnunen, Ilpo</creatorcontrib><creatorcontrib>Laurikainen, Esa</creatorcontrib><creatorcontrib>Schrey, Aleksi</creatorcontrib><creatorcontrib>Laippala, Pekka</creatorcontrib><creatorcontrib>Aitasalo, Kalle</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reconstructive microsurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kinnunen, Ilpo</au><au>Laurikainen, Esa</au><au>Schrey, Aleksi</au><au>Laippala, Pekka</au><au>Aitasalo, Kalle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in Blood Flow in the Partially Elevated Epigastric Pedicled Flap in Response to Occlusion of the Femoral Artery in Rats</atitle><jtitle>Journal of reconstructive microsurgery</jtitle><addtitle>J reconstr Microsurg</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>17</volume><issue>5</issue><spage>371</spage><epage>378</epage><pages>371-378</pages><issn>0743-684X</issn><eissn>1098-8947</eissn><coden>JRMIE2</coden><abstract>ABSTRACT
In this study, the authors used a custom-designed clamping method and laser Doppler flowmetry to investigate the short-term autoregulatory patterns of blood flow (BF) in partially elevated pedicled epigastric flaps in rats (n=11). The femoral artery was clamped for 30, 60, 120 and 180 sec directly after flap elevation and 40 to 80 min after flap elevation. Changes during and after clamping indicate the functioning of autoregulatory factors in the vessels of the epigastric partially elevated flap. The longer the clamp ischemia is in a flap, the greater (P < 0.0001) is the need for a compensatory increase in BF and for a longer time (P < 0.0001) in the flap after clamp release. They compared the responses of BF directly after flap elevation with those 40 to 80 min after flap elevation. The results suggest a significant increase in the autoregulatory capacity of the pedicled partially elevated flap in measurements performed 40 to 80 min after flap elevation (P = 0.043). They conclude that the novel clamping method seems to be reliable when studying the short-term autoregulatory patterns of the epigastric partially elevated pedicled flap.</abstract><cop>New York, NY</cop><pub>Thieme</pub><pmid>11499472</pmid><doi>10.1055/s-2001-16030</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Constriction Constriction, Pathologic - physiopathology Disease Models, Animal Epigastric Arteries - physiopathology Epigastric Arteries - surgery Femoral Artery - physiopathology Hemodynamics - physiology Homeostasis - physiology IDEAS AND INNOVATIONS Laser-Doppler Flowmetry Medical sciences Microsurgery Miscellaneous Rats Rats, Sprague-Dawley Regional Blood Flow - physiology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical Flaps - blood supply Surgical Flaps - physiology Time Factors Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels |
| title | Changes in Blood Flow in the Partially Elevated Epigastric Pedicled Flap in Response to Occlusion of the Femoral Artery in Rats |
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