Relationship Between Acute Morphine and the Course of PTSD in Children With Burns
To investigate the relationship between the dose of morphine administered during a child's hospitalization for an acute burn and the course of posttraumatic stress disorder (PTSD) symptoms over the 6-month period following discharge from the hospital. Twenty-four children admitted to the hospit...
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| Veröffentlicht in: | Journal of the American Academy of Child and Adolescent Psychiatry 2001-08, Vol.40 (8), p.915-921 |
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| container_title | Journal of the American Academy of Child and Adolescent Psychiatry |
| container_volume | 40 |
| creator | SAXE, GLENN STODDARD, FREDERICK COURTNEY, DIANE CUNNINGHAM, KELLY CHAWLA, NEHARIKA SHERIDAN, ROBERT KING, DANIEL KING, LYNDA |
| description | To investigate the relationship between the dose of morphine administered during a child's hospitalization for an acute burn and the course of posttraumatic stress disorder (PTSD) symptoms over the 6-month period following discharge from the hospital.
Twenty-four children admitted to the hospital for an acute burn were assessed twice with the Child PTSD Reaction Index: while in the hospital and 6 months after discharge. The Colored Analogue Pain Scale was also administered during the hospitalization. All patients received morphine while in the hospital. The mean dose of morphine (mg/kg/ day) was calculated for each subject through chart review.
The Pearson product moment correlation revealed a significant association between the dose of morphine received while in the hospital and a 6-month reduction in PTSD symptoms. Children receiving higher doses of morphine had a greater reduction in PTSD symptoms over 6 months.
This study suggests the possibility that acute treatment with morphine can secondarily prevent PTSD. This result is discussed in terms of the possible effect of morphine on fear conditioning and the consolidation of traumatic memory. |
| doi_str_mv | 10.1097/00004583-200108000-00013 |
| format | Article |
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Twenty-four children admitted to the hospital for an acute burn were assessed twice with the Child PTSD Reaction Index: while in the hospital and 6 months after discharge. The Colored Analogue Pain Scale was also administered during the hospitalization. All patients received morphine while in the hospital. The mean dose of morphine (mg/kg/ day) was calculated for each subject through chart review.
The Pearson product moment correlation revealed a significant association between the dose of morphine received while in the hospital and a 6-month reduction in PTSD symptoms. Children receiving higher doses of morphine had a greater reduction in PTSD symptoms over 6 months.
This study suggests the possibility that acute treatment with morphine can secondarily prevent PTSD. This result is discussed in terms of the possible effect of morphine on fear conditioning and the consolidation of traumatic memory.</description><identifier>ISSN: 0890-8567</identifier><identifier>EISSN: 1527-5418</identifier><identifier>DOI: 10.1097/00004583-200108000-00013</identifier><identifier>PMID: 11501691</identifier><identifier>CODEN: JAAPEE</identifier><language>eng</language><publisher>Hagerstown, MD: Elsevier Inc</publisher><subject>Adolescent ; Analgesics ; Analgesics, Opioid - administration & dosage ; Anxiety disorders ; Biological and medical sciences ; Burns ; Burns - drug therapy ; Burns - psychology ; Child ; Child clinical studies ; Child psychology ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Humans ; Male ; Medical sciences ; morphine ; Morphine - administration & dosage ; Narcotics ; Neuropharmacology ; Pain Measurement ; Pharmacology. Drug treatments ; Post traumatic stress disorder ; posttraumatic stress disorder ; Prevention ; Prospective Studies ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Research Design ; Sample Size ; Severity of Illness Index ; Stress Disorders, Post-Traumatic - etiology ; Stress Disorders, Post-Traumatic - prevention & control</subject><ispartof>Journal of the American Academy of Child and Adolescent Psychiatry, 2001-08, Vol.40 (8), p.915-921</ispartof><rights>2001 The American Academy of Child and Adolescent Psychiatry</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Aug 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-7cde3d43e70f855e2ecdd0588114332d9eefd6ef6fc4509d8bde2ed7737d37893</citedby><cites>FETCH-LOGICAL-c482t-7cde3d43e70f855e2ecdd0588114332d9eefd6ef6fc4509d8bde2ed7737d37893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1097/00004583-200108000-00013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,30999,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1049706$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11501691$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SAXE, GLENN</creatorcontrib><creatorcontrib>STODDARD, FREDERICK</creatorcontrib><creatorcontrib>COURTNEY, DIANE</creatorcontrib><creatorcontrib>CUNNINGHAM, KELLY</creatorcontrib><creatorcontrib>CHAWLA, NEHARIKA</creatorcontrib><creatorcontrib>SHERIDAN, ROBERT</creatorcontrib><creatorcontrib>KING, DANIEL</creatorcontrib><creatorcontrib>KING, LYNDA</creatorcontrib><title>Relationship Between Acute Morphine and the Course of PTSD in Children With Burns</title><title>Journal of the American Academy of Child and Adolescent Psychiatry</title><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><description>To investigate the relationship between the dose of morphine administered during a child's hospitalization for an acute burn and the course of posttraumatic stress disorder (PTSD) symptoms over the 6-month period following discharge from the hospital.
Twenty-four children admitted to the hospital for an acute burn were assessed twice with the Child PTSD Reaction Index: while in the hospital and 6 months after discharge. The Colored Analogue Pain Scale was also administered during the hospitalization. All patients received morphine while in the hospital. The mean dose of morphine (mg/kg/ day) was calculated for each subject through chart review.
The Pearson product moment correlation revealed a significant association between the dose of morphine received while in the hospital and a 6-month reduction in PTSD symptoms. Children receiving higher doses of morphine had a greater reduction in PTSD symptoms over 6 months.
This study suggests the possibility that acute treatment with morphine can secondarily prevent PTSD. This result is discussed in terms of the possible effect of morphine on fear conditioning and the consolidation of traumatic memory.</description><subject>Adolescent</subject><subject>Analgesics</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Anxiety disorders</subject><subject>Biological and medical sciences</subject><subject>Burns</subject><subject>Burns - drug therapy</subject><subject>Burns - psychology</subject><subject>Child</subject><subject>Child clinical studies</subject><subject>Child psychology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>morphine</subject><subject>Morphine - administration & dosage</subject><subject>Narcotics</subject><subject>Neuropharmacology</subject><subject>Pain Measurement</subject><subject>Pharmacology. Drug treatments</subject><subject>Post traumatic stress disorder</subject><subject>posttraumatic stress disorder</subject><subject>Prevention</subject><subject>Prospective Studies</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Research Design</subject><subject>Sample Size</subject><subject>Severity of Illness Index</subject><subject>Stress Disorders, Post-Traumatic - etiology</subject><subject>Stress Disorders, Post-Traumatic - prevention & control</subject><issn>0890-8567</issn><issn>1527-5418</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqFkF1r2zAUhsXoWNKsf6GIUXbnVrIkS75ssn4MMtptKbsUjnSMFRw5leyO_vsqTdqV3VQgxIHnPefoQQhTckpJKc9IOlwoluWEUKJSlaVL2Qc0piKXmeBUHaAxUSXJlCjkCB3GuNoiUqlPaESpILQo6Rj9_AVt1bvOx8Zt8BT6vwAen5uhB_yjC5vGecCVt7hvAM-6IUTAXY1vF7-_YefxrHGtDSnxx_UNng7Bx8_oY121EY727wTdXV4sZtfZ_Obq--x8nhmu8j6TxgKznIEktRICcjDWEqEUpZyx3JYAtS2gLmrDBSmtWtrEWCmZtEyqkk3Q113fTejuB4i9XrtooG0rD90QtUxiGM9JAr_8B67SP3zaTec0LziVaeIEqR1kQhdjgFpvgltX4VFTorfO9Ytz_epcPztP0eN9_2G5BvsvuJecgJM9UEVTtXWovHHxzQBeSlIkbLrDIFl7cBB0NA68AesCmF7bzr2_zBMznpuK</recordid><startdate>20010801</startdate><enddate>20010801</enddate><creator>SAXE, GLENN</creator><creator>STODDARD, FREDERICK</creator><creator>COURTNEY, DIANE</creator><creator>CUNNINGHAM, KELLY</creator><creator>CHAWLA, NEHARIKA</creator><creator>SHERIDAN, ROBERT</creator><creator>KING, DANIEL</creator><creator>KING, LYNDA</creator><general>Elsevier Inc</general><general>Lippincott</general><general>Elsevier BV</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QJ</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20010801</creationdate><title>Relationship Between Acute Morphine and the Course of PTSD in Children With Burns</title><author>SAXE, GLENN ; STODDARD, FREDERICK ; COURTNEY, DIANE ; CUNNINGHAM, KELLY ; CHAWLA, NEHARIKA ; SHERIDAN, ROBERT ; KING, DANIEL ; KING, LYNDA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-7cde3d43e70f855e2ecdd0588114332d9eefd6ef6fc4509d8bde2ed7737d37893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adolescent</topic><topic>Analgesics</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Anxiety disorders</topic><topic>Biological and medical sciences</topic><topic>Burns</topic><topic>Burns - drug therapy</topic><topic>Burns - psychology</topic><topic>Child</topic><topic>Child clinical studies</topic><topic>Child psychology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>morphine</topic><topic>Morphine - administration & dosage</topic><topic>Narcotics</topic><topic>Neuropharmacology</topic><topic>Pain Measurement</topic><topic>Pharmacology. Drug treatments</topic><topic>Post traumatic stress disorder</topic><topic>posttraumatic stress disorder</topic><topic>Prevention</topic><topic>Prospective Studies</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Research Design</topic><topic>Sample Size</topic><topic>Severity of Illness Index</topic><topic>Stress Disorders, Post-Traumatic - etiology</topic><topic>Stress Disorders, Post-Traumatic - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SAXE, GLENN</creatorcontrib><creatorcontrib>STODDARD, FREDERICK</creatorcontrib><creatorcontrib>COURTNEY, DIANE</creatorcontrib><creatorcontrib>CUNNINGHAM, KELLY</creatorcontrib><creatorcontrib>CHAWLA, NEHARIKA</creatorcontrib><creatorcontrib>SHERIDAN, ROBERT</creatorcontrib><creatorcontrib>KING, DANIEL</creatorcontrib><creatorcontrib>KING, LYNDA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SAXE, GLENN</au><au>STODDARD, FREDERICK</au><au>COURTNEY, DIANE</au><au>CUNNINGHAM, KELLY</au><au>CHAWLA, NEHARIKA</au><au>SHERIDAN, ROBERT</au><au>KING, DANIEL</au><au>KING, LYNDA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship Between Acute Morphine and the Course of PTSD in Children With Burns</atitle><jtitle>Journal of the American Academy of Child and Adolescent Psychiatry</jtitle><addtitle>J Am Acad Child Adolesc Psychiatry</addtitle><date>2001-08-01</date><risdate>2001</risdate><volume>40</volume><issue>8</issue><spage>915</spage><epage>921</epage><pages>915-921</pages><issn>0890-8567</issn><eissn>1527-5418</eissn><coden>JAAPEE</coden><abstract>To investigate the relationship between the dose of morphine administered during a child's hospitalization for an acute burn and the course of posttraumatic stress disorder (PTSD) symptoms over the 6-month period following discharge from the hospital.
Twenty-four children admitted to the hospital for an acute burn were assessed twice with the Child PTSD Reaction Index: while in the hospital and 6 months after discharge. The Colored Analogue Pain Scale was also administered during the hospitalization. All patients received morphine while in the hospital. The mean dose of morphine (mg/kg/ day) was calculated for each subject through chart review.
The Pearson product moment correlation revealed a significant association between the dose of morphine received while in the hospital and a 6-month reduction in PTSD symptoms. Children receiving higher doses of morphine had a greater reduction in PTSD symptoms over 6 months.
This study suggests the possibility that acute treatment with morphine can secondarily prevent PTSD. This result is discussed in terms of the possible effect of morphine on fear conditioning and the consolidation of traumatic memory.</abstract><cop>Hagerstown, MD</cop><pub>Elsevier Inc</pub><pmid>11501691</pmid><doi>10.1097/00004583-200108000-00013</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0890-8567 |
| ispartof | Journal of the American Academy of Child and Adolescent Psychiatry, 2001-08, Vol.40 (8), p.915-921 |
| issn | 0890-8567 1527-5418 |
| language | eng |
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| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; Access via ScienceDirect (Elsevier); Journals@Ovid Complete |
| subjects | Adolescent Analgesics Analgesics, Opioid - administration & dosage Anxiety disorders Biological and medical sciences Burns Burns - drug therapy Burns - psychology Child Child clinical studies Child psychology Dose-Response Relationship, Drug Female Follow-Up Studies Humans Male Medical sciences morphine Morphine - administration & dosage Narcotics Neuropharmacology Pain Measurement Pharmacology. Drug treatments Post traumatic stress disorder posttraumatic stress disorder Prevention Prospective Studies Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Research Design Sample Size Severity of Illness Index Stress Disorders, Post-Traumatic - etiology Stress Disorders, Post-Traumatic - prevention & control |
| title | Relationship Between Acute Morphine and the Course of PTSD in Children With Burns |
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