Novel transcripts encoding secreted forms of feline CD80 and CD86 costimulatory molecules
Engagement of costimulatory molecules such as CD28 or CD152 (CTLA4) on T cells by CD80 (B7-1) or CD86 (B7-2) dictates the nature of T cell-mediated immune responses. We previously reported the discovery of naturally occurring forms of canine CD80 and CD86 mRNAs which encode secreted CD80 and CD86 mo...
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| Veröffentlicht in: | Veterinary immunology and immunopathology 2001-08, Vol.81 (1), p.15-21 |
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| container_title | Veterinary immunology and immunopathology |
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| creator | Yang, Shumin Sellins, Karen S. Powell, Tim Stoneman, Earl Sim, Gek Kee |
| description | Engagement of costimulatory molecules such as CD28 or CD152 (CTLA4) on T cells by CD80 (B7-1) or CD86 (B7-2) dictates the nature of T cell-mediated immune responses. We previously reported the discovery of naturally occurring forms of canine CD80 and CD86 mRNAs which encode secreted CD80 and CD86 molecules. We report here that mRNAs for secreted forms of CD80 and CD86 are also expressed in cats. The mRNA for secreted feline CD86 is generated by deleting a transmembrane domain exon, which is the same mechanism we described for secreted canine CD86. We also identified a feline CD80 transcript that only retains the immunoglobulin variable-like domain. The detection of naturally occurring mRNAs encoding secreted CD80 and CD86 adds further complexity to the regulation of the B7-CD28/CD152 costimulatory pathway. |
| doi_str_mv | 10.1016/S0165-2427(01)00320-8 |
| format | Article |
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We previously reported the discovery of naturally occurring forms of canine CD80 and CD86 mRNAs which encode secreted CD80 and CD86 molecules. We report here that mRNAs for secreted forms of CD80 and CD86 are also expressed in cats. The mRNA for secreted feline CD86 is generated by deleting a transmembrane domain exon, which is the same mechanism we described for secreted canine CD86. We also identified a feline CD80 transcript that only retains the immunoglobulin variable-like domain. The detection of naturally occurring mRNAs encoding secreted CD80 and CD86 adds further complexity to the regulation of the B7-CD28/CD152 costimulatory pathway.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antigens, CD - chemistry</subject><subject>Antigens, CD - genetics</subject><subject>B7-1 Antigen - chemistry</subject><subject>B7-1 Antigen - genetics</subject><subject>B7-2 Antigen</subject><subject>Cats - immunology</subject><subject>CD80</subject><subject>CD80 antigen</subject><subject>CD86</subject><subject>CD86 antigen</subject><subject>Costimulatory molecules</subject><subject>Felis catus</subject><subject>Membrane Glycoproteins - chemistry</subject><subject>Membrane Glycoproteins - genetics</subject><subject>Molecular Sequence Data</subject><subject>RNA, Messenger - analysis</subject><subject>Soluble B7</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhq2qqCzb_oQinyo4BDx27DinCm3Lh7SCQ9tDT5bXGSOjJF7sZCX-fRN2RY9cZubwvO9IDyFfgV0AA3X5axqy4CWvzhicMyY4K_QHsgBdiYJLUX4kizfkmJzk_MQYk7XWn8gxQFlrXooF-Xsfd9jSIdk-uxS2Q6bYu9iE_pFmdAkHbKiPqcs0euqxDT3S1Q_NqO2b-VDUxTyEbmztENML7WKLbmwxfyZH3rYZvxz2kvy5_vl7dVusH27uVlfrwomaDwWIWjHOrZKbTc2kdVpKj4J7xS14ZZX1lmNtlbIlNBZcyaqqbirNVamFrMSSfNv3blN8HjEPpgvZYdvaHuOYTQVMCwHyXRD01CxgbpR70KWYc0Jvtil0Nr0YYGaWb17lm9msYWBe5Rs95U4PD8ZNh83_1MH2BHzfAzj52AVMJrsw6cYmJHSDaWJ458U_2oKSoQ</recordid><startdate>20010830</startdate><enddate>20010830</enddate><creator>Yang, Shumin</creator><creator>Sellins, Karen S.</creator><creator>Powell, Tim</creator><creator>Stoneman, Earl</creator><creator>Sim, Gek Kee</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20010830</creationdate><title>Novel transcripts encoding secreted forms of feline CD80 and CD86 costimulatory molecules</title><author>Yang, Shumin ; Sellins, Karen S. ; Powell, Tim ; Stoneman, Earl ; Sim, Gek Kee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-1396022a65bb905ac855fe32f62a1f6a6afa2e9a66a41da1c40779d7826483573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Antigens, CD - chemistry</topic><topic>Antigens, CD - genetics</topic><topic>B7-1 Antigen - chemistry</topic><topic>B7-1 Antigen - genetics</topic><topic>B7-2 Antigen</topic><topic>Cats - immunology</topic><topic>CD80</topic><topic>CD80 antigen</topic><topic>CD86</topic><topic>CD86 antigen</topic><topic>Costimulatory molecules</topic><topic>Felis catus</topic><topic>Membrane Glycoproteins - chemistry</topic><topic>Membrane Glycoproteins - genetics</topic><topic>Molecular Sequence Data</topic><topic>RNA, Messenger - analysis</topic><topic>Soluble B7</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Shumin</creatorcontrib><creatorcontrib>Sellins, Karen S.</creatorcontrib><creatorcontrib>Powell, Tim</creatorcontrib><creatorcontrib>Stoneman, Earl</creatorcontrib><creatorcontrib>Sim, Gek Kee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Shumin</au><au>Sellins, Karen S.</au><au>Powell, Tim</au><au>Stoneman, Earl</au><au>Sim, Gek Kee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel transcripts encoding secreted forms of feline CD80 and CD86 costimulatory molecules</atitle><jtitle>Veterinary immunology and immunopathology</jtitle><addtitle>Vet Immunol Immunopathol</addtitle><date>2001-08-30</date><risdate>2001</risdate><volume>81</volume><issue>1</issue><spage>15</spage><epage>21</epage><pages>15-21</pages><issn>0165-2427</issn><eissn>1873-2534</eissn><abstract>Engagement of costimulatory molecules such as CD28 or CD152 (CTLA4) on T cells by CD80 (B7-1) or CD86 (B7-2) dictates the nature of T cell-mediated immune responses. We previously reported the discovery of naturally occurring forms of canine CD80 and CD86 mRNAs which encode secreted CD80 and CD86 molecules. We report here that mRNAs for secreted forms of CD80 and CD86 are also expressed in cats. The mRNA for secreted feline CD86 is generated by deleting a transmembrane domain exon, which is the same mechanism we described for secreted canine CD86. We also identified a feline CD80 transcript that only retains the immunoglobulin variable-like domain. The detection of naturally occurring mRNAs encoding secreted CD80 and CD86 adds further complexity to the regulation of the B7-CD28/CD152 costimulatory pathway.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>11498243</pmid><doi>10.1016/S0165-2427(01)00320-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Veterinary immunology and immunopathology, 2001-08, Vol.81 (1), p.15-21 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acid Sequence Animals Antigens, CD - chemistry Antigens, CD - genetics B7-1 Antigen - chemistry B7-1 Antigen - genetics B7-2 Antigen Cats - immunology CD80 CD80 antigen CD86 CD86 antigen Costimulatory molecules Felis catus Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Molecular Sequence Data RNA, Messenger - analysis Soluble B7 |
| title | Novel transcripts encoding secreted forms of feline CD80 and CD86 costimulatory molecules |
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