Induction of apoptosis by mitomycin‐C in an ex vivo model of bladder cancer

Objective To examine mitomycin‐C (MMC)‐induced apoptosis in an ex vivo model of superficial TCC, and relate it to the in vivo response to chemotherapy. Materials and methods Dose‐ and time‐response curves were constructed to determine the optimal conditions for the induction of apoptosis by MMC in a...

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Veröffentlicht in:	BJU international 2000-05, Vol.85 (7), p.911-917
Hauptverfasser:	Kelly, J.D., Williamson, K.E., Weir, H.P., McManus, D.T., Hamilton, P.W., Keane, P.F., Johnston, S.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - therapeutic use Antineoplastic agents Apoptosis Biological and medical sciences bladder Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - pathology Carcinoma, Transitional Cell - physiopathology Chemotherapy Dose-Response Relationship, Drug Humans Medical sciences Mitomycin - therapeutic use Pharmacology. Drug treatments TCC Time Factors tissue culture Tumor Cells, Cultured Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - physiopathology
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