Arterial Elastase Activity After Balloon Angioplasty and Effects of Elafin, an Elastase Inhibitor

Increased proteolytic activity may be a factor in intimal hyperplasia after balloon angioplasty (BA). The objectives of this study were to assess elastase activity after BA in a rabbit arterial double-injury model and the effects of elastase inhibition. Elastase activity increased immediately after...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2001-08, Vol.21 (8), p.1269-1274
Hauptverfasser:	Barolet, Alan W, Nili, Nafiseh, Cheema, Asim, Robinson, Ranga, Natarajan, Madhu K, O’Blenes, Stacy, Li, Jing, Eskandarian, Mohammad R, Sparkes, John, Rabinovitch, Marlene, Strauss, Bradley H
Format:	Artikel
Sprache:	eng
Schlagworte:	Angioplasty, Balloon Animals Arteries - enzymology Arteries - pathology Arteriosclerosis - enzymology Arteriosclerosis - pathology Arteriosclerosis - therapy Biological and medical sciences Carotid Arteries Diseases of the cardiovascular system DNA, Complementary Electrophoresis, Polyacrylamide Gel Hyperplasia Iliac Artery Immunohistochemistry Liposomes Medical sciences Models, Animal Muscle, Smooth, Vascular - enzymology Pancreatic Elastase - antagonists & inhibitors Pancreatic Elastase - metabolism Plasmids Proteinase Inhibitory Proteins, Secretory Proteins - genetics Proteins - pharmacology Rabbits Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Respirovirus Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - analysis Serine Proteinase Inhibitors - pharmacology Transfection Transgenes Tunica Intima - enzymology Tunica Intima - pathology
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