The alpha(2A) adrenoceptor and the sympathetic postganglionic neuron contribute to the development of neuropathic heat hyperalgesia in mice

We have addressed the role of the sympathetic nervous system in the development and maintenance of neuropathic pain. Using a new neuropathic mouse model, we examined the development of hyperalgesia in transgenic mice lacking functional alpha(2A) adrenoceptors and in sympathectomized wild-type mice,...

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Veröffentlicht in:	Pain (Amsterdam) 2000-04, Vol.85 (3), p.345-358
Hauptverfasser:	Kingery, Wade S, Guo, Tian Z, Davies, Frances M, Limbird, Lee, Maze, Mervyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists - pharmacology Adrenergic alpha-Antagonists - pharmacology Analgesics, Non-Narcotic - pharmacology Anesthetics, Inhalation - pharmacology Animals Brain Chemistry - drug effects Dexmedetomidine - pharmacology Hot Temperature Hyperalgesia - metabolism Hyperalgesia - physiopathology Isoflurane - pharmacology Mice Mice, Inbred Strains Neurons - metabolism Neurons - physiology Nociceptors - physiology Pain Measurement Peripheral Nerve Injuries Peripheral Nerves - metabolism Physical Stimulation Receptors, Adrenergic, alpha-2 - metabolism Receptors, Adrenergic, alpha-2 - physiology Sympathectomy Sympathetic Fibers, Postganglionic - metabolism Sympathetic Fibers, Postganglionic - physiology Tibial Nerve - injuries Tibial Nerve - metabolism
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