Nerve growth factor stimulates the interaction of ZIP/p62 with atypical protein kinase C and targets endosomal localization: Evidence for regulation of nerve growth factor-induced differentiation

Atypical protein kinase Cs zeta and lambda/iota play a functional role in the regulation of NGF‐induced differentiation and survival of pheochromocytoma, PC12 cells [Coleman and Wooten, 1994; Wooten et al., 1999]. Here we demonstrate an NGF‐dependent interaction of aPKC with its binding protein, ZIP...

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Veröffentlicht in:	Journal of cellular biochemistry 2001-01, Vol.82 (3), p.452-466
Hauptverfasser:	Samuels, Ivy S., Seibenhener, M. Lamar, Neidigh, Kimberly B.W., Wooten, Marie W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals atypical protein kinase C Blotting, Western Carrier Proteins - metabolism Cell Differentiation - drug effects Cell Line Cell Size - drug effects Endosomes - drug effects Endosomes - metabolism Humans Isoenzymes - metabolism Microscopy, Fluorescence nerve growth factor Nerve Growth Factor - pharmacology Neurites - drug effects Neurites - enzymology Neurites - metabolism neurotrophin PC12 PC12 Cells Phosphorylation Phosphotyrosine - metabolism Precipitin Tests Protein Binding - drug effects Protein Kinase C - metabolism Protein Transport - drug effects Protein-Tyrosine Kinases - metabolism Rats scaffold src-Family Kinases Structure-Activity Relationship Substrate Specificity tyrosine phosphorylation
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